c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define its role during the hematopoietic lineage commitment, we silenced c-myb in human CD34+ hematopoietic stem/progenitor cells. Noteworthy, c-myb silencing increased th...

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Veröffentlicht in:	Blood 2010-11, Vol.116 (22), p.e99-e110
Hauptverfasser:	Bianchi, Elisa, Zini, Roberta, Salati, Simona, Tenedini, Elena, Norfo, Ruggiero, Tagliafico, Enrico, Manfredini, Rossella, Ferrari, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Antigens, CD34 - metabolism Cells, Cultured DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Erythropoiesis Gene Expression Regulation Gene Silencing Granulocyte Precursor Cells - cytology Granulocyte Precursor Cells - metabolism Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism LIM Domain Proteins Metalloproteins - genetics Metalloproteins - metabolism Proto-Oncogene Proteins Proto-Oncogene Proteins c-myb - genetics Proto-Oncogene Proteins c-myb - metabolism Stem Cells - cytology Stem Cells - metabolism
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