Formation of a stable complex of thrombin and the secreted platelet protein glycoprotein G (thrombin-sensitive protein, thrombospondin) by thiol-disulfide exchange

When 125I-labeled thrombin was incubated with washed human platelets or with the supernatant solution of activated platelets, it formed a NaDodSO4-stable complex of apparent mass greater than 450 000 daltons. Formation of the complex was temperature dependent; with 20 nM thrombin incubated with the...

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Veröffentlicht in:	Biochemistry (Easton) 1984-10, Vol.23 (21), p.4984-4990
Hauptverfasser:	Danishefsky, Kenneth J, Alexander, Richard J, Detwiler, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Calcimycin - pharmacology Coagulation factors Fundamental and applied biological sciences. Psychology glycoprotein A Glycoproteins - metabolism Humans Kinetics Macromolecular Substances man Molecular and cellular biology Molecular Weight Platelet Aggregation - drug effects platelets Thermodynamics thrombin Thrombin - metabolism Thrombospondins
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