Extravascular coronary resistance and its relation to microcirculation: Influence of heart rate, end-diastolic pressure and maximal rate of rise of intraventricular pressure

The effect of heart rate, left intraventricular end-diastolic pressure and maximal rate of left intraventricular pressure rise on the extra-vascular resistance to coronary blood flow was evaluated in 19 anesthetized dogs during maximal dilatation of the coronary arteries. The heart was externally st...

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Veröffentlicht in:	The American journal of cardiology 1972-05, Vol.29 (5), p.598-603
Hauptverfasser:	Raff, Werner Karl, Kosche, Friedrich, Lochner, Wilhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Animals Arteries - drug effects Blood Circulation Blood Pressure Coronary Circulation Coronary Vessels - physiology Dilatation Dogs Electric Stimulation Heart Rate Heart Ventricles - drug effects Hematocrit Isoproterenol - pharmacology Microcirculation Vascular Resistance
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Zusammenfassung:	The effect of heart rate, left intraventricular end-diastolic pressure and maximal rate of left intraventricular pressure rise on the extra-vascular resistance to coronary blood flow was evaluated in 19 anesthetized dogs during maximal dilatation of the coronary arteries. The heart was externally stimulated after elimination of the sinus node. It was found that extravascular support increases with increases in heart rate, end-diastolic pressure and maximal rate of rise of left intraventricular pressure.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/0002-9149(72)90159-2