Increased sensitivity of rabbit carotid body chemoreceptors to dopamine after chronic treatment with domperidone
An increase in specific dopamine D 2 receptor binding sites was observed in membranes prepared from the carotid bodies of rabbits treated for 8 weeks and then withdrawn for 4–9 days from the D 2 antagonist domperidone (2–5 mg/kg per day). Recordings of chemoreceptor afferent discharge from the carot...
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| Veröffentlicht in: | European journal of pharmacology 1984-09, Vol.104 (1), p.39-46 |
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| container_title | European journal of pharmacology |
| container_volume | 104 |
| creator | Mcqueen, Daniel S. Mir, Anis K. Brash, Harry M. Nahorski, Stefan R. |
| description | An increase in specific dopamine D
2 receptor binding sites was observed in membranes prepared from the carotid bodies of rabbits treated for 8 weeks and then withdrawn for 4–9 days from the D
2 antagonist domperidone (2–5 mg/kg per day). Recordings of chemoreceptor afferent discharge from the carotid body also revealed that this change in receptor density was accompanied by an increased sensitivity to the chemodepressant effects of exogenous dopamine. The chemoreceptor responsiveness of the carotid body to hypoxia is blunted in rabbits treated chronically with domperidone, but this can be restored to normal by an acute dose of the D
2 antagonist. These experiments provide evidence that is compatible with a chemo-inhibitory role for endogenous dopamine in the rabbit's carotid body. Furthermore, these results suggest that the carotid body provides a useful model for the functional studies of dopamine D
2 receptors. |
| doi_str_mv | 10.1016/0014-2999(84)90366-2 |
| format | Article |
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2 receptor binding sites was observed in membranes prepared from the carotid bodies of rabbits treated for 8 weeks and then withdrawn for 4–9 days from the D
2 antagonist domperidone (2–5 mg/kg per day). Recordings of chemoreceptor afferent discharge from the carotid body also revealed that this change in receptor density was accompanied by an increased sensitivity to the chemodepressant effects of exogenous dopamine. The chemoreceptor responsiveness of the carotid body to hypoxia is blunted in rabbits treated chronically with domperidone, but this can be restored to normal by an acute dose of the D
2 antagonist. These experiments provide evidence that is compatible with a chemo-inhibitory role for endogenous dopamine in the rabbit's carotid body. Furthermore, these results suggest that the carotid body provides a useful model for the functional studies of dopamine D
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2 receptor binding sites was observed in membranes prepared from the carotid bodies of rabbits treated for 8 weeks and then withdrawn for 4–9 days from the D
2 antagonist domperidone (2–5 mg/kg per day). Recordings of chemoreceptor afferent discharge from the carotid body also revealed that this change in receptor density was accompanied by an increased sensitivity to the chemodepressant effects of exogenous dopamine. The chemoreceptor responsiveness of the carotid body to hypoxia is blunted in rabbits treated chronically with domperidone, but this can be restored to normal by an acute dose of the D
2 antagonist. These experiments provide evidence that is compatible with a chemo-inhibitory role for endogenous dopamine in the rabbit's carotid body. Furthermore, these results suggest that the carotid body provides a useful model for the functional studies of dopamine D
2 receptors.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Carotid Body - drug effects</subject><subject>Carotid Body - metabolism</subject><subject>Catecholaminergic system</subject><subject>Chemoreceptor Cells - drug effects</subject><subject>Chemoreceptor Cells - metabolism</subject><subject>Domperidone - metabolism</subject><subject>Domperidone - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Dopamine - pharmacology</subject><subject>Electrophysiology</subject><subject>Ergolines - pharmacology</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membranes - drug effects</subject><subject>Neurons - drug effects</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinpirole</subject><subject>Rabbits</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - metabolism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFTEUhYMo9bX1HyhkIaKLsTczmWSyKUixtlBwo-uQSW5o5E0yJnkt798743u8pa4u3Pvdw-EcQt4y-MyAiSsAxptWKfVx4J8UdEI07QuyYYNUDUjWviSbE_KanJfyCwB61fZn5EzwZcnkhsz30WY0BR0tGEuo4SnUPU2eZjOOoVJrcqrB0TG5PbWPOKWMFueacqE1UZdmM4WI1PiKeQFyisHSumjWCWOlz6E-LtQ0Yw4uRbwkr7zZFnxznBfk5-3XHzd3zcP3b_c3Xx4ay5mszYiyR6_M4PwA1vSi77zgaADViEyNig_S96PoOZe-6zk4ixJAGjM6B67tLsiHg-6c0-8dlqqnUCxutyZi2hU9sI6LTnT_BRkHztSgFpAfQJtTKRm9nnOYTN5rBnptRK9x6zVuPXD9txG9Gnl31N-NE7rT07GC5f7-eDfFmq3PJtpQTpiCfuhgtXl9wHAJ7Slg1sUGjBZdWAqp2qXwbx9_AOGaqhg</recordid><startdate>19840903</startdate><enddate>19840903</enddate><creator>Mcqueen, Daniel S.</creator><creator>Mir, Anis K.</creator><creator>Brash, Harry M.</creator><creator>Nahorski, Stefan R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19840903</creationdate><title>Increased sensitivity of rabbit carotid body chemoreceptors to dopamine after chronic treatment with domperidone</title><author>Mcqueen, Daniel S. ; Mir, Anis K. ; Brash, Harry M. ; Nahorski, Stefan R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-be75ef9a8df80ca5653f64ea0e9be19b9487f5b65447f3540dce7007aabdd0d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Carotid Body - drug effects</topic><topic>Carotid Body - metabolism</topic><topic>Catecholaminergic system</topic><topic>Chemoreceptor Cells - drug effects</topic><topic>Chemoreceptor Cells - metabolism</topic><topic>Domperidone - metabolism</topic><topic>Domperidone - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Dopamine - pharmacology</topic><topic>Electrophysiology</topic><topic>Ergolines - pharmacology</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membranes - drug effects</topic><topic>Neurons - drug effects</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinpirole</topic><topic>Rabbits</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mcqueen, Daniel S.</creatorcontrib><creatorcontrib>Mir, Anis K.</creatorcontrib><creatorcontrib>Brash, Harry M.</creatorcontrib><creatorcontrib>Nahorski, Stefan R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mcqueen, Daniel S.</au><au>Mir, Anis K.</au><au>Brash, Harry M.</au><au>Nahorski, Stefan R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased sensitivity of rabbit carotid body chemoreceptors to dopamine after chronic treatment with domperidone</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1984-09-03</date><risdate>1984</risdate><volume>104</volume><issue>1</issue><spage>39</spage><epage>46</epage><pages>39-46</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>An increase in specific dopamine D
2 receptor binding sites was observed in membranes prepared from the carotid bodies of rabbits treated for 8 weeks and then withdrawn for 4–9 days from the D
2 antagonist domperidone (2–5 mg/kg per day). Recordings of chemoreceptor afferent discharge from the carotid body also revealed that this change in receptor density was accompanied by an increased sensitivity to the chemodepressant effects of exogenous dopamine. The chemoreceptor responsiveness of the carotid body to hypoxia is blunted in rabbits treated chronically with domperidone, but this can be restored to normal by an acute dose of the D
2 antagonist. These experiments provide evidence that is compatible with a chemo-inhibitory role for endogenous dopamine in the rabbit's carotid body. Furthermore, these results suggest that the carotid body provides a useful model for the functional studies of dopamine D
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| ispartof | European journal of pharmacology, 1984-09, Vol.104 (1), p.39-46 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Binding Sites Biological and medical sciences Carotid Body - drug effects Carotid Body - metabolism Catecholaminergic system Chemoreceptor Cells - drug effects Chemoreceptor Cells - metabolism Domperidone - metabolism Domperidone - pharmacology Dopamine - metabolism Dopamine - pharmacology Electrophysiology Ergolines - pharmacology Hypoxia - physiopathology Male Medical sciences Membranes - drug effects Neurons - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Quinpirole Rabbits Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism |
| title | Increased sensitivity of rabbit carotid body chemoreceptors to dopamine after chronic treatment with domperidone |
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