Differential gene expression of soluble CD8+ T‐cell mediated suppression of HIV replication in three older children
Suppression of human immunodeficiency virus (HIV) replication by CD8+ T‐cells (CD8 suppression) contributes to survival in adults and children
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| Veröffentlicht in: | Journal of medical virology 2011, Vol.83 (1), p.24-32 |
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| container_title | Journal of medical virology |
| container_volume | 83 |
| creator | Katz, Ben Z Salimi, Babak Gadd, Samantha L Huang, Chiang‐Ching Kabat, William J Kersey, Donna McCabe, Chris Heald‐Sargent, Taylor Katz, Elyssa D Yogev, Ram |
| description | Suppression of human immunodeficiency virus (HIV) replication by CD8+ T‐cells (CD8 suppression) contributes to survival in adults and children |
| doi_str_mv | 10.1002/jmv.21933 |
| format | Article |
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Soluble CD8 suppression can also be seen in some older children with AIDS. The factor responsible, CD8‐derived antiviral factor (CAF), acts at the level of HIV RNA transcription. Differential gene expression techniques have been used to define the gene(s) mediating this phenomenon in adults. Recently, CAF has been linked to exosomes secreted by CD8+ T‐cells. To compare the gene expression profiles from pediatric patients with each other, with those reported in 2 previous studies in adults and in those reportedly related to exosomes, we used differential gene expression to study three older children with HIV infection, one who did demonstrate soluble CD‐8 suppression and two who did not. Eighteen differentially expressed genes were also seen in one adult study (P = 0.002, χ² test), and 38 such genes (P < 0.0001, χ² test) in a second adult study. In addition, two exosome components and some RNA's related to exosomal proteins were also differentially expressed. In children with HIV infection, we found significant differentially expressed genes that correlated to those previously reported in two studies in adults. Our data also lends some support to the recent identification of CAF with exosomes secreted by CD8+ T‐cells. J. Med. Virol. 83:24-32, 2011.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.21933</identifier><identifier>PMID: 21108336</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Biological and medical sciences ; CD8-derived antiviral factor ; CD8-Positive T-Lymphocytes - immunology ; Child ; differential gene expression ; Exosomes - enzymology ; Exosomes - immunology ; Fundamental and applied biological sciences. Psychology ; gene array ; Gene expression ; Gene Expression Profiling ; Genetics ; HIV ; HIV Infections - immunology ; HIV-1 - immunology ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical research ; Medical sciences ; Microbiology ; Miscellaneous ; pediatric HIV infcetion ; soluble CD8 suppression ; Transcription, Genetic ; Viral diseases ; Virology ; Virus Replication</subject><ispartof>Journal of medical virology, 2011, Vol.83 (1), p.24-32</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2010 Wiley-Liss, Inc.</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4773-580ec5e81d2c591d4807fb1e6145b61716975e38fc8337e4f5d7e5d26dbcd5d3</citedby><cites>FETCH-LOGICAL-c4773-580ec5e81d2c591d4807fb1e6145b61716975e38fc8337e4f5d7e5d26dbcd5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.21933$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.21933$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23784249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21108336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katz, Ben Z</creatorcontrib><creatorcontrib>Salimi, Babak</creatorcontrib><creatorcontrib>Gadd, Samantha L</creatorcontrib><creatorcontrib>Huang, Chiang‐Ching</creatorcontrib><creatorcontrib>Kabat, William J</creatorcontrib><creatorcontrib>Kersey, Donna</creatorcontrib><creatorcontrib>McCabe, Chris</creatorcontrib><creatorcontrib>Heald‐Sargent, Taylor</creatorcontrib><creatorcontrib>Katz, Elyssa D</creatorcontrib><creatorcontrib>Yogev, Ram</creatorcontrib><title>Differential gene expression of soluble CD8+ T‐cell mediated suppression of HIV replication in three older children</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Suppression of human immunodeficiency virus (HIV) replication by CD8+ T‐cells (CD8 suppression) contributes to survival in adults and children <1 year. Soluble CD8 suppression can also be seen in some older children with AIDS. The factor responsible, CD8‐derived antiviral factor (CAF), acts at the level of HIV RNA transcription. Differential gene expression techniques have been used to define the gene(s) mediating this phenomenon in adults. Recently, CAF has been linked to exosomes secreted by CD8+ T‐cells. To compare the gene expression profiles from pediatric patients with each other, with those reported in 2 previous studies in adults and in those reportedly related to exosomes, we used differential gene expression to study three older children with HIV infection, one who did demonstrate soluble CD‐8 suppression and two who did not. Eighteen differentially expressed genes were also seen in one adult study (P = 0.002, χ² test), and 38 such genes (P < 0.0001, χ² test) in a second adult study. In addition, two exosome components and some RNA's related to exosomal proteins were also differentially expressed. In children with HIV infection, we found significant differentially expressed genes that correlated to those previously reported in two studies in adults. Our data also lends some support to the recent identification of CAF with exosomes secreted by CD8+ T‐cells. J. Med. Virol. 83:24-32, 2011.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>CD8-derived antiviral factor</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>differential gene expression</subject><subject>Exosomes - enzymology</subject><subject>Exosomes - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene array</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genetics</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>HIV-1 - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>pediatric HIV infcetion</subject><subject>soluble CD8 suppression</subject><subject>Transcription, Genetic</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Virus Replication</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctu1DAUANAIgehQWPADYAkhQCitb_xKlmhKH6iAgKFIbCyPfdN6yCSDnUC74xP4Rr4ED5kWhAQrS9a57yy7C3QHKC12F8svOwVUjF3LJkArmVdUwfVsQoHLXEoQW9mtGBeU0rIqipvZVgFAS8bkJBv2fF1jwLb3piGn2CLB81XAGH3Xkq4msWuGeYNkulc-JbMf375bbBqyROdNj47EYfWnPjw6IQFXjbemX3_5lvRnAZF0jcNA7JlvXCp2O7tRmybinc27nc32n8-mh_nx64Oj6bPj3HKlWC5KilZgCa6wogLHS6rqOaAELuYSFMhKCWRlbdMwCnktnELhCunm1gnHtrNHY9pV6D4PGHu99HHdv2mxG6IugXPJBPAkH_9XgpAUoKIFTfTBX3TRDaFNYyTFBS2FYjKpJ6OyoYsxYK1XwS9NuNBA9fpoOh1N_zpasvc2GYd5WuyVvLxSAg83wERrmjqY1vr42zFV8oJXye2O7qtv8OLfFfWLlyeXpfMxwscez68iTPikpWJK6A-vDvRMvSnfftwXel3h_uhr02lzGlIX798VFBiFKq1RcvYTMvzFxg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Katz, Ben Z</creator><creator>Salimi, Babak</creator><creator>Gadd, Samantha L</creator><creator>Huang, Chiang‐Ching</creator><creator>Kabat, William J</creator><creator>Kersey, Donna</creator><creator>McCabe, Chris</creator><creator>Heald‐Sargent, Taylor</creator><creator>Katz, Elyssa D</creator><creator>Yogev, Ram</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Differential gene expression of soluble CD8+ T‐cell mediated suppression of HIV replication in three older children</title><author>Katz, Ben Z ; Salimi, Babak ; Gadd, Samantha L ; Huang, Chiang‐Ching ; Kabat, William J ; Kersey, Donna ; McCabe, Chris ; Heald‐Sargent, Taylor ; Katz, Elyssa D ; Yogev, Ram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4773-580ec5e81d2c591d4807fb1e6145b61716975e38fc8337e4f5d7e5d26dbcd5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>CD8-derived antiviral factor</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Child</topic><topic>differential gene expression</topic><topic>Exosomes - enzymology</topic><topic>Exosomes - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene array</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Genetics</topic><topic>HIV</topic><topic>HIV Infections - immunology</topic><topic>HIV-1 - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>pediatric HIV infcetion</topic><topic>soluble CD8 suppression</topic><topic>Transcription, Genetic</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katz, Ben Z</creatorcontrib><creatorcontrib>Salimi, Babak</creatorcontrib><creatorcontrib>Gadd, Samantha L</creatorcontrib><creatorcontrib>Huang, Chiang‐Ching</creatorcontrib><creatorcontrib>Kabat, William J</creatorcontrib><creatorcontrib>Kersey, Donna</creatorcontrib><creatorcontrib>McCabe, Chris</creatorcontrib><creatorcontrib>Heald‐Sargent, Taylor</creatorcontrib><creatorcontrib>Katz, Elyssa D</creatorcontrib><creatorcontrib>Yogev, Ram</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katz, Ben Z</au><au>Salimi, Babak</au><au>Gadd, Samantha L</au><au>Huang, Chiang‐Ching</au><au>Kabat, William J</au><au>Kersey, Donna</au><au>McCabe, Chris</au><au>Heald‐Sargent, Taylor</au><au>Katz, Elyssa D</au><au>Yogev, Ram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential gene expression of soluble CD8+ T‐cell mediated suppression of HIV replication in three older children</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2011</date><risdate>2011</risdate><volume>83</volume><issue>1</issue><spage>24</spage><epage>32</epage><pages>24-32</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Suppression of human immunodeficiency virus (HIV) replication by CD8+ T‐cells (CD8 suppression) contributes to survival in adults and children <1 year. Soluble CD8 suppression can also be seen in some older children with AIDS. The factor responsible, CD8‐derived antiviral factor (CAF), acts at the level of HIV RNA transcription. Differential gene expression techniques have been used to define the gene(s) mediating this phenomenon in adults. Recently, CAF has been linked to exosomes secreted by CD8+ T‐cells. To compare the gene expression profiles from pediatric patients with each other, with those reported in 2 previous studies in adults and in those reportedly related to exosomes, we used differential gene expression to study three older children with HIV infection, one who did demonstrate soluble CD‐8 suppression and two who did not. Eighteen differentially expressed genes were also seen in one adult study (P = 0.002, χ² test), and 38 such genes (P < 0.0001, χ² test) in a second adult study. In addition, two exosome components and some RNA's related to exosomal proteins were also differentially expressed. In children with HIV infection, we found significant differentially expressed genes that correlated to those previously reported in two studies in adults. Our data also lends some support to the recent identification of CAF with exosomes secreted by CD8+ T‐cells. J. Med. Virol. 83:24-32, 2011.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21108336</pmid><doi>10.1002/jmv.21933</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences CD8-derived antiviral factor CD8-Positive T-Lymphocytes - immunology Child differential gene expression Exosomes - enzymology Exosomes - immunology Fundamental and applied biological sciences. Psychology gene array Gene expression Gene Expression Profiling Genetics HIV HIV Infections - immunology HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical research Medical sciences Microbiology Miscellaneous pediatric HIV infcetion soluble CD8 suppression Transcription, Genetic Viral diseases Virology Virus Replication |
| title | Differential gene expression of soluble CD8+ T‐cell mediated suppression of HIV replication in three older children |
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