Pharmacodynamic application of l-dopa in cardiogenic shock
l-dopa was administered to 20 dogs in cardiogenic shock. Beneficial effects were noted three to five minutes after infusion began, but more significant effects were observed within 15 minutes, reaching a maximum 45 to 60 minutes after infusion. The principal changes observed were: (1) a significant...
Gespeichert in:
| Veröffentlicht in: | The American heart journal 1972-03, Vol.83 (3), p.351-359 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 359 |
|---|---|
| container_issue | 3 |
| container_start_page | 351 |
| container_title | The American heart journal |
| container_volume | 83 |
| creator | Lozano, Jose R. Corday, Eliot Carrasco, Hugo A. Lang, Tzu-Wang Meerbaum, Samuel |
| description | l-dopa was administered to 20 dogs in cardiogenic shock. Beneficial effects were noted three to five minutes after infusion began, but more significant effects were observed within 15 minutes, reaching a maximum 45 to 60 minutes after infusion.
The principal changes observed were: (1) a significant increase in coronary flow, (2) a significant rise in left ventricular
dp
dt
max
, and (3) a decrease in total peripheral vascular resistance. Aortic and mesenteric flows increased significantly. Renal flow did not improve throughout the
l-dopa infusion.
l-dopa benefits were probably due to a stimulation of the beta-receptors. |
| doi_str_mv | 10.1016/0002-8703(72)90436-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81380395</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000287037290436X</els_id><sourcerecordid>81380395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-3951d93193aeb84e3395a241e4ec6ce3a2f22550ebf2ec693e4d2f64546400763</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotVb_gcKeRA-r-c6uB0GKX1DQg0JvIc3O2ujuZk1aof_e1JYePQ0z7zvvMA9CpwRfEUzkNcaY5oXC7ELRyxJzJvPpHhoSXKpcKs730XBnOURHMX6mVtJCDtBAYFEKVQzRzevchNZYX6060zqbmb5vnDUL57vM11mTV743mesya0Ll_Ad0yRTn3n4do4PaNBFOtnWE3h_u38ZP-eTl8Xl8N8ktE2qRs1KQqmSkZAZmBQeWBoZyAhystMAMrSkVAsOspmlSMuAVrSUXXHKMlWQjdL7J7YP_XkJc6NZFC01jOvDLqAvCCpxCk5FvjDb4GAPUug-uNWGlCdZrZHrNQ695aEX1HzI9TWtn2_zlrIVqt7RllPTbjQ7pyR8HQUfroLNQuQB2oSvv_j_wCwInebA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81380395</pqid></control><display><type>article</type><title>Pharmacodynamic application of l-dopa in cardiogenic shock</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lozano, Jose R. ; Corday, Eliot ; Carrasco, Hugo A. ; Lang, Tzu-Wang ; Meerbaum, Samuel</creator><creatorcontrib>Lozano, Jose R. ; Corday, Eliot ; Carrasco, Hugo A. ; Lang, Tzu-Wang ; Meerbaum, Samuel</creatorcontrib><description>l-dopa was administered to 20 dogs in cardiogenic shock. Beneficial effects were noted three to five minutes after infusion began, but more significant effects were observed within 15 minutes, reaching a maximum 45 to 60 minutes after infusion.
The principal changes observed were: (1) a significant increase in coronary flow, (2) a significant rise in left ventricular
dp
dt
max
, and (3) a decrease in total peripheral vascular resistance. Aortic and mesenteric flows increased significantly. Renal flow did not improve throughout the
l-dopa infusion.
l-dopa benefits were probably due to a stimulation of the beta-receptors.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(72)90436-X</identifier><identifier>PMID: 5059578</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Animals ; Aorta ; Blood Pressure - drug effects ; Coronary Circulation - drug effects ; Dihydroxyphenylalanine - pharmacology ; Dihydroxyphenylalanine - therapeutic use ; Disease Models, Animal ; Dogs ; Female ; Heart - drug effects ; Heart Rate - drug effects ; Heart Ventricles ; Kidney - blood supply ; Male ; Mesenteric Arteries ; Mesenteric Veins ; Phenoxybenzamine - pharmacology ; Propranolol - pharmacology ; Regional Blood Flow - drug effects ; Shock, Cardiogenic - drug therapy ; Time Factors ; Vascular Resistance - drug effects</subject><ispartof>The American heart journal, 1972-03, Vol.83 (3), p.351-359</ispartof><rights>1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3951d93193aeb84e3395a241e4ec6ce3a2f22550ebf2ec693e4d2f64546400763</citedby><cites>FETCH-LOGICAL-c357t-3951d93193aeb84e3395a241e4ec6ce3a2f22550ebf2ec693e4d2f64546400763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-8703(72)90436-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5059578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lozano, Jose R.</creatorcontrib><creatorcontrib>Corday, Eliot</creatorcontrib><creatorcontrib>Carrasco, Hugo A.</creatorcontrib><creatorcontrib>Lang, Tzu-Wang</creatorcontrib><creatorcontrib>Meerbaum, Samuel</creatorcontrib><title>Pharmacodynamic application of l-dopa in cardiogenic shock</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>l-dopa was administered to 20 dogs in cardiogenic shock. Beneficial effects were noted three to five minutes after infusion began, but more significant effects were observed within 15 minutes, reaching a maximum 45 to 60 minutes after infusion.
The principal changes observed were: (1) a significant increase in coronary flow, (2) a significant rise in left ventricular
dp
dt
max
, and (3) a decrease in total peripheral vascular resistance. Aortic and mesenteric flows increased significantly. Renal flow did not improve throughout the
l-dopa infusion.
l-dopa benefits were probably due to a stimulation of the beta-receptors.</description><subject>Animals</subject><subject>Aorta</subject><subject>Blood Pressure - drug effects</subject><subject>Coronary Circulation - drug effects</subject><subject>Dihydroxyphenylalanine - pharmacology</subject><subject>Dihydroxyphenylalanine - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Female</subject><subject>Heart - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>Heart Ventricles</subject><subject>Kidney - blood supply</subject><subject>Male</subject><subject>Mesenteric Arteries</subject><subject>Mesenteric Veins</subject><subject>Phenoxybenzamine - pharmacology</subject><subject>Propranolol - pharmacology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Shock, Cardiogenic - drug therapy</subject><subject>Time Factors</subject><subject>Vascular Resistance - drug effects</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcKeRA-r-c6uB0GKX1DQg0JvIc3O2ujuZk1aof_e1JYePQ0z7zvvMA9CpwRfEUzkNcaY5oXC7ELRyxJzJvPpHhoSXKpcKs730XBnOURHMX6mVtJCDtBAYFEKVQzRzevchNZYX6060zqbmb5vnDUL57vM11mTV743mesya0Ll_Ad0yRTn3n4do4PaNBFOtnWE3h_u38ZP-eTl8Xl8N8ktE2qRs1KQqmSkZAZmBQeWBoZyAhystMAMrSkVAsOspmlSMuAVrSUXXHKMlWQjdL7J7YP_XkJc6NZFC01jOvDLqAvCCpxCk5FvjDb4GAPUug-uNWGlCdZrZHrNQ695aEX1HzI9TWtn2_zlrIVqt7RllPTbjQ7pyR8HQUfroLNQuQB2oSvv_j_wCwInebA</recordid><startdate>197203</startdate><enddate>197203</enddate><creator>Lozano, Jose R.</creator><creator>Corday, Eliot</creator><creator>Carrasco, Hugo A.</creator><creator>Lang, Tzu-Wang</creator><creator>Meerbaum, Samuel</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197203</creationdate><title>Pharmacodynamic application of l-dopa in cardiogenic shock</title><author>Lozano, Jose R. ; Corday, Eliot ; Carrasco, Hugo A. ; Lang, Tzu-Wang ; Meerbaum, Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3951d93193aeb84e3395a241e4ec6ce3a2f22550ebf2ec693e4d2f64546400763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Blood Pressure - drug effects</topic><topic>Coronary Circulation - drug effects</topic><topic>Dihydroxyphenylalanine - pharmacology</topic><topic>Dihydroxyphenylalanine - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Female</topic><topic>Heart - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>Heart Ventricles</topic><topic>Kidney - blood supply</topic><topic>Male</topic><topic>Mesenteric Arteries</topic><topic>Mesenteric Veins</topic><topic>Phenoxybenzamine - pharmacology</topic><topic>Propranolol - pharmacology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Shock, Cardiogenic - drug therapy</topic><topic>Time Factors</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lozano, Jose R.</creatorcontrib><creatorcontrib>Corday, Eliot</creatorcontrib><creatorcontrib>Carrasco, Hugo A.</creatorcontrib><creatorcontrib>Lang, Tzu-Wang</creatorcontrib><creatorcontrib>Meerbaum, Samuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lozano, Jose R.</au><au>Corday, Eliot</au><au>Carrasco, Hugo A.</au><au>Lang, Tzu-Wang</au><au>Meerbaum, Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacodynamic application of l-dopa in cardiogenic shock</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1972-03</date><risdate>1972</risdate><volume>83</volume><issue>3</issue><spage>351</spage><epage>359</epage><pages>351-359</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>l-dopa was administered to 20 dogs in cardiogenic shock. Beneficial effects were noted three to five minutes after infusion began, but more significant effects were observed within 15 minutes, reaching a maximum 45 to 60 minutes after infusion.
The principal changes observed were: (1) a significant increase in coronary flow, (2) a significant rise in left ventricular
dp
dt
max
, and (3) a decrease in total peripheral vascular resistance. Aortic and mesenteric flows increased significantly. Renal flow did not improve throughout the
l-dopa infusion.
l-dopa benefits were probably due to a stimulation of the beta-receptors.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>5059578</pmid><doi>10.1016/0002-8703(72)90436-X</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8703 |
| ispartof | The American heart journal, 1972-03, Vol.83 (3), p.351-359 |
| issn | 0002-8703 1097-6744 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81380395 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Aorta Blood Pressure - drug effects Coronary Circulation - drug effects Dihydroxyphenylalanine - pharmacology Dihydroxyphenylalanine - therapeutic use Disease Models, Animal Dogs Female Heart - drug effects Heart Rate - drug effects Heart Ventricles Kidney - blood supply Male Mesenteric Arteries Mesenteric Veins Phenoxybenzamine - pharmacology Propranolol - pharmacology Regional Blood Flow - drug effects Shock, Cardiogenic - drug therapy Time Factors Vascular Resistance - drug effects |
| title | Pharmacodynamic application of l-dopa in cardiogenic shock |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T03%3A28%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacodynamic%20application%20of%20l-dopa%20in%20cardiogenic%20shock&rft.jtitle=The%20American%20heart%20journal&rft.au=Lozano,%20Jose%20R.&rft.date=1972-03&rft.volume=83&rft.issue=3&rft.spage=351&rft.epage=359&rft.pages=351-359&rft.issn=0002-8703&rft.eissn=1097-6744&rft_id=info:doi/10.1016/0002-8703(72)90436-X&rft_dat=%3Cproquest_cross%3E81380395%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81380395&rft_id=info:pmid/5059578&rft_els_id=000287037290436X&rfr_iscdi=true |