Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients
Electron microscopic studies revealed distinctive abnormalities in operatively resected myocardium from the left ventricular outflow tract in 14 patients with idiopathic hypertrophic subaortic stenosis. Bundles of muscle cells were severely disorganized, with cells running in different directions in...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1972-04, Vol.45 (4), p.769-792 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | Ferrans, V J Morrow, A G Roberts, W C |
| description | Electron microscopic studies revealed distinctive abnormalities in operatively resected myocardium from the left ventricular outflow tract in 14 patients with idiopathic hypertrophic subaortic stenosis. Bundles of muscle cells were severely disorganized, with cells running in different directions instead of in parallel. Muscle cells were wider and shorter than in hypertrophy due to other causes and showed increased cellular branching, extensive side-to-side intercellular junctions, widened Z bands, and evidence of formation of new sarcomeres. Some myofibrils were oriented obliquely or perpendicular to the longitudinal axes of the cells and some myofilaments that originated from a single Z band inserted into Z bands of other myofibrils. Examination of left ventricular apical myocardium in two patients revealed hypertrophied but normally arranged muscle cells. It is concluded that abnormal architecture of muscle cells is the basic morphologic feature of idiopathic hypertrophic subaortic stenosis. |
| doi_str_mv | 10.1161/01.CIR.45.4.769 |
| format | Article |
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A study of operatively excised left ventricular outflow tract muscle in 14 patients</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Ferrans, V J ; Morrow, A G ; Roberts, W C</creator><creatorcontrib>Ferrans, V J ; Morrow, A G ; Roberts, W C</creatorcontrib><description>Electron microscopic studies revealed distinctive abnormalities in operatively resected myocardium from the left ventricular outflow tract in 14 patients with idiopathic hypertrophic subaortic stenosis. Bundles of muscle cells were severely disorganized, with cells running in different directions instead of in parallel. Muscle cells were wider and shorter than in hypertrophy due to other causes and showed increased cellular branching, extensive side-to-side intercellular junctions, widened Z bands, and evidence of formation of new sarcomeres. Some myofibrils were oriented obliquely or perpendicular to the longitudinal axes of the cells and some myofilaments that originated from a single Z band inserted into Z bands of other myofibrils. Examination of left ventricular apical myocardium in two patients revealed hypertrophied but normally arranged muscle cells. It is concluded that abnormal architecture of muscle cells is the basic morphologic feature of idiopathic hypertrophic subaortic stenosis.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.45.4.769</identifier><identifier>PMID: 4335705</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Cardiomyopathy, Hypertrophic - pathology ; Cell Nucleus ; Female ; Glycogen - metabolism ; Heart Ventricles ; Humans ; Inclusion Bodies ; Intercellular Junctions ; Lysosomes ; Male ; Middle Aged ; Mitochondria, Muscle ; Myocardium - pathology ; Myofibrils ; Papillary Muscles - pathology ; Ribosomes ; Sarcolemma ; Sarcoplasmic Reticulum</subject><ispartof>Circulation (New York, N.Y.), 1972-04, Vol.45 (4), p.769-792</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4335705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrans, V J</creatorcontrib><creatorcontrib>Morrow, A G</creatorcontrib><creatorcontrib>Roberts, W C</creatorcontrib><title>Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Electron microscopic studies revealed distinctive abnormalities in operatively resected myocardium from the left ventricular outflow tract in 14 patients with idiopathic hypertrophic subaortic stenosis. Bundles of muscle cells were severely disorganized, with cells running in different directions instead of in parallel. Muscle cells were wider and shorter than in hypertrophy due to other causes and showed increased cellular branching, extensive side-to-side intercellular junctions, widened Z bands, and evidence of formation of new sarcomeres. Some myofibrils were oriented obliquely or perpendicular to the longitudinal axes of the cells and some myofilaments that originated from a single Z band inserted into Z bands of other myofibrils. Examination of left ventricular apical myocardium in two patients revealed hypertrophied but normally arranged muscle cells. It is concluded that abnormal architecture of muscle cells is the basic morphologic feature of idiopathic hypertrophic subaortic stenosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cardiomyopathy, Hypertrophic - pathology</subject><subject>Cell Nucleus</subject><subject>Female</subject><subject>Glycogen - metabolism</subject><subject>Heart Ventricles</subject><subject>Humans</subject><subject>Inclusion Bodies</subject><subject>Intercellular Junctions</subject><subject>Lysosomes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitochondria, Muscle</subject><subject>Myocardium - pathology</subject><subject>Myofibrils</subject><subject>Papillary Muscles - pathology</subject><subject>Ribosomes</subject><subject>Sarcolemma</subject><subject>Sarcoplasmic Reticulum</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtrGzEUhUVJcR2366wCWmU3k9Frxloa0zSGlEJJ1kKjuYNVZGuqh9v5L_2xlROT1TkXvnvO4iB0Q5qakJbcN6Te7n7WXNS87lr5AS2JoLzigskrtGyaRlYdo_QTuo7xVzlb1okFWnDGRNeIJfr3ffZGh8Fqh7NLQccUskk5ALZHbAfrJ5321uD9PEFIwU_nI-Ze-5DOLsHRRxtrvCk-DzP2I_YF1cmewM0Y_hobYcAOxoRPcEzBmux0wD6n0fk_uHSahA85GvfaSTgulbaQ8TP6OGoX4ctFV-jl4evz9rF6-vFtt908VYau21T1DEDwTjIjqRBdy0ESSosWDwOQQa410A4MEOgl0aY3fb_mspWUyG5kbIXu3nKn4H9niEkdbDTgnD6Cz1GtCZNSMlrA-zfQBB9jgFFNwR50mBVp1HkP1RBV9lBcKK7KHuXj9hKd-wMM7_xlAPYfr_yKvg</recordid><startdate>197204</startdate><enddate>197204</enddate><creator>Ferrans, V J</creator><creator>Morrow, A G</creator><creator>Roberts, W C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197204</creationdate><title>Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients</title><author>Ferrans, V J ; Morrow, A G ; Roberts, W C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-b3ee54793c9255764e9122764576ede1d98ae27ece1eb91acbcbb849692197f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cardiomyopathy, Hypertrophic - pathology</topic><topic>Cell Nucleus</topic><topic>Female</topic><topic>Glycogen - metabolism</topic><topic>Heart Ventricles</topic><topic>Humans</topic><topic>Inclusion Bodies</topic><topic>Intercellular Junctions</topic><topic>Lysosomes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitochondria, Muscle</topic><topic>Myocardium - pathology</topic><topic>Myofibrils</topic><topic>Papillary Muscles - pathology</topic><topic>Ribosomes</topic><topic>Sarcolemma</topic><topic>Sarcoplasmic Reticulum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrans, V J</creatorcontrib><creatorcontrib>Morrow, A G</creatorcontrib><creatorcontrib>Roberts, W C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrans, V J</au><au>Morrow, A G</au><au>Roberts, W C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1972-04</date><risdate>1972</risdate><volume>45</volume><issue>4</issue><spage>769</spage><epage>792</epage><pages>769-792</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Electron microscopic studies revealed distinctive abnormalities in operatively resected myocardium from the left ventricular outflow tract in 14 patients with idiopathic hypertrophic subaortic stenosis. Bundles of muscle cells were severely disorganized, with cells running in different directions instead of in parallel. Muscle cells were wider and shorter than in hypertrophy due to other causes and showed increased cellular branching, extensive side-to-side intercellular junctions, widened Z bands, and evidence of formation of new sarcomeres. Some myofibrils were oriented obliquely or perpendicular to the longitudinal axes of the cells and some myofilaments that originated from a single Z band inserted into Z bands of other myofibrils. Examination of left ventricular apical myocardium in two patients revealed hypertrophied but normally arranged muscle cells. It is concluded that abnormal architecture of muscle cells is the basic morphologic feature of idiopathic hypertrophic subaortic stenosis.</abstract><cop>United States</cop><pmid>4335705</pmid><doi>10.1161/01.CIR.45.4.769</doi><tpages>24</tpages></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 1972-04, Vol.45 (4), p.769-792 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adolescent Adult Cardiomyopathy, Hypertrophic - pathology Cell Nucleus Female Glycogen - metabolism Heart Ventricles Humans Inclusion Bodies Intercellular Junctions Lysosomes Male Middle Aged Mitochondria, Muscle Myocardium - pathology Myofibrils Papillary Muscles - pathology Ribosomes Sarcolemma Sarcoplasmic Reticulum |
| title | Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients |
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