Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

From an acute B-cell leukemia cell line, a DNA probe was obtained that was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosome 14. This probe detected rearrangement of the homologous DNA segment in the leukemic cells and in foll...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1984-11, Vol.226 (4678), p.1097-1099
Hauptverfasser:	Tsujimoto, Yoshihide, Finger, Lawrence R., Yunis, Jorge, Nowell, Peter C., Croce, Carlo M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B cell leukemia B cell lymphoma B lymphocytes B-Lymphocytes - cytology Biological and medical sciences Cancer Cancer research Cell lines Chromosome Banding Chromosome translocation Chromosomes Chromosomes, Human, 13-15 Chromosomes, Human, 16-18 Cloning Cloning, Molecular Cricetinae Cricetulus DNA probes DNA Restriction Enzymes DNA, Recombinant - analysis Genetic loci Genetic research Germ cells Hematologic and hematopoietic diseases Human chromosomes Humans Hybrid Cells - cytology Karyotyping Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Oncology, Experimental Translocation (Genetics) Translocation, Genetic Translocations (Genetics)
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