Effects of morphine and naloxone on hippocampal CA3 field potentials following systemic administration in the freely-moving rat
The effect of IV morphine, 2, 6 and 15 mg/kg, on hilar-evoked CA3 field potentials was studied to determine if this area would be more sensitive to mu-type opiate agonists than the CA1 or dentate regions. In addition, the effect of IV naloxone, 2 and 25 mg/kg, on the same responses was studied to de...
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| Veröffentlicht in: | Brain research bulletin 1984-01, Vol.13 (2), p.241-245 |
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| creator | Linseman, M.A. Corrigall, W.A. |
| description | The effect of IV morphine, 2, 6 and 15 mg/kg, on hilar-evoked CA3 field potentials was studied to determine if this area would be more sensitive to mu-type opiate agonists than the CA1 or dentate regions. In addition, the effect of IV naloxone, 2 and 25 mg/kg, on the same responses was studied to determine if endogenous opiates reported to be present in the mossy fibers are released by electrical stimulation of this pathway. Neither morphine nor naloxone had an effect on CA3 field potentials at any dose used. The CA1 region of the hippocampus is the area most sensitive to morphine, and this effect of morphine correlates best, anatomically, with the localization of mu-receptors identified by the binding of dihydromorphine. Physiological release of endogenous opiates from the hippocampus remains to be shown. |
| doi_str_mv | 10.1016/0361-9230(84)90123-0 |
| format | Article |
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In addition, the effect of IV naloxone, 2 and 25 mg/kg, on the same responses was studied to determine if endogenous opiates reported to be present in the mossy fibers are released by electrical stimulation of this pathway. Neither morphine nor naloxone had an effect on CA3 field potentials at any dose used. The CA1 region of the hippocampus is the area most sensitive to morphine, and this effect of morphine correlates best, anatomically, with the localization of mu-receptors identified by the binding of dihydromorphine. Physiological release of endogenous opiates from the hippocampus remains to be shown.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(84)90123-0</identifier><identifier>PMID: 6093941</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; CA3 ; Central nervous system ; Electrophysiology ; Endorphins - physiology ; Evoked Potentials - drug effects ; Field potentials ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Male ; Morphine ; Morphine - pharmacology ; Mossy fibers ; Naloxone ; Naloxone - pharmacology ; Opiate ; Rats ; Rats, Inbred Strains ; Receptors, Opioid - physiology ; Receptors, Opioid, mu ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research bulletin, 1984-01, Vol.13 (2), p.241-245</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3b1cc4a038a18140baa3c88d876a919aa22287be1106a89d68c397c0b92d9273</citedby><cites>FETCH-LOGICAL-c417t-3b1cc4a038a18140baa3c88d876a919aa22287be1106a89d68c397c0b92d9273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(84)90123-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8886684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6093941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Linseman, M.A.</creatorcontrib><creatorcontrib>Corrigall, W.A.</creatorcontrib><title>Effects of morphine and naloxone on hippocampal CA3 field potentials following systemic administration in the freely-moving rat</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>The effect of IV morphine, 2, 6 and 15 mg/kg, on hilar-evoked CA3 field potentials was studied to determine if this area would be more sensitive to mu-type opiate agonists than the CA1 or dentate regions. In addition, the effect of IV naloxone, 2 and 25 mg/kg, on the same responses was studied to determine if endogenous opiates reported to be present in the mossy fibers are released by electrical stimulation of this pathway. Neither morphine nor naloxone had an effect on CA3 field potentials at any dose used. The CA1 region of the hippocampus is the area most sensitive to morphine, and this effect of morphine correlates best, anatomically, with the localization of mu-receptors identified by the binding of dihydromorphine. Physiological release of endogenous opiates from the hippocampus remains to be shown.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CA3</subject><subject>Central nervous system</subject><subject>Electrophysiology</subject><subject>Endorphins - physiology</subject><subject>Evoked Potentials - drug effects</subject><subject>Field potentials</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Mossy fibers</subject><subject>Naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Opiate</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Opioid - physiology</subject><subject>Receptors, Opioid, mu</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnRjD2tb6AJC2N0UQoFQ8Fmkkln_EkmcTN7cou6ZWMoKKF6xl756tJ2p5e6InA-zr05h5BXnH3gjKuPTCjemFawd1q-N4y3omFPyIrrTjRtJ7unZHVGnpPLUn4wxpS-UhfkQjEjjOQr8vt2HNEthaaRTinPWx-RQhxohJB-pXpJkW79PCcH0wyBbm4EHT2Ggc5pwbh4CIWOKYT06ON3WvZlwck7CsPkoy9LhsVXCx_pskU6ZsSwb6b0cICr9oI8G6sDvjyda3L_6fZ-86W5-_b56-bmrnGSd0sjeu6cBCY0cM0l6wGE03rQnQLDDUDbtrrrkXOmQJtBaSdM51hv2sG0nViTt0fbOaefOyyLnXxxGAJETLtiNReS6av2v2CdXUcZXkF5BF1OpWQc7Zz9BHlvObOHfuwhfHsI32pp__ZTn9bk9cl_1084nD-dCqn6m5MOxUEYM0TnyxnTWiulZcWujxjWzB48Zlucx-hw8LnWaYfk_73HH4XbrO8</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Linseman, M.A.</creator><creator>Corrigall, W.A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Effects of morphine and naloxone on hippocampal CA3 field potentials following systemic administration in the freely-moving rat</title><author>Linseman, M.A. ; Corrigall, W.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3b1cc4a038a18140baa3c88d876a919aa22287be1106a89d68c397c0b92d9273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CA3</topic><topic>Central nervous system</topic><topic>Electrophysiology</topic><topic>Endorphins - physiology</topic><topic>Evoked Potentials - drug effects</topic><topic>Field potentials</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Mossy fibers</topic><topic>Naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Opiate</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - physiology</topic><topic>Receptors, Opioid, mu</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linseman, M.A.</creatorcontrib><creatorcontrib>Corrigall, W.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linseman, M.A.</au><au>Corrigall, W.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of morphine and naloxone on hippocampal CA3 field potentials following systemic administration in the freely-moving rat</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>13</volume><issue>2</issue><spage>241</spage><epage>245</epage><pages>241-245</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The effect of IV morphine, 2, 6 and 15 mg/kg, on hilar-evoked CA3 field potentials was studied to determine if this area would be more sensitive to mu-type opiate agonists than the CA1 or dentate regions. In addition, the effect of IV naloxone, 2 and 25 mg/kg, on the same responses was studied to determine if endogenous opiates reported to be present in the mossy fibers are released by electrical stimulation of this pathway. Neither morphine nor naloxone had an effect on CA3 field potentials at any dose used. The CA1 region of the hippocampus is the area most sensitive to morphine, and this effect of morphine correlates best, anatomically, with the localization of mu-receptors identified by the binding of dihydromorphine. Physiological release of endogenous opiates from the hippocampus remains to be shown.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6093941</pmid><doi>10.1016/0361-9230(84)90123-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research bulletin, 1984-01, Vol.13 (2), p.241-245 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences CA3 Central nervous system Electrophysiology Endorphins - physiology Evoked Potentials - drug effects Field potentials Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology Male Morphine Morphine - pharmacology Mossy fibers Naloxone Naloxone - pharmacology Opiate Rats Rats, Inbred Strains Receptors, Opioid - physiology Receptors, Opioid, mu Vertebrates: nervous system and sense organs |
| title | Effects of morphine and naloxone on hippocampal CA3 field potentials following systemic administration in the freely-moving rat |
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