Problems in absorption and immunosuppression after entire intestinal allotransplantation
Orthotopic entire small intestine allografts were transplanted in twenty dogs. Ten of these animals received immunosuppressive drugs. Allograft function was compared with that of other dogs subjected to complete intestinal denervation and lymphatic interruption. Dogs with denervated intestine showed...
Gespeichert in:
| Veröffentlicht in: | The American journal of surgery 1972-03, Vol.123 (3), p.297-303 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 303 |
|---|---|
| container_issue | 3 |
| container_start_page | 297 |
| container_title | The American journal of surgery |
| container_volume | 123 |
| creator | Ruiz, J.Octavio Uchida, Hisanori Schultz, Leonard S. Lillehei, Richard C. |
| description | Orthotopic entire small intestine allografts were transplanted in twenty dogs. Ten of these animals received immunosuppressive drugs. Allograft function was compared with that of other dogs subjected to complete intestinal denervation and lymphatic interruption.
Dogs with denervated intestine showed decreased d-xylose absorption with reversal to normal rates within four months. Groups receiving allografts also showed depressed function which persisted for up to five weeks.
Interestingly, dogs with untreated allografts showed no significant pathologic changes even though survival ranged from one to four weeks. In contrast, some dogs who received immunosuppressive drugs showed manifestations of organ rejection. Although we could not clearly demonstrate a graft versus host reaction in untreated allografts, it appears that entire small intestinal allografts, in the absence of these immunosuppressive drugs, can precipitate such a reaction. This phenomenon is believed to be related to the abundant lymphatic tissue found in the intestine. |
| doi_str_mv | 10.1016/0002-9610(72)90289-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81385613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0002961072902899</els_id><sourcerecordid>81385613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-4f52021508032cf60bf6023e72948db3d844b1fcf5aaf23f07703fc52357c3f53</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo67r6DxR6Ej1U89G0yUWQxS9Y0IOCt5CmCUTapCap4L83dRePHsLMZOZ9M3kAOEXwCkFUX0MIcclrBC8afMkhZrzke2CJWMNLxBjZB8u_kUNwFONHLhGqyAIsaE44qZbg_SX4ttdDLKwrZBt9GJP1OXVdYYdhcj5O4xh0jL-3JulQaJds0FmQdEzWyb6Qfe9TkC6OvXRJzg7H4MDIPuqTXVyBt_u71_VjuXl-eFrfbkpFaJPKylAMMaKQQYKVqWGbDya6wbxiXUs6VlUtMspQKQ0mBjYNJEZRnNWKGEpW4HzrOwb_OeWFxGCj0n1eRPspCoYIozUiebDaDqrgYwzaiDHYQYZvgaCYgYqZlphpiSbHGajgWXa285_aQXd_oh3B3L_Z9nX-5JfVQURltVO6y4xUEp23_z_wA7eJhjE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81385613</pqid></control><display><type>article</type><title>Problems in absorption and immunosuppression after entire intestinal allotransplantation</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ruiz, J.Octavio ; Uchida, Hisanori ; Schultz, Leonard S. ; Lillehei, Richard C.</creator><creatorcontrib>Ruiz, J.Octavio ; Uchida, Hisanori ; Schultz, Leonard S. ; Lillehei, Richard C.</creatorcontrib><description>Orthotopic entire small intestine allografts were transplanted in twenty dogs. Ten of these animals received immunosuppressive drugs. Allograft function was compared with that of other dogs subjected to complete intestinal denervation and lymphatic interruption.
Dogs with denervated intestine showed decreased d-xylose absorption with reversal to normal rates within four months. Groups receiving allografts also showed depressed function which persisted for up to five weeks.
Interestingly, dogs with untreated allografts showed no significant pathologic changes even though survival ranged from one to four weeks. In contrast, some dogs who received immunosuppressive drugs showed manifestations of organ rejection. Although we could not clearly demonstrate a graft versus host reaction in untreated allografts, it appears that entire small intestinal allografts, in the absence of these immunosuppressive drugs, can precipitate such a reaction. This phenomenon is believed to be related to the abundant lymphatic tissue found in the intestine.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/0002-9610(72)90289-9</identifier><identifier>PMID: 5011934</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Azathioprine - therapeutic use ; Body Weight ; Dogs ; Graft Rejection ; Hematocrit ; Immunosuppression ; Intestinal Absorption ; Intestinal Mucosa - metabolism ; Intestine, Small - transplantation ; Leukocyte Count ; Prednisone - therapeutic use ; Time Factors ; Transplantation Immunology ; Transplantation, Homologous ; Xylose - metabolism</subject><ispartof>The American journal of surgery, 1972-03, Vol.123 (3), p.297-303</ispartof><rights>1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-4f52021508032cf60bf6023e72948db3d844b1fcf5aaf23f07703fc52357c3f53</citedby><cites>FETCH-LOGICAL-c357t-4f52021508032cf60bf6023e72948db3d844b1fcf5aaf23f07703fc52357c3f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9610(72)90289-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5011934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz, J.Octavio</creatorcontrib><creatorcontrib>Uchida, Hisanori</creatorcontrib><creatorcontrib>Schultz, Leonard S.</creatorcontrib><creatorcontrib>Lillehei, Richard C.</creatorcontrib><title>Problems in absorption and immunosuppression after entire intestinal allotransplantation</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Orthotopic entire small intestine allografts were transplanted in twenty dogs. Ten of these animals received immunosuppressive drugs. Allograft function was compared with that of other dogs subjected to complete intestinal denervation and lymphatic interruption.
Dogs with denervated intestine showed decreased d-xylose absorption with reversal to normal rates within four months. Groups receiving allografts also showed depressed function which persisted for up to five weeks.
Interestingly, dogs with untreated allografts showed no significant pathologic changes even though survival ranged from one to four weeks. In contrast, some dogs who received immunosuppressive drugs showed manifestations of organ rejection. Although we could not clearly demonstrate a graft versus host reaction in untreated allografts, it appears that entire small intestinal allografts, in the absence of these immunosuppressive drugs, can precipitate such a reaction. This phenomenon is believed to be related to the abundant lymphatic tissue found in the intestine.</description><subject>Animals</subject><subject>Azathioprine - therapeutic use</subject><subject>Body Weight</subject><subject>Dogs</subject><subject>Graft Rejection</subject><subject>Hematocrit</subject><subject>Immunosuppression</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine, Small - transplantation</subject><subject>Leukocyte Count</subject><subject>Prednisone - therapeutic use</subject><subject>Time Factors</subject><subject>Transplantation Immunology</subject><subject>Transplantation, Homologous</subject><subject>Xylose - metabolism</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6Ej1U89G0yUWQxS9Y0IOCt5CmCUTapCap4L83dRePHsLMZOZ9M3kAOEXwCkFUX0MIcclrBC8afMkhZrzke2CJWMNLxBjZB8u_kUNwFONHLhGqyAIsaE44qZbg_SX4ttdDLKwrZBt9GJP1OXVdYYdhcj5O4xh0jL-3JulQaJds0FmQdEzWyb6Qfe9TkC6OvXRJzg7H4MDIPuqTXVyBt_u71_VjuXl-eFrfbkpFaJPKylAMMaKQQYKVqWGbDya6wbxiXUs6VlUtMspQKQ0mBjYNJEZRnNWKGEpW4HzrOwb_OeWFxGCj0n1eRPspCoYIozUiebDaDqrgYwzaiDHYQYZvgaCYgYqZlphpiSbHGajgWXa285_aQXd_oh3B3L_Z9nX-5JfVQURltVO6y4xUEp23_z_wA7eJhjE</recordid><startdate>197203</startdate><enddate>197203</enddate><creator>Ruiz, J.Octavio</creator><creator>Uchida, Hisanori</creator><creator>Schultz, Leonard S.</creator><creator>Lillehei, Richard C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197203</creationdate><title>Problems in absorption and immunosuppression after entire intestinal allotransplantation</title><author>Ruiz, J.Octavio ; Uchida, Hisanori ; Schultz, Leonard S. ; Lillehei, Richard C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4f52021508032cf60bf6023e72948db3d844b1fcf5aaf23f07703fc52357c3f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Animals</topic><topic>Azathioprine - therapeutic use</topic><topic>Body Weight</topic><topic>Dogs</topic><topic>Graft Rejection</topic><topic>Hematocrit</topic><topic>Immunosuppression</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine, Small - transplantation</topic><topic>Leukocyte Count</topic><topic>Prednisone - therapeutic use</topic><topic>Time Factors</topic><topic>Transplantation Immunology</topic><topic>Transplantation, Homologous</topic><topic>Xylose - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz, J.Octavio</creatorcontrib><creatorcontrib>Uchida, Hisanori</creatorcontrib><creatorcontrib>Schultz, Leonard S.</creatorcontrib><creatorcontrib>Lillehei, Richard C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz, J.Octavio</au><au>Uchida, Hisanori</au><au>Schultz, Leonard S.</au><au>Lillehei, Richard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Problems in absorption and immunosuppression after entire intestinal allotransplantation</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1972-03</date><risdate>1972</risdate><volume>123</volume><issue>3</issue><spage>297</spage><epage>303</epage><pages>297-303</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Orthotopic entire small intestine allografts were transplanted in twenty dogs. Ten of these animals received immunosuppressive drugs. Allograft function was compared with that of other dogs subjected to complete intestinal denervation and lymphatic interruption.
Dogs with denervated intestine showed decreased d-xylose absorption with reversal to normal rates within four months. Groups receiving allografts also showed depressed function which persisted for up to five weeks.
Interestingly, dogs with untreated allografts showed no significant pathologic changes even though survival ranged from one to four weeks. In contrast, some dogs who received immunosuppressive drugs showed manifestations of organ rejection. Although we could not clearly demonstrate a graft versus host reaction in untreated allografts, it appears that entire small intestinal allografts, in the absence of these immunosuppressive drugs, can precipitate such a reaction. This phenomenon is believed to be related to the abundant lymphatic tissue found in the intestine.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5011934</pmid><doi>10.1016/0002-9610(72)90289-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 1972-03, Vol.123 (3), p.297-303 |
| issn | 0002-9610 1879-1883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81385613 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Azathioprine - therapeutic use Body Weight Dogs Graft Rejection Hematocrit Immunosuppression Intestinal Absorption Intestinal Mucosa - metabolism Intestine, Small - transplantation Leukocyte Count Prednisone - therapeutic use Time Factors Transplantation Immunology Transplantation, Homologous Xylose - metabolism |
| title | Problems in absorption and immunosuppression after entire intestinal allotransplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A45%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Problems%20in%20absorption%20and%20immunosuppression%20after%20entire%20intestinal%20allotransplantation&rft.jtitle=The%20American%20journal%20of%20surgery&rft.au=Ruiz,%20J.Octavio&rft.date=1972-03&rft.volume=123&rft.issue=3&rft.spage=297&rft.epage=303&rft.pages=297-303&rft.issn=0002-9610&rft.eissn=1879-1883&rft_id=info:doi/10.1016/0002-9610(72)90289-9&rft_dat=%3Cproquest_cross%3E81385613%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81385613&rft_id=info:pmid/5011934&rft_els_id=0002961072902899&rfr_iscdi=true |