The binding of vincristine, vinblastine and colchicine to tubulin

Preparations of tubulin were examined for their ability to bind vincristine, vinblastine, and colchicine, as measured by adsorption on DEAE impregnated filter paper. Vincristine and vinblastine were found to bind very rapidly with tubulin (4 hr). When varying concentrations of the alkaloids were emp...

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Veröffentlicht in:	Biochemical and biophysical research communications 1972-05, Vol.47 (4), p.685-691
Hauptverfasser:	Owellen, Richard J., Owens, Albert H., Donigian, Douglas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Brain Colchicine Filtration Microtubules Nerve Tissue Proteins Protein Binding Swine Time Factors Tritium Vinblastine Vincristine
Online-Zugang:	Volltext
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