Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids
Several reports have shown that the prolactin response to suckling in rats can be blunted by administration of the opiate antagonist naloxone. In order to investigate whether the prolactin response to breast stimulation in women is similarly affected by naloxone, nine healthy lactating women partici...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1984-11, Vol.150 (5), p.558-561 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Cholst, Ina N. Wardlaw, Sharon L. Newman, Connie B. Frantz, Andrew G. |
| description | Several reports have shown that the prolactin response to suckling in rats can be blunted by administration of the opiate antagonist naloxone. In order to investigate whether the prolactin response to breast stimulation in women is similarly affected by naloxone, nine healthy lactating women participated in 10 studies. Each woman served as her own control and was studied on two occasions, receiving pretreatment with either saline solution or naloxone. Prolactin was measured in the baseline state and for 60 minutes after the onset of a 20-minute period of nipple stimulation by use of the Egnell mechanical breast pump. Neither baseline nor stimulated prolactin values were different by paired t test. Thus, in contrast to rats, an opioid pathway does not appear to be involved in the prolactin response to suckling in humans. |
| doi_str_mv | 10.1016/S0002-9378(84)90439-3 |
| format | Article |
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Thus, in contrast to rats, an opioid pathway does not appear to be involved in the prolactin response to suckling in humans.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(84)90439-3</identifier><identifier>PMID: 6496587</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Breast Feeding ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; Lactation ; Naloxone - pharmacology ; Nipples ; Physical Stimulation ; Pregnancy ; Pregnancy. Parturition. 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In order to investigate whether the prolactin response to breast stimulation in women is similarly affected by naloxone, nine healthy lactating women participated in 10 studies. Each woman served as her own control and was studied on two occasions, receiving pretreatment with either saline solution or naloxone. Prolactin was measured in the baseline state and for 60 minutes after the onset of a 20-minute period of nipple stimulation by use of the Egnell mechanical breast pump. Neither baseline nor stimulated prolactin values were different by paired t test. Thus, in contrast to rats, an opioid pathway does not appear to be involved in the prolactin response to suckling in humans.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Lactation</subject><subject>Naloxone - pharmacology</subject><subject>Nipples</subject><subject>Physical Stimulation</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Prolactin - blood</subject><subject>Prolactin - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rVDEUhoNY6lj9CYUsROriar5ubrISKfUDChXUdcjHuSVybzImGaX_3kxnmG1X4eQ8Jzk8L0KXlLynhMoPPwghbNB8UldKvNNEcD3wZ2hDiZ4GqaR6jjYn5AV6Wevvfck0O0fnUmg5qmmD7PeSF-tbTLhA3eZUAbeMXQFbG64trrvFtpgT7sQe7EW6x__yCv2q4pQbXiFE2yBg94AhhXwPKe8qztuYY6iv0Nlslwqvj-cF-vX55uf11-H27su360-3gxeMtMFRoXVgMwEX5Dx7ZjmdhJ-9tp5aGEctnJVcCTcSq2mQjnnubbDcz8GNgV-gt4d3tyX_2UFtZo3Vw7LYBH0doyhnSgn1JEiFGLmQtIPjAfQl11pgNtsSV1seDCVmn4F5zMDsBRslzGMGhve5y-MHO9fdnKaO0nv_zbFvq7fLXGzysZ4wTdnEmezYxwMG3drfCMVUHyH5bruAbybk-MQi_wGQJKW-</recordid><startdate>19841101</startdate><enddate>19841101</enddate><creator>Cholst, Ina N.</creator><creator>Wardlaw, Sharon L.</creator><creator>Newman, Connie B.</creator><creator>Frantz, Andrew G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SQ</scope><scope>7X8</scope></search><sort><creationdate>19841101</creationdate><title>Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids</title><author>Cholst, Ina N. ; Wardlaw, Sharon L. ; Newman, Connie B. ; Frantz, Andrew G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-b1499d2f0ebd6ffc2a3174cfc9ac1ae5594ba6384b50a91d6b2c3cada3cfdb5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Lactation</topic><topic>Naloxone - pharmacology</topic><topic>Nipples</topic><topic>Physical Stimulation</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Prolactin - blood</topic><topic>Prolactin - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cholst, Ina N.</creatorcontrib><creatorcontrib>Wardlaw, Sharon L.</creatorcontrib><creatorcontrib>Newman, Connie B.</creatorcontrib><creatorcontrib>Frantz, Andrew G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Endocrinology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cholst, Ina N.</au><au>Wardlaw, Sharon L.</au><au>Newman, Connie B.</au><au>Frantz, Andrew G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1984-11-01</date><risdate>1984</risdate><volume>150</volume><issue>5</issue><spage>558</spage><epage>561</epage><pages>558-561</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Several reports have shown that the prolactin response to suckling in rats can be blunted by administration of the opiate antagonist naloxone. In order to investigate whether the prolactin response to breast stimulation in women is similarly affected by naloxone, nine healthy lactating women participated in 10 studies. Each woman served as her own control and was studied on two occasions, receiving pretreatment with either saline solution or naloxone. Prolactin was measured in the baseline state and for 60 minutes after the onset of a 20-minute period of nipple stimulation by use of the Egnell mechanical breast pump. Neither baseline nor stimulated prolactin values were different by paired t test. Thus, in contrast to rats, an opioid pathway does not appear to be involved in the prolactin response to suckling in humans.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>6496587</pmid><doi>10.1016/S0002-9378(84)90439-3</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1984-11, Vol.150 (5), p.558-561 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Biological and medical sciences Breast Feeding Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Lactation Naloxone - pharmacology Nipples Physical Stimulation Pregnancy Pregnancy. Parturition. Lactation Prolactin - blood Prolactin - metabolism Vertebrates: reproduction |
| title | Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids |
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