Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks
The last trimester of the embryonic life of chickens is marked by a steady increase in circulating thyroxine (T 4) levels, reaching a maximum around hatching. We have measured thyroidal mRNA expression levels of several genes involved in the biosynthesis of T 4, namely sodium/iodine symporter ( NIS)...
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| Veröffentlicht in: | Domestic animal endocrinology 2011, Vol.40 (1), p.10-18 |
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| creator | Grommen, S.V.H. Iwasawa, A. Beck, V. Darras, V.M. De Groef, B. |
| description | The last trimester of the embryonic life of chickens is marked by a steady increase in circulating thyroxine (T
4) levels, reaching a maximum around hatching. We have measured thyroidal mRNA expression levels of several genes involved in the biosynthesis of T
4, namely sodium/iodine symporter (
NIS), thyroglobulin (
Tg), thyroid peroxidase (
TPO), thyrotropin receptor (
TSHR), and thyroid transcription factor 1 (
TTF-1), during this period. Subsequently, we measured the expression of these genes in more detail during the entire hatching process and compared the gene expression profiles with concomitant changes in intrathyroidal and circulating thyroid hormone levels. We found that NIS and TPO mRNA expression increased significantly in the perinatal period, whereas Tg mRNA expression rose gradually throughout the last week of embryogenesis but was stable during hatching. TSHR and TTF-1 mRNA levels did not change significantly during the last week of embryonic development and hatching. Our results suggest that the elevated plasma T
4 levels observed in the developmental period studied are caused by an increased synthesis and secretion of T
4 by the thyroid gland. Augmented expression of Tg may play an important role in the increasing T
4 production during the last week of embryonic development, whereas increased NIS and TPO expression around hatching allows the thyrocytes to boost T
4 synthesis even further. |
| doi_str_mv | 10.1016/j.domaniend.2010.08.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_814465492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0739724010000834</els_id><sourcerecordid>814465492</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-dcee322e105708fd1152d7388128779c7d7019d6b5b86d9fcd3d81891e0c6bde3</originalsourceid><addsrcrecordid>eNqFkE1PGzEQhi3UClLgL8Deetp07P2wfUQIChISB0Dqzdq1ZxOHrB3sDSL_vhOFcu3FluznnXn1MHbJYc6Bt79WcxfHLngMbi6AXkHNAcQRm3EldQnQ1N_YDGSlSylqOGE_cl4BgKT0MTsRoEUrhJyxP49higsM3hb4sUmYs4-h2KQ4-DXmIg7FtNyl6F2ZN2j9QBzR9ONDgWOfdnEf7YIrlt1klz4sCjrtaz5j34dunfH88z5lL7c3z9d35cPj7_vrq4fSVrqeSmcRKyGQQyNBDY7zRjhZKcWFklJb6SRw7dq-6VXr9GBd5RRXmiPYtndYnbKfh7nU-W2LeTKjzxbX6y5g3GajeF23Ta0FkfJA2hRzTjiYTfJjl3aGg9lbNSvzZdXsrRpQhqxS8uJzx7Yf0X3l_mkk4PIADF003SL5bF6eaEJF3XkrBRBxdSCQXLx7TCZb2mPR-YR2osX-vzX-AuIElvo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>814465492</pqid></control><display><type>article</type><title>Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Grommen, S.V.H. ; Iwasawa, A. ; Beck, V. ; Darras, V.M. ; De Groef, B.</creator><creatorcontrib>Grommen, S.V.H. ; Iwasawa, A. ; Beck, V. ; Darras, V.M. ; De Groef, B.</creatorcontrib><description>The last trimester of the embryonic life of chickens is marked by a steady increase in circulating thyroxine (T
4) levels, reaching a maximum around hatching. We have measured thyroidal mRNA expression levels of several genes involved in the biosynthesis of T
4, namely sodium/iodine symporter (
NIS), thyroglobulin (
Tg), thyroid peroxidase (
TPO), thyrotropin receptor (
TSHR), and thyroid transcription factor 1 (
TTF-1), during this period. Subsequently, we measured the expression of these genes in more detail during the entire hatching process and compared the gene expression profiles with concomitant changes in intrathyroidal and circulating thyroid hormone levels. We found that NIS and TPO mRNA expression increased significantly in the perinatal period, whereas Tg mRNA expression rose gradually throughout the last week of embryogenesis but was stable during hatching. TSHR and TTF-1 mRNA levels did not change significantly during the last week of embryonic development and hatching. Our results suggest that the elevated plasma T
4 levels observed in the developmental period studied are caused by an increased synthesis and secretion of T
4 by the thyroid gland. Augmented expression of Tg may play an important role in the increasing T
4 production during the last week of embryonic development, whereas increased NIS and TPO expression around hatching allows the thyrocytes to boost T
4 synthesis even further.</description><identifier>ISSN: 0739-7240</identifier><identifier>EISSN: 1879-0054</identifier><identifier>DOI: 10.1016/j.domaniend.2010.08.002</identifier><identifier>PMID: 20926227</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; biosynthesis ; Chick Embryo - growth & development ; Chick Embryo - metabolism ; Chicken ; chickens ; Chickens - metabolism ; chicks ; Development ; embryo (animal) ; embryogenesis ; Gene expression ; Gene Expression Profiling - veterinary ; gene expression regulation ; hatching ; hormonal regulation ; hormone receptors ; iodide peroxidase ; Iodide Peroxidase - genetics ; L-thyroxine ; messenger RNA ; Nuclear Proteins - genetics ; ontogeny ; perinatal period ; Receptors, Thyrotropin - genetics ; RNA, Messenger - analysis ; sodium/iodine symporter ; symporters ; Symporters - genetics ; temporal variation ; thyroglobulin ; Thyroglobulin - genetics ; Thyroid gland ; Thyroid Gland - embryology ; Thyroid Gland - metabolism ; Thyroid hormones ; Thyroid Nuclear Factor 1 ; thyroid transcription factor 1 ; thyrotropin ; thyrotropin receptor ; Thyroxine - biosynthesis ; Thyroxine - genetics ; Time Factors ; transcription factors ; Transcription Factors - genetics</subject><ispartof>Domestic animal endocrinology, 2011, Vol.40 (1), p.10-18</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-dcee322e105708fd1152d7388128779c7d7019d6b5b86d9fcd3d81891e0c6bde3</citedby><cites>FETCH-LOGICAL-c394t-dcee322e105708fd1152d7388128779c7d7019d6b5b86d9fcd3d81891e0c6bde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.domaniend.2010.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20926227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grommen, S.V.H.</creatorcontrib><creatorcontrib>Iwasawa, A.</creatorcontrib><creatorcontrib>Beck, V.</creatorcontrib><creatorcontrib>Darras, V.M.</creatorcontrib><creatorcontrib>De Groef, B.</creatorcontrib><title>Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks</title><title>Domestic animal endocrinology</title><addtitle>Domest Anim Endocrinol</addtitle><description>The last trimester of the embryonic life of chickens is marked by a steady increase in circulating thyroxine (T
4) levels, reaching a maximum around hatching. We have measured thyroidal mRNA expression levels of several genes involved in the biosynthesis of T
4, namely sodium/iodine symporter (
NIS), thyroglobulin (
Tg), thyroid peroxidase (
TPO), thyrotropin receptor (
TSHR), and thyroid transcription factor 1 (
TTF-1), during this period. Subsequently, we measured the expression of these genes in more detail during the entire hatching process and compared the gene expression profiles with concomitant changes in intrathyroidal and circulating thyroid hormone levels. We found that NIS and TPO mRNA expression increased significantly in the perinatal period, whereas Tg mRNA expression rose gradually throughout the last week of embryogenesis but was stable during hatching. TSHR and TTF-1 mRNA levels did not change significantly during the last week of embryonic development and hatching. Our results suggest that the elevated plasma T
4 levels observed in the developmental period studied are caused by an increased synthesis and secretion of T
4 by the thyroid gland. Augmented expression of Tg may play an important role in the increasing T
4 production during the last week of embryonic development, whereas increased NIS and TPO expression around hatching allows the thyrocytes to boost T
4 synthesis even further.</description><subject>Animals</subject><subject>biosynthesis</subject><subject>Chick Embryo - growth & development</subject><subject>Chick Embryo - metabolism</subject><subject>Chicken</subject><subject>chickens</subject><subject>Chickens - metabolism</subject><subject>chicks</subject><subject>Development</subject><subject>embryo (animal)</subject><subject>embryogenesis</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - veterinary</subject><subject>gene expression regulation</subject><subject>hatching</subject><subject>hormonal regulation</subject><subject>hormone receptors</subject><subject>iodide peroxidase</subject><subject>Iodide Peroxidase - genetics</subject><subject>L-thyroxine</subject><subject>messenger RNA</subject><subject>Nuclear Proteins - genetics</subject><subject>ontogeny</subject><subject>perinatal period</subject><subject>Receptors, Thyrotropin - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>sodium/iodine symporter</subject><subject>symporters</subject><subject>Symporters - genetics</subject><subject>temporal variation</subject><subject>thyroglobulin</subject><subject>Thyroglobulin - genetics</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - embryology</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid hormones</subject><subject>Thyroid Nuclear Factor 1</subject><subject>thyroid transcription factor 1</subject><subject>thyrotropin</subject><subject>thyrotropin receptor</subject><subject>Thyroxine - biosynthesis</subject><subject>Thyroxine - genetics</subject><subject>Time Factors</subject><subject>transcription factors</subject><subject>Transcription Factors - genetics</subject><issn>0739-7240</issn><issn>1879-0054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhi3UClLgL8Deetp07P2wfUQIChISB0Dqzdq1ZxOHrB3sDSL_vhOFcu3FluznnXn1MHbJYc6Bt79WcxfHLngMbi6AXkHNAcQRm3EldQnQ1N_YDGSlSylqOGE_cl4BgKT0MTsRoEUrhJyxP49higsM3hb4sUmYs4-h2KQ4-DXmIg7FtNyl6F2ZN2j9QBzR9ONDgWOfdnEf7YIrlt1klz4sCjrtaz5j34dunfH88z5lL7c3z9d35cPj7_vrq4fSVrqeSmcRKyGQQyNBDY7zRjhZKcWFklJb6SRw7dq-6VXr9GBd5RRXmiPYtndYnbKfh7nU-W2LeTKjzxbX6y5g3GajeF23Ta0FkfJA2hRzTjiYTfJjl3aGg9lbNSvzZdXsrRpQhqxS8uJzx7Yf0X3l_mkk4PIADF003SL5bF6eaEJF3XkrBRBxdSCQXLx7TCZb2mPR-YR2osX-vzX-AuIElvo</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Grommen, S.V.H.</creator><creator>Iwasawa, A.</creator><creator>Beck, V.</creator><creator>Darras, V.M.</creator><creator>De Groef, B.</creator><general>Elsevier Inc</general><general>[Amsterdam; New York]: Elsevier Science Pub. Co</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks</title><author>Grommen, S.V.H. ; Iwasawa, A. ; Beck, V. ; Darras, V.M. ; De Groef, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-dcee322e105708fd1152d7388128779c7d7019d6b5b86d9fcd3d81891e0c6bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>biosynthesis</topic><topic>Chick Embryo - growth & development</topic><topic>Chick Embryo - metabolism</topic><topic>Chicken</topic><topic>chickens</topic><topic>Chickens - metabolism</topic><topic>chicks</topic><topic>Development</topic><topic>embryo (animal)</topic><topic>embryogenesis</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - veterinary</topic><topic>gene expression regulation</topic><topic>hatching</topic><topic>hormonal regulation</topic><topic>hormone receptors</topic><topic>iodide peroxidase</topic><topic>Iodide Peroxidase - genetics</topic><topic>L-thyroxine</topic><topic>messenger RNA</topic><topic>Nuclear Proteins - genetics</topic><topic>ontogeny</topic><topic>perinatal period</topic><topic>Receptors, Thyrotropin - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>sodium/iodine symporter</topic><topic>symporters</topic><topic>Symporters - genetics</topic><topic>temporal variation</topic><topic>thyroglobulin</topic><topic>Thyroglobulin - genetics</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - embryology</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid hormones</topic><topic>Thyroid Nuclear Factor 1</topic><topic>thyroid transcription factor 1</topic><topic>thyrotropin</topic><topic>thyrotropin receptor</topic><topic>Thyroxine - biosynthesis</topic><topic>Thyroxine - genetics</topic><topic>Time Factors</topic><topic>transcription factors</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grommen, S.V.H.</creatorcontrib><creatorcontrib>Iwasawa, A.</creatorcontrib><creatorcontrib>Beck, V.</creatorcontrib><creatorcontrib>Darras, V.M.</creatorcontrib><creatorcontrib>De Groef, B.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Domestic animal endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grommen, S.V.H.</au><au>Iwasawa, A.</au><au>Beck, V.</au><au>Darras, V.M.</au><au>De Groef, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks</atitle><jtitle>Domestic animal endocrinology</jtitle><addtitle>Domest Anim Endocrinol</addtitle><date>2011</date><risdate>2011</risdate><volume>40</volume><issue>1</issue><spage>10</spage><epage>18</epage><pages>10-18</pages><issn>0739-7240</issn><eissn>1879-0054</eissn><abstract>The last trimester of the embryonic life of chickens is marked by a steady increase in circulating thyroxine (T
4) levels, reaching a maximum around hatching. We have measured thyroidal mRNA expression levels of several genes involved in the biosynthesis of T
4, namely sodium/iodine symporter (
NIS), thyroglobulin (
Tg), thyroid peroxidase (
TPO), thyrotropin receptor (
TSHR), and thyroid transcription factor 1 (
TTF-1), during this period. Subsequently, we measured the expression of these genes in more detail during the entire hatching process and compared the gene expression profiles with concomitant changes in intrathyroidal and circulating thyroid hormone levels. We found that NIS and TPO mRNA expression increased significantly in the perinatal period, whereas Tg mRNA expression rose gradually throughout the last week of embryogenesis but was stable during hatching. TSHR and TTF-1 mRNA levels did not change significantly during the last week of embryonic development and hatching. Our results suggest that the elevated plasma T
4 levels observed in the developmental period studied are caused by an increased synthesis and secretion of T
4 by the thyroid gland. Augmented expression of Tg may play an important role in the increasing T
4 production during the last week of embryonic development, whereas increased NIS and TPO expression around hatching allows the thyrocytes to boost T
4 synthesis even further.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20926227</pmid><doi>10.1016/j.domaniend.2010.08.002</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0739-7240 |
| ispartof | Domestic animal endocrinology, 2011, Vol.40 (1), p.10-18 |
| issn | 0739-7240 1879-0054 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals biosynthesis Chick Embryo - growth & development Chick Embryo - metabolism Chicken chickens Chickens - metabolism chicks Development embryo (animal) embryogenesis Gene expression Gene Expression Profiling - veterinary gene expression regulation hatching hormonal regulation hormone receptors iodide peroxidase Iodide Peroxidase - genetics L-thyroxine messenger RNA Nuclear Proteins - genetics ontogeny perinatal period Receptors, Thyrotropin - genetics RNA, Messenger - analysis sodium/iodine symporter symporters Symporters - genetics temporal variation thyroglobulin Thyroglobulin - genetics Thyroid gland Thyroid Gland - embryology Thyroid Gland - metabolism Thyroid hormones Thyroid Nuclear Factor 1 thyroid transcription factor 1 thyrotropin thyrotropin receptor Thyroxine - biosynthesis Thyroxine - genetics Time Factors transcription factors Transcription Factors - genetics |
| title | Ontogenic expression profiles of thyroid-specific genes in embryonic and hatching chicks |
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