Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome

Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immu...

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Veröffentlicht in:	Blood 2010-11, Vol.116 (22), p.4523-4531
Hauptverfasser:	Terrier, Benjamin, Bièche, Ivan, Maisonobe, Thierry, Laurendeau, Ingrid, Rosenzwajg, Michèlle, Kahn, Jean-Emmanuel, Diemert, Marie-Claude, Musset, Lucile, Vidaud, Michel, Sène, Damien, Costedoat-Chalumeau, Nathalie, Le Thi-Huong, Du, Amoura, Zahir, Klatzmann, David, Cacoub, Patrice, Saadoun, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Adolescent Adult Aged Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Churg-Strauss Syndrome - genetics Churg-Strauss Syndrome - immunology Churg-Strauss Syndrome - pathology Eosinophils - immunology Female Gene Expression Profiling Hematologic and hematopoietic diseases Humans Interleukin-17 - blood Interleukin-17 - genetics Interleukin-17 - immunology Male Medical sciences Middle Aged Receptors, Interleukin - genetics Receptors, Interleukin - immunology Receptors, Interleukin-17 Vasculitis - genetics Vasculitis - immunology Vasculitis - pathology Young Adult
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