The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone
KIMURA, I. and AYYAR, D.R. The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone. Tohoku J. exp. Med., 1984, 143 (4), 405-408 - A 34-year-old women with the Eaton-Lambert myasthenic syndrome was treated with prednisolone for over a year. Proximal muscle weakness and breathi...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1984, Vol.143(4), pp.405-408 |
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| container_title | The Tohoku Journal of Experimental Medicine |
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| creator | KIMURA, ITARU AYYAR, D.R. |
| description | KIMURA, I. and AYYAR, D.R. The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone. Tohoku J. exp. Med., 1984, 143 (4), 405-408 - A 34-year-old women with the Eaton-Lambert myasthenic syndrome was treated with prednisolone for over a year. Proximal muscle weakness and breathing difficulty due to weakness in the respiratory muscles showed improvements after long-term administration of prednisolone. Electrophysiological studies before treatment revealed decreased amplitudes of the compound muscle action potential (CMAP), a decrement in CMAP to low frequency nerve stimulation, an increment on high frequency stimulation and posttetanic facilitation over 300%. Following administration of prednisolone, these electrophysiological parameters became almost normal. This case suggests that immunosuppressive drugs such as prednisolone may have a place in the management of the patients with myasthenic syndrome, especially of those who has no evidence of malignant tumor. |
| doi_str_mv | 10.1620/tjem.143.405 |
| format | Article |
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The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone. Tohoku J. exp. Med., 1984, 143 (4), 405-408 - A 34-year-old women with the Eaton-Lambert myasthenic syndrome was treated with prednisolone for over a year. Proximal muscle weakness and breathing difficulty due to weakness in the respiratory muscles showed improvements after long-term administration of prednisolone. Electrophysiological studies before treatment revealed decreased amplitudes of the compound muscle action potential (CMAP), a decrement in CMAP to low frequency nerve stimulation, an increment on high frequency stimulation and posttetanic facilitation over 300%. Following administration of prednisolone, these electrophysiological parameters became almost normal. This case suggests that immunosuppressive drugs such as prednisolone may have a place in the management of the patients with myasthenic syndrome, especially of those who has no evidence of malignant tumor.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.143.405</identifier><identifier>PMID: 6495320</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Action Potentials ; Adult ; Eaton-Lambert syndrome ; electrodiagnosis ; Electrophysiology ; Female ; Humans ; Muscles - physiopathology ; myasthenic syndrome ; Neuromuscular Diseases - drug therapy ; neuromuscular transmission ; Prednisolone - administration & dosage ; Prednisolone - therapeutic use ; Syndrome ; Time Factors</subject><ispartof>The Tohoku Journal of Experimental Medicine, 1984, Vol.143(4), pp.405-408</ispartof><rights>Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-1b42e77099a017fb4a479e3ae030a5bd0ca58a8c97835d2794ca30e82c054e423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6495320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMURA, ITARU</creatorcontrib><creatorcontrib>AYYAR, D.R.</creatorcontrib><title>The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>KIMURA, I. and AYYAR, D.R. The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone. Tohoku J. exp. Med., 1984, 143 (4), 405-408 - A 34-year-old women with the Eaton-Lambert myasthenic syndrome was treated with prednisolone for over a year. Proximal muscle weakness and breathing difficulty due to weakness in the respiratory muscles showed improvements after long-term administration of prednisolone. Electrophysiological studies before treatment revealed decreased amplitudes of the compound muscle action potential (CMAP), a decrement in CMAP to low frequency nerve stimulation, an increment on high frequency stimulation and posttetanic facilitation over 300%. Following administration of prednisolone, these electrophysiological parameters became almost normal. This case suggests that immunosuppressive drugs such as prednisolone may have a place in the management of the patients with myasthenic syndrome, especially of those who has no evidence of malignant tumor.</description><subject>Action Potentials</subject><subject>Adult</subject><subject>Eaton-Lambert syndrome</subject><subject>electrodiagnosis</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Humans</subject><subject>Muscles - physiopathology</subject><subject>myasthenic syndrome</subject><subject>Neuromuscular Diseases - drug therapy</subject><subject>neuromuscular transmission</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - therapeutic use</subject><subject>Syndrome</subject><subject>Time Factors</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURi0EgvLYWJEyMZFy_UgdjwiVh1QEEmW2bpxbmipxwHaF-u8JtOpy7_AdneEwdslhzCcCbtOKujFXcqygOGAjLpXJpRTmkI0AFOSlFvqEnca4ApAK9OSYHU-UKaSAEXudLymbYup9PsOuopCylw3GtCTfuOx94-vQd5Shr7NZ7z_zOYUumwfC1JFP2U-TltlboNo3sW97T-fsaIFtpIvdP2MfD9P5_VM-e318vr-b5U4VMuW8UoK0BmMQuF5UCpU2JJFAAhZVDQ6LEktndCmLWmijHEqgUjgoFCkhz9j11vsV-u81xWS7JjpqW_TUr6MtuRTlpDQDeLMFXehjDLSwX6HpMGwsB_vXz_71s0M_O_Qb8Kudd111VO_hXbBhf9juq5jwk_Y7htS4lv5l3AzWf-HuDuI94JYYLHn5Cy2yhAY</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>KIMURA, ITARU</creator><creator>AYYAR, D.R.</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone</title><author>KIMURA, ITARU ; AYYAR, D.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-1b42e77099a017fb4a479e3ae030a5bd0ca58a8c97835d2794ca30e82c054e423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Action Potentials</topic><topic>Adult</topic><topic>Eaton-Lambert syndrome</topic><topic>electrodiagnosis</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Humans</topic><topic>Muscles - physiopathology</topic><topic>myasthenic syndrome</topic><topic>Neuromuscular Diseases - drug therapy</topic><topic>neuromuscular transmission</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - therapeutic use</topic><topic>Syndrome</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIMURA, ITARU</creatorcontrib><creatorcontrib>AYYAR, D.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIMURA, ITARU</au><au>AYYAR, D.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>143</volume><issue>4</issue><spage>405</spage><epage>408</epage><pages>405-408</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>KIMURA, I. and AYYAR, D.R. The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone. Tohoku J. exp. Med., 1984, 143 (4), 405-408 - A 34-year-old women with the Eaton-Lambert myasthenic syndrome was treated with prednisolone for over a year. Proximal muscle weakness and breathing difficulty due to weakness in the respiratory muscles showed improvements after long-term administration of prednisolone. Electrophysiological studies before treatment revealed decreased amplitudes of the compound muscle action potential (CMAP), a decrement in CMAP to low frequency nerve stimulation, an increment on high frequency stimulation and posttetanic facilitation over 300%. Following administration of prednisolone, these electrophysiological parameters became almost normal. This case suggests that immunosuppressive drugs such as prednisolone may have a place in the management of the patients with myasthenic syndrome, especially of those who has no evidence of malignant tumor.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>6495320</pmid><doi>10.1620/tjem.143.405</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | Action Potentials Adult Eaton-Lambert syndrome electrodiagnosis Electrophysiology Female Humans Muscles - physiopathology myasthenic syndrome Neuromuscular Diseases - drug therapy neuromuscular transmission Prednisolone - administration & dosage Prednisolone - therapeutic use Syndrome Time Factors |
| title | The Eaton-Lambert Myasthenic Syndrome and Long-Term Treatment with Prednisolone |
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