The interaction of mitochondrial transhydrogenase with derivatives of coenzyme A

The 2,4‐dinitrophenyl derivative of dephospho‐CoA and the 7‐nitrobenzofurazan‐4‐yl derivative of CoA are competitive inhibitors (Ki 3 μM and 2.6 μM respectively) of mitochondrial transhydrogenase with regard to NAD+ and NADPH respectively. The 7‐nitrobenzofurazan‐4‐yl derivative of dephospho‐CoA is...

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Veröffentlicht in:	European journal of biochemistry 1984-01, Vol.145 (2), p.413-416
Hauptverfasser:	KOZLOV, Igor A., MILGROM, Yakov M., SABUROVA, Larissa A., SOBOLEV, Alexander Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cattle coenzyme A Coenzyme A - analogs & derivatives Coenzyme A - pharmacology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Kinetics mitochondria Mitochondria, Heart - enzymology NAD(P super(+)) transhydrogenase NADH, NADPH Oxidoreductases - metabolism NADP Transhydrogenases - antagonists & inhibitors NADP Transhydrogenases - metabolism Oxidoreductases Structure-Activity Relationship
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