ERV3, A full-length human endogenous provirus: Chromosomal localization and evolutionary relationships

A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous chimpanzee provirus, CH2. DNA sequencing within the clone and compariso...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1984-10, Vol.138 (2), p.225-235
Hauptverfasser: O'Connell, Catherine, O'Brien, Stephen, Nash, William G., Cohen, Maurice
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container_issue 2
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container_title Virology (New York, N.Y.)
container_volume 138
creator O'Connell, Catherine
O'Brien, Stephen
Nash, William G.
Cohen, Maurice
description A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous chimpanzee provirus, CH2. DNA sequencing within the clone and comparisons with other retroviruses revealed that ERV3 contains gag and pol gene sequences that are significantly related to those of mammalian type C retroviruses and previously described human endogenous proviruses. The ERV3 genome was determined to reside at a single locus on human chromosome 7 using a panel of rodent X human somatic cell hybrids.
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source MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Amino Acid Sequence
Base Sequence
Biological and medical sciences
Biological Evolution
Chromosome Mapping
Fundamental and applied biological sciences. Psychology
Genes
Genes, Viral
Humans
Microbiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Retroviridae - genetics
Species Specificity
Viral Proteins - genetics
Virology
title ERV3, A full-length human endogenous provirus: Chromosomal localization and evolutionary relationships
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