Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin
The prognosis for 115 rheumatic fever patients subsequently receiving regular intramuscular penicillin prophylaxis for at least 5 years was studied. Average follow-up was 9.3 years, and 57 patients were followed for 10 years or longer. Of the 79 patients with acute mitral regurgitation, 70% lost the...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1972-03, Vol.45 (3), p.543-551 |
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| container_end_page | 551 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | Tompkins, D G Boxerbaum, B Liebman, J |
| description | The prognosis for 115 rheumatic fever patients subsequently receiving regular intramuscular penicillin prophylaxis for at least 5 years was studied. Average follow-up was 9.3 years, and 57 patients were followed for 10 years or longer. Of the 79 patients with acute mitral regurgitation, 70% lost their murmur from 4 days to 8.5 years after it was first heard. This is in contrast to those with acute aortic regurgitation which persisted in 73%. No patient developed mitral or aortic stenosis: this suggests that regular prophylaxis may prevent the development of stenosis. Congestive failure, cardiomegaly, and arrhythmia correlated closely with persistence of murmurs, but increased P-R interval, acute QRS or T-voltage variation or both, and ST-T abnormalities did not. |
| doi_str_mv | 10.1161/01.CIR.45.3.543 |
| format | Article |
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Average follow-up was 9.3 years, and 57 patients were followed for 10 years or longer. Of the 79 patients with acute mitral regurgitation, 70% lost their murmur from 4 days to 8.5 years after it was first heard. This is in contrast to those with acute aortic regurgitation which persisted in 73%. No patient developed mitral or aortic stenosis: this suggests that regular prophylaxis may prevent the development of stenosis. 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Congestive failure, cardiomegaly, and arrhythmia correlated closely with persistence of murmurs, but increased P-R interval, acute QRS or T-voltage variation or both, and ST-T abnormalities did not.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Endocarditis, Subacute Bacterial - prevention & control</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Auscultation</subject><subject>Humans</subject><subject>Male</subject><subject>Mitral Valve Insufficiency - prevention & control</subject><subject>Mitral Valve Stenosis - prevention & control</subject><subject>Penicillin G Benzathine - therapeutic use</subject><subject>Prognosis</subject><subject>Rheumatic Fever - drug therapy</subject><subject>Rheumatic Heart Disease - prevention & control</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LxDAUxIMo67p69iTk5K3dfLbdoyx-LCwIoueQZF-7kTatSSvoX290F09vBmYG3g-ha0pySgu6JDRfb15yIXOeS8FP0JxKJjIh-eoUzQkhq6zkjJ2jixjfky14KWdoJgllTPA5gm3vm2yE0OEh9I3vo4u4r3HYw9Tp0VlcwycEPCQNfow4gAX36XyTVDO1OmDnx6C7Kdo_Z8B_63HvPOABvLOubZ2_RGe1biNcHe8CvT3cv66fsu3z42Z9t82sKOSYlSCrujJ6ZzQp6ppJYkpLSs6ZZYU2jK0YYcZSA5WhFggviCyZECVUVckKwRfo9rCbfvmYII6qc9FC22oP_RRVRXlVccpTcHkI2tDHGKBWQ3CdDl-KEvULVhGqElglpOIqgU2Nm-P0ZDrY_eePJPkPXBp1gA</recordid><startdate>197203</startdate><enddate>197203</enddate><creator>Tompkins, D G</creator><creator>Boxerbaum, B</creator><creator>Liebman, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197203</creationdate><title>Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin</title><author>Tompkins, D G ; Boxerbaum, B ; Liebman, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-7e58f8badba06ff250b7c07332c26ab229202bc1be8b1ce0360572447e8872643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Endocarditis, Subacute Bacterial - prevention & control</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Auscultation</topic><topic>Humans</topic><topic>Male</topic><topic>Mitral Valve Insufficiency - prevention & control</topic><topic>Mitral Valve Stenosis - prevention & control</topic><topic>Penicillin G Benzathine - therapeutic use</topic><topic>Prognosis</topic><topic>Rheumatic Fever - drug therapy</topic><topic>Rheumatic Heart Disease - prevention & control</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tompkins, D G</creatorcontrib><creatorcontrib>Boxerbaum, B</creatorcontrib><creatorcontrib>Liebman, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tompkins, D G</au><au>Boxerbaum, B</au><au>Liebman, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1972-03</date><risdate>1972</risdate><volume>45</volume><issue>3</issue><spage>543</spage><epage>551</epage><pages>543-551</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>The prognosis for 115 rheumatic fever patients subsequently receiving regular intramuscular penicillin prophylaxis for at least 5 years was studied. 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| ispartof | Circulation (New York, N.Y.), 1972-03, Vol.45 (3), p.543-551 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adolescent Adult Child Endocarditis, Subacute Bacterial - prevention & control Female Follow-Up Studies Heart Auscultation Humans Male Mitral Valve Insufficiency - prevention & control Mitral Valve Stenosis - prevention & control Penicillin G Benzathine - therapeutic use Prognosis Rheumatic Fever - drug therapy Rheumatic Heart Disease - prevention & control Time Factors |
| title | Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin |
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