Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: Effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis

The functional activity of the sphincter of Oddi complex has been examined by ceruletide manometry in patients undergoing cholecystectomy with a normal peroperative cholangiogram. In Group I (n = 14), which included patients with previous acute cholecystitis/biliary colic, the sphincter activity app...

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Veröffentlicht in:British journal of surgery 1984-11, Vol.71 (11), p.885-888
Hauptverfasser: Cuschieri, A., Cumming, J. G. R., Wood, R. A. B., Baker, P. R.
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container_end_page 888
container_issue 11
container_start_page 885
container_title British journal of surgery
container_volume 71
creator Cuschieri, A.
Cumming, J. G. R.
Wood, R. A. B.
Baker, P. R.
description The functional activity of the sphincter of Oddi complex has been examined by ceruletide manometry in patients undergoing cholecystectomy with a normal peroperative cholangiogram. In Group I (n = 14), which included patients with previous acute cholecystitis/biliary colic, the sphincter activity appeared to be normal and responded to intravenous ceruletide by a marked relaxation with a significant fall in both the infusion and postinfusion pressures. In patients undergoing cholecystectomy for gallstone‐associated pancreatitis (n = 8), the sphincter exhibited manometric features of hypotonia with low infusion and postinfusion pressures which were not significantly altered by intravenous ceruletide.
doi_str_mv 10.1002/bjs.1800711127
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G. R.</creatorcontrib><creatorcontrib>Wood, R. A. B.</creatorcontrib><creatorcontrib>Baker, P. R.</creatorcontrib><title>Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: Effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>The functional activity of the sphincter of Oddi complex has been examined by ceruletide manometry in patients undergoing cholecystectomy with a normal peroperative cholangiogram. In Group I (n = 14), which included patients with previous acute cholecystitis/biliary colic, the sphincter activity appeared to be normal and responded to intravenous ceruletide by a marked relaxation with a significant fall in both the infusion and postinfusion pressures. In patients undergoing cholecystectomy for gallstone‐associated pancreatitis (n = 8), the sphincter exhibited manometric features of hypotonia with low infusion and postinfusion pressures which were not significantly altered by intravenous ceruletide.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Ampulla of Vater - physiopathology</subject><subject>Biliary manometry</subject><subject>Biological and medical sciences</subject><subject>ceruletide</subject><subject>Ceruletide - pharmacology</subject><subject>Cholecystectomy</subject><subject>Cholecystitis - physiopathology</subject><subject>Cholelithiasis - physiopathology</subject><subject>Cholelithiasis - surgery</subject><subject>Colic - physiopathology</subject><subject>Common Bile Duct - physiopathology</subject><subject>gallstone pancreatitis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. 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Exocrine pancreas</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis - physiopathology</topic><topic>Sphincter of Oddi - drug effects</topic><topic>Sphincter of Oddi - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuschieri, A.</creatorcontrib><creatorcontrib>Cumming, J. G. R.</creatorcontrib><creatorcontrib>Wood, R. A. B.</creatorcontrib><creatorcontrib>Baker, P. 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R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: Effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1984-11</date><risdate>1984</risdate><volume>71</volume><issue>11</issue><spage>885</spage><epage>888</epage><pages>885-888</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>The functional activity of the sphincter of Oddi complex has been examined by ceruletide manometry in patients undergoing cholecystectomy with a normal peroperative cholangiogram. In Group I (n = 14), which included patients with previous acute cholecystitis/biliary colic, the sphincter activity appeared to be normal and responded to intravenous ceruletide by a marked relaxation with a significant fall in both the infusion and postinfusion pressures. In patients undergoing cholecystectomy for gallstone‐associated pancreatitis (n = 8), the sphincter exhibited manometric features of hypotonia with low infusion and postinfusion pressures which were not significantly altered by intravenous ceruletide.</abstract><cop>Bristol</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>6498460</pmid><doi>10.1002/bjs.1800711127</doi><tpages>4</tpages></addata></record>
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subjects Acute Disease
Adult
Aged
Ampulla of Vater - physiopathology
Biliary manometry
Biological and medical sciences
ceruletide
Ceruletide - pharmacology
Cholecystectomy
Cholecystitis - physiopathology
Cholelithiasis - physiopathology
Cholelithiasis - surgery
Colic - physiopathology
Common Bile Duct - physiopathology
gallstone pancreatitis
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Manometry
Medical sciences
Middle Aged
Other diseases. Semiology
Pancreatitis - physiopathology
Sphincter of Oddi - drug effects
Sphincter of Oddi - physiopathology
title Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: Effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis
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