Diuretic action of benemid: Its effect upon the urinary excretion of sodium, chloride, potassium and water in edematous subjects
1. 1. In thirteen subjects with uncomplicated congestive heart failure benemid in dosage of 4 gm. daily produced a significant diuretic response. The mean increment of water excreted on the day of maximal response was 1,330 cc., of sodium 91 mEq. and of chloride 76 mEq./24 hours. A fourteenth subjec...
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| Veröffentlicht in: | The American journal of medicine 1955-01, Vol.18 (2), p.259-266 |
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| container_title | The American journal of medicine |
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| creator | Bronsky, David Dubin, Alvin Kushner, Daniel S. |
| description | 1.
1. In thirteen subjects with uncomplicated congestive heart failure benemid in dosage of 4 gm. daily produced a significant diuretic response. The mean increment of water excreted on the day of maximal response was 1,330 cc., of sodium 91 mEq. and of chloride 76 mEq./24 hours. A fourteenth subject with associated gout and renal disease showed a lesser but significant response. Diuresis occurred in most instances on either the first or second day of drug administration.
2.
2. Water diuresis without enhancement of sodium or chloride excretion occurred in seven other subjects. Failure of diuresis to occur in the remaining five subjects was associated with the presence of hepatic disease, renal disease, hyponatremia and hyponatruria.
3.
3. It is postulated that benemid-induced diuresis is the result of decreased tubular reabsorption of water, sodium and chloride. |
| doi_str_mv | 10.1016/0002-9343(55)90241-2 |
| format | Article |
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1. In thirteen subjects with uncomplicated congestive heart failure benemid in dosage of 4 gm. daily produced a significant diuretic response. The mean increment of water excreted on the day of maximal response was 1,330 cc., of sodium 91 mEq. and of chloride 76 mEq./24 hours. A fourteenth subject with associated gout and renal disease showed a lesser but significant response. Diuresis occurred in most instances on either the first or second day of drug administration.
2.
2. Water diuresis without enhancement of sodium or chloride excretion occurred in seven other subjects. Failure of diuresis to occur in the remaining five subjects was associated with the presence of hepatic disease, renal disease, hyponatremia and hyponatruria.
3.
3. It is postulated that benemid-induced diuresis is the result of decreased tubular reabsorption of water, sodium and chloride.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(55)90241-2</identifier><identifier>PMID: 13228449</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Diuresis - drug effects ; Diuretics ; Edema - therapy ; Electrolytes - urine ; Heart Failure - therapy ; Humans ; Kidney Diseases ; Old Medline ; Potassium ; Probenecid - therapeutic use ; Sodium ; Water</subject><ispartof>The American journal of medicine, 1955-01, Vol.18 (2), p.259-266</ispartof><rights>1955</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(55)90241-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13228449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bronsky, David</creatorcontrib><creatorcontrib>Dubin, Alvin</creatorcontrib><creatorcontrib>Kushner, Daniel S.</creatorcontrib><title>Diuretic action of benemid: Its effect upon the urinary excretion of sodium, chloride, potassium and water in edematous subjects</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>1.
1. In thirteen subjects with uncomplicated congestive heart failure benemid in dosage of 4 gm. daily produced a significant diuretic response. The mean increment of water excreted on the day of maximal response was 1,330 cc., of sodium 91 mEq. and of chloride 76 mEq./24 hours. A fourteenth subject with associated gout and renal disease showed a lesser but significant response. Diuresis occurred in most instances on either the first or second day of drug administration.
2.
2. Water diuresis without enhancement of sodium or chloride excretion occurred in seven other subjects. Failure of diuresis to occur in the remaining five subjects was associated with the presence of hepatic disease, renal disease, hyponatremia and hyponatruria.
3.
3. It is postulated that benemid-induced diuresis is the result of decreased tubular reabsorption of water, sodium and chloride.</description><subject>Diuresis - drug effects</subject><subject>Diuretics</subject><subject>Edema - therapy</subject><subject>Electrolytes - urine</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>Kidney Diseases</subject><subject>Old Medline</subject><subject>Potassium</subject><subject>Probenecid - therapeutic use</subject><subject>Sodium</subject><subject>Water</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1955</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1LAzEQhoMotlb_gUhOouBqPrcbD4LUTxC86Dlkk1lM6e7WJOvHzZ9uatXTMDPPDO_Mi9A-JaeU0PKMEMIKxQU_kvJYESZowTbQmEopiykt2SYa_yMjtBPjPKdEyXIbjShnrBJCjdHXlR8CJG-xscn3He4bXEMHrXfn-D5FDE0DNuFhmXvpBfAQfGfCJ4YPu5pbT8Te-aE9wfZl0Qfv4AQv-2RizEVsOoffTYKAfYfBQWtSP0Qch3qeF8ddtNWYRYS93zhBzzfXT7O74uHx9n52-VAAK0UqJKNKTRtiGZlWlbFgnCgVMYyCI9ZJoAyUkIIx29S0FFBZR2vOKqNqJSXnE3S43rsM_esAMenWRwuLhekg69EVFZyLqszgwS841C04vQy-zQfrv59l4GINQJb75iHoaD10FpwP-SLteq8p0SuT9MoBvXJAS6l_TNKMfwNLD4QX</recordid><startdate>19550101</startdate><enddate>19550101</enddate><creator>Bronsky, David</creator><creator>Dubin, Alvin</creator><creator>Kushner, Daniel S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19550101</creationdate><title>Diuretic action of benemid: Its effect upon the urinary excretion of sodium, chloride, potassium and water in edematous subjects</title><author>Bronsky, David ; Dubin, Alvin ; Kushner, Daniel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e264t-521997f0c20788acead4690a21ed0cd5e12e945422cfb164e8cd1b328a9b95533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1955</creationdate><topic>Diuresis - drug effects</topic><topic>Diuretics</topic><topic>Edema - therapy</topic><topic>Electrolytes - urine</topic><topic>Heart Failure - therapy</topic><topic>Humans</topic><topic>Kidney Diseases</topic><topic>Old Medline</topic><topic>Potassium</topic><topic>Probenecid - therapeutic use</topic><topic>Sodium</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bronsky, David</creatorcontrib><creatorcontrib>Dubin, Alvin</creatorcontrib><creatorcontrib>Kushner, Daniel S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bronsky, David</au><au>Dubin, Alvin</au><au>Kushner, Daniel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diuretic action of benemid: Its effect upon the urinary excretion of sodium, chloride, potassium and water in edematous subjects</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1955-01-01</date><risdate>1955</risdate><volume>18</volume><issue>2</issue><spage>259</spage><epage>266</epage><pages>259-266</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>1.
1. In thirteen subjects with uncomplicated congestive heart failure benemid in dosage of 4 gm. daily produced a significant diuretic response. The mean increment of water excreted on the day of maximal response was 1,330 cc., of sodium 91 mEq. and of chloride 76 mEq./24 hours. A fourteenth subject with associated gout and renal disease showed a lesser but significant response. Diuresis occurred in most instances on either the first or second day of drug administration.
2.
2. Water diuresis without enhancement of sodium or chloride excretion occurred in seven other subjects. Failure of diuresis to occur in the remaining five subjects was associated with the presence of hepatic disease, renal disease, hyponatremia and hyponatruria.
3.
3. It is postulated that benemid-induced diuresis is the result of decreased tubular reabsorption of water, sodium and chloride.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>13228449</pmid><doi>10.1016/0002-9343(55)90241-2</doi><tpages>8</tpages></addata></record> |
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| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Diuresis - drug effects Diuretics Edema - therapy Electrolytes - urine Heart Failure - therapy Humans Kidney Diseases Old Medline Potassium Probenecid - therapeutic use Sodium Water |
| title | Diuretic action of benemid: Its effect upon the urinary excretion of sodium, chloride, potassium and water in edematous subjects |
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