Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome
Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immu...
Gespeichert in:
| Veröffentlicht in: | Blood 2010-11, Vol.116 (22), p.4523-4531 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4531 |
|---|---|
| container_issue | 22 |
| container_start_page | 4523 |
| container_title | Blood |
| container_volume | 116 |
| creator | Terrier, Benjamin Bièche, Ivan Maisonobe, Thierry Laurendeau, Ingrid Rosenzwajg, Michèlle Kahn, Jean-Emmanuel Diemert, Marie-Claude Musset, Lucile Vidaud, Michel Sène, Damien Costedoat-Chalumeau, Nathalie Le Thi-Huong, Du Amoura, Zahir Klatzmann, David Cacoub, Patrice Saadoun, David |
| description | Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immunity by enhancing Th2 cytokine production. We sought to determine the involvement of IL-25 and its receptor IL-17RB in the pathogenesis of CSS. We found increased levels of IL-25 in the serum of active CSS patients (952 ± 697 vs 75 ± 49 pg/mL in inactive patients and 47 ± 6 pg/mL in healthy donors). IL-25 was correlated with disease activity and eosinophil level. Eosinophils were the main source of IL-25, whereas activated CD4+ memory T cells were the IL-17RB–expressing cells in CSS. IL-25 enhanced the production of IL-4, IL-5, and IL-13 by activated peripheral blood mononuclear cells. IL-25 and IL-17RB were observed within the vasculitic lesions of patients with CSS, and IL-17RB colocalized with T cells. Increased expression of IL-17RB, tumor necrosis factor receptor–associated factor 6, and JunB in vasculitic lesions of CSS underscored the IL-25–mediated activation, whereas up-regulation of GATA3 and IL-10 supported Th2 differentiation. Our findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of CSS. |
| doi_str_mv | 10.1182/blood-2010-02-267542 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_814466030</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006497120310077</els_id><sourcerecordid>814466030</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-659cd005e942a7b2140116f9928ac9e350ec384e65b41759c71407dc3dd8de2b3</originalsourceid><addsrcrecordid>eNp90M9rFDEUwPEgit1W_wORXMRT9OXnzHgQZNFaKHhQr4ZM8raNziRrMlPY_97UXfXm6RH4vCR8CXnG4RXnvXg9TjkHJoADA8GE6bQSD8iGa9EzAAEPyQYADFNDx8_Iea3fAbiSQj8mZwI6MSjTb8i3q7RgmXD9ERMT-g111B-W3E5Ip5javKGYa0x5fxunSl0K1AW3X-Id0jjPa4rLgcZEt7druWGfl-LWWmk9pFDyjE_Io52bKj49zQvy9cP7L9uP7PrT5dX23TXzGuTCjB58ANA4KOG6UXAFnJvdMIje-QGlBvSyV2j0qHjXcNdEF7wMoQ8oRnlBXh7v3Zf8c8W62DlWj9PkEua12p4rZQxIaFIdpS-51oI7uy9xduVgOdj7sPZ3WHsf1oKwx7Bt7fnpgXWcMfxd-lOygRcn4Kp306645GP956QyUvVdc2-PDluOu4jFVh8xeQyxoF9syPH_P_kFj-eW5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>814466030</pqid></control><display><type>article</type><title>Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Terrier, Benjamin ; Bièche, Ivan ; Maisonobe, Thierry ; Laurendeau, Ingrid ; Rosenzwajg, Michèlle ; Kahn, Jean-Emmanuel ; Diemert, Marie-Claude ; Musset, Lucile ; Vidaud, Michel ; Sène, Damien ; Costedoat-Chalumeau, Nathalie ; Le Thi-Huong, Du ; Amoura, Zahir ; Klatzmann, David ; Cacoub, Patrice ; Saadoun, David</creator><creatorcontrib>Terrier, Benjamin ; Bièche, Ivan ; Maisonobe, Thierry ; Laurendeau, Ingrid ; Rosenzwajg, Michèlle ; Kahn, Jean-Emmanuel ; Diemert, Marie-Claude ; Musset, Lucile ; Vidaud, Michel ; Sène, Damien ; Costedoat-Chalumeau, Nathalie ; Le Thi-Huong, Du ; Amoura, Zahir ; Klatzmann, David ; Cacoub, Patrice ; Saadoun, David</creatorcontrib><description>Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immunity by enhancing Th2 cytokine production. We sought to determine the involvement of IL-25 and its receptor IL-17RB in the pathogenesis of CSS. We found increased levels of IL-25 in the serum of active CSS patients (952 ± 697 vs 75 ± 49 pg/mL in inactive patients and 47 ± 6 pg/mL in healthy donors). IL-25 was correlated with disease activity and eosinophil level. Eosinophils were the main source of IL-25, whereas activated CD4+ memory T cells were the IL-17RB–expressing cells in CSS. IL-25 enhanced the production of IL-4, IL-5, and IL-13 by activated peripheral blood mononuclear cells. IL-25 and IL-17RB were observed within the vasculitic lesions of patients with CSS, and IL-17RB colocalized with T cells. Increased expression of IL-17RB, tumor necrosis factor receptor–associated factor 6, and JunB in vasculitic lesions of CSS underscored the IL-25–mediated activation, whereas up-regulation of GATA3 and IL-10 supported Th2 differentiation. Our findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of CSS.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2010-02-267542</identifier><identifier>PMID: 20729468</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adaptive Immunity ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Churg-Strauss Syndrome - genetics ; Churg-Strauss Syndrome - immunology ; Churg-Strauss Syndrome - pathology ; Eosinophils - immunology ; Female ; Gene Expression Profiling ; Hematologic and hematopoietic diseases ; Humans ; Interleukin-17 - blood ; Interleukin-17 - genetics ; Interleukin-17 - immunology ; Male ; Medical sciences ; Middle Aged ; Receptors, Interleukin - genetics ; Receptors, Interleukin - immunology ; Receptors, Interleukin-17 ; Vasculitis - genetics ; Vasculitis - immunology ; Vasculitis - pathology ; Young Adult</subject><ispartof>Blood, 2010-11, Vol.116 (22), p.4523-4531</ispartof><rights>2010 American Society of Hematology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-659cd005e942a7b2140116f9928ac9e350ec384e65b41759c71407dc3dd8de2b3</citedby><cites>FETCH-LOGICAL-c503t-659cd005e942a7b2140116f9928ac9e350ec384e65b41759c71407dc3dd8de2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23463487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20729468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terrier, Benjamin</creatorcontrib><creatorcontrib>Bièche, Ivan</creatorcontrib><creatorcontrib>Maisonobe, Thierry</creatorcontrib><creatorcontrib>Laurendeau, Ingrid</creatorcontrib><creatorcontrib>Rosenzwajg, Michèlle</creatorcontrib><creatorcontrib>Kahn, Jean-Emmanuel</creatorcontrib><creatorcontrib>Diemert, Marie-Claude</creatorcontrib><creatorcontrib>Musset, Lucile</creatorcontrib><creatorcontrib>Vidaud, Michel</creatorcontrib><creatorcontrib>Sène, Damien</creatorcontrib><creatorcontrib>Costedoat-Chalumeau, Nathalie</creatorcontrib><creatorcontrib>Le Thi-Huong, Du</creatorcontrib><creatorcontrib>Amoura, Zahir</creatorcontrib><creatorcontrib>Klatzmann, David</creatorcontrib><creatorcontrib>Cacoub, Patrice</creatorcontrib><creatorcontrib>Saadoun, David</creatorcontrib><title>Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome</title><title>Blood</title><addtitle>Blood</addtitle><description>Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immunity by enhancing Th2 cytokine production. We sought to determine the involvement of IL-25 and its receptor IL-17RB in the pathogenesis of CSS. We found increased levels of IL-25 in the serum of active CSS patients (952 ± 697 vs 75 ± 49 pg/mL in inactive patients and 47 ± 6 pg/mL in healthy donors). IL-25 was correlated with disease activity and eosinophil level. Eosinophils were the main source of IL-25, whereas activated CD4+ memory T cells were the IL-17RB–expressing cells in CSS. IL-25 enhanced the production of IL-4, IL-5, and IL-13 by activated peripheral blood mononuclear cells. IL-25 and IL-17RB were observed within the vasculitic lesions of patients with CSS, and IL-17RB colocalized with T cells. Increased expression of IL-17RB, tumor necrosis factor receptor–associated factor 6, and JunB in vasculitic lesions of CSS underscored the IL-25–mediated activation, whereas up-regulation of GATA3 and IL-10 supported Th2 differentiation. Our findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of CSS.</description><subject>Adaptive Immunity</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Churg-Strauss Syndrome - genetics</subject><subject>Churg-Strauss Syndrome - immunology</subject><subject>Churg-Strauss Syndrome - pathology</subject><subject>Eosinophils - immunology</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Interleukin-17 - blood</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-17 - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, Interleukin - genetics</subject><subject>Receptors, Interleukin - immunology</subject><subject>Receptors, Interleukin-17</subject><subject>Vasculitis - genetics</subject><subject>Vasculitis - immunology</subject><subject>Vasculitis - pathology</subject><subject>Young Adult</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M9rFDEUwPEgit1W_wORXMRT9OXnzHgQZNFaKHhQr4ZM8raNziRrMlPY_97UXfXm6RH4vCR8CXnG4RXnvXg9TjkHJoADA8GE6bQSD8iGa9EzAAEPyQYADFNDx8_Iea3fAbiSQj8mZwI6MSjTb8i3q7RgmXD9ERMT-g111B-W3E5Ip5javKGYa0x5fxunSl0K1AW3X-Id0jjPa4rLgcZEt7druWGfl-LWWmk9pFDyjE_Io52bKj49zQvy9cP7L9uP7PrT5dX23TXzGuTCjB58ANA4KOG6UXAFnJvdMIje-QGlBvSyV2j0qHjXcNdEF7wMoQ8oRnlBXh7v3Zf8c8W62DlWj9PkEua12p4rZQxIaFIdpS-51oI7uy9xduVgOdj7sPZ3WHsf1oKwx7Bt7fnpgXWcMfxd-lOygRcn4Kp306645GP956QyUvVdc2-PDluOu4jFVh8xeQyxoF9syPH_P_kFj-eW5Q</recordid><startdate>20101125</startdate><enddate>20101125</enddate><creator>Terrier, Benjamin</creator><creator>Bièche, Ivan</creator><creator>Maisonobe, Thierry</creator><creator>Laurendeau, Ingrid</creator><creator>Rosenzwajg, Michèlle</creator><creator>Kahn, Jean-Emmanuel</creator><creator>Diemert, Marie-Claude</creator><creator>Musset, Lucile</creator><creator>Vidaud, Michel</creator><creator>Sène, Damien</creator><creator>Costedoat-Chalumeau, Nathalie</creator><creator>Le Thi-Huong, Du</creator><creator>Amoura, Zahir</creator><creator>Klatzmann, David</creator><creator>Cacoub, Patrice</creator><creator>Saadoun, David</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101125</creationdate><title>Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome</title><author>Terrier, Benjamin ; Bièche, Ivan ; Maisonobe, Thierry ; Laurendeau, Ingrid ; Rosenzwajg, Michèlle ; Kahn, Jean-Emmanuel ; Diemert, Marie-Claude ; Musset, Lucile ; Vidaud, Michel ; Sène, Damien ; Costedoat-Chalumeau, Nathalie ; Le Thi-Huong, Du ; Amoura, Zahir ; Klatzmann, David ; Cacoub, Patrice ; Saadoun, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-659cd005e942a7b2140116f9928ac9e350ec384e65b41759c71407dc3dd8de2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adaptive Immunity</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Churg-Strauss Syndrome - genetics</topic><topic>Churg-Strauss Syndrome - immunology</topic><topic>Churg-Strauss Syndrome - pathology</topic><topic>Eosinophils - immunology</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Interleukin-17 - blood</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-17 - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Interleukin - genetics</topic><topic>Receptors, Interleukin - immunology</topic><topic>Receptors, Interleukin-17</topic><topic>Vasculitis - genetics</topic><topic>Vasculitis - immunology</topic><topic>Vasculitis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terrier, Benjamin</creatorcontrib><creatorcontrib>Bièche, Ivan</creatorcontrib><creatorcontrib>Maisonobe, Thierry</creatorcontrib><creatorcontrib>Laurendeau, Ingrid</creatorcontrib><creatorcontrib>Rosenzwajg, Michèlle</creatorcontrib><creatorcontrib>Kahn, Jean-Emmanuel</creatorcontrib><creatorcontrib>Diemert, Marie-Claude</creatorcontrib><creatorcontrib>Musset, Lucile</creatorcontrib><creatorcontrib>Vidaud, Michel</creatorcontrib><creatorcontrib>Sène, Damien</creatorcontrib><creatorcontrib>Costedoat-Chalumeau, Nathalie</creatorcontrib><creatorcontrib>Le Thi-Huong, Du</creatorcontrib><creatorcontrib>Amoura, Zahir</creatorcontrib><creatorcontrib>Klatzmann, David</creatorcontrib><creatorcontrib>Cacoub, Patrice</creatorcontrib><creatorcontrib>Saadoun, David</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terrier, Benjamin</au><au>Bièche, Ivan</au><au>Maisonobe, Thierry</au><au>Laurendeau, Ingrid</au><au>Rosenzwajg, Michèlle</au><au>Kahn, Jean-Emmanuel</au><au>Diemert, Marie-Claude</au><au>Musset, Lucile</au><au>Vidaud, Michel</au><au>Sène, Damien</au><au>Costedoat-Chalumeau, Nathalie</au><au>Le Thi-Huong, Du</au><au>Amoura, Zahir</au><au>Klatzmann, David</au><au>Cacoub, Patrice</au><au>Saadoun, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2010-11-25</date><risdate>2010</risdate><volume>116</volume><issue>22</issue><spage>4523</spage><epage>4531</epage><pages>4523-4531</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Churg-Strauss syndrome (CSS) is characterized by systemic vasculitis and blood and tissue eosinophilia. Blood eosinophilia correlates with disease activity, and activated T cells from CSS patients are predominantly T helper 2 (Th2). Interleukin (IL)-25 has been shown to link innate and adaptive immunity by enhancing Th2 cytokine production. We sought to determine the involvement of IL-25 and its receptor IL-17RB in the pathogenesis of CSS. We found increased levels of IL-25 in the serum of active CSS patients (952 ± 697 vs 75 ± 49 pg/mL in inactive patients and 47 ± 6 pg/mL in healthy donors). IL-25 was correlated with disease activity and eosinophil level. Eosinophils were the main source of IL-25, whereas activated CD4+ memory T cells were the IL-17RB–expressing cells in CSS. IL-25 enhanced the production of IL-4, IL-5, and IL-13 by activated peripheral blood mononuclear cells. IL-25 and IL-17RB were observed within the vasculitic lesions of patients with CSS, and IL-17RB colocalized with T cells. Increased expression of IL-17RB, tumor necrosis factor receptor–associated factor 6, and JunB in vasculitic lesions of CSS underscored the IL-25–mediated activation, whereas up-regulation of GATA3 and IL-10 supported Th2 differentiation. Our findings suggest that eosinophils, through the production of IL-25, exert a critical role in promoting Th2 responses in target tissues of CSS.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>20729468</pmid><doi>10.1182/blood-2010-02-267542</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2010-11, Vol.116 (22), p.4523-4531 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_814466030 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adaptive Immunity Adolescent Adult Aged Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Churg-Strauss Syndrome - genetics Churg-Strauss Syndrome - immunology Churg-Strauss Syndrome - pathology Eosinophils - immunology Female Gene Expression Profiling Hematologic and hematopoietic diseases Humans Interleukin-17 - blood Interleukin-17 - genetics Interleukin-17 - immunology Male Medical sciences Middle Aged Receptors, Interleukin - genetics Receptors, Interleukin - immunology Receptors, Interleukin-17 Vasculitis - genetics Vasculitis - immunology Vasculitis - pathology Young Adult |
| title | Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A24%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-25:%20a%20cytokine%20linking%20eosinophils%20and%20adaptive%20immunity%20in%20Churg-Strauss%20syndrome&rft.jtitle=Blood&rft.au=Terrier,%20Benjamin&rft.date=2010-11-25&rft.volume=116&rft.issue=22&rft.spage=4523&rft.epage=4531&rft.pages=4523-4531&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2010-02-267542&rft_dat=%3Cproquest_cross%3E814466030%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=814466030&rft_id=info:pmid/20729468&rft_els_id=S0006497120310077&rfr_iscdi=true |