Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest
IT is well established that at least two independent loci control the structure of human haemoglobin A 1,2 . Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one 3 or two 4,5 loci. We now describe g...
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| Veröffentlicht in: | Nature (London) 1972-01, Vol.235 (5332), p.47-50 |
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| container_title | Nature (London) |
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| creator | HOLLÁN, S. R SZELENYI, J. G BRIMHALL, B DUERST, M JONES, R. T KOLER, R. D STOCKLEN, Z |
| description | IT is well established that at least two independent loci control the structure of human haemoglobin A
1,2
. Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one
3
or two
4,5
loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain. |
| doi_str_mv | 10.1038/235047a0 |
| format | Article |
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1,2
. Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one
3
or two
4,5
loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/235047a0</identifier><identifier>PMID: 4550395</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alleles ; Blood Protein Electrophoresis ; Chromatography, DEAE-Cellulose ; Chromosome Mapping ; Electrophoresis ; Female ; Genes ; Genotype ; Hemoglobinopathies - genetics ; Hemoglobins, Abnormal - analysis ; Humanities and Social Sciences ; Humans ; letter ; Male ; Middle Aged ; multidisciplinary ; Pedigree ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1972-01, Vol.235 (5332), p.47-50</ispartof><rights>Springer Nature Limited 1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2500-601134f91cc132245ef45e552a76fce2335e158c03491c2144d1fd53f1ab91a3</citedby><cites>FETCH-LOGICAL-c2500-601134f91cc132245ef45e552a76fce2335e158c03491c2144d1fd53f1ab91a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/235047a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/235047a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4550395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOLLÁN, S. R</creatorcontrib><creatorcontrib>SZELENYI, J. G</creatorcontrib><creatorcontrib>BRIMHALL, B</creatorcontrib><creatorcontrib>DUERST, M</creatorcontrib><creatorcontrib>JONES, R. T</creatorcontrib><creatorcontrib>KOLER, R. D</creatorcontrib><creatorcontrib>STOCKLEN, Z</creatorcontrib><title>Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IT is well established that at least two independent loci control the structure of human haemoglobin A
1,2
. Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one
3
or two
4,5
loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain.</description><subject>Alleles</subject><subject>Blood Protein Electrophoresis</subject><subject>Chromatography, DEAE-Cellulose</subject><subject>Chromosome Mapping</subject><subject>Electrophoresis</subject><subject>Female</subject><subject>Genes</subject><subject>Genotype</subject><subject>Hemoglobinopathies - genetics</subject><subject>Hemoglobins, Abnormal - analysis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Pedigree</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkL1OwzAURi0EKqUg8QIgTwiGgH8Tl61U0BQVwdA9chy7TZU4xa4H3h5XKZ0YrCvrOzpX9wPgGqNHjKh4IpQjlkl0AoaYZWnCUpGdgiFCRCRI0PQcXHi_QQhxnLEBGDDOER3zIZh_hGZXbxsNJ812LeF0LWsLF52qoekczEMrLcylbrtV05W19c8wL-F78hIqCaWt9r9Z8qX97hKcGdl4fXWYI7B8e11O82TxOZtPJ4tEEY5QkiKMKTNjrBSmhDCuTXycE5mlRmlCKdeYC4UoiwzBjFXYVJwaLMsxlnQE7nrt1nXfIe4t2tor3TTS6i74QmCKUyFEBO97ULnOe6dNsXV1K91PgVGxL634Ky2iNwdnKFtdHcFDSzF_6HMfE7vSrth0wdl45X-u2561checPrqOwC-WhHn6</recordid><startdate>19720107</startdate><enddate>19720107</enddate><creator>HOLLÁN, S. R</creator><creator>SZELENYI, J. G</creator><creator>BRIMHALL, B</creator><creator>DUERST, M</creator><creator>JONES, R. T</creator><creator>KOLER, R. D</creator><creator>STOCKLEN, Z</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19720107</creationdate><title>Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest</title><author>HOLLÁN, S. R ; SZELENYI, J. G ; BRIMHALL, B ; DUERST, M ; JONES, R. T ; KOLER, R. D ; STOCKLEN, Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2500-601134f91cc132245ef45e552a76fce2335e158c03491c2144d1fd53f1ab91a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Alleles</topic><topic>Blood Protein Electrophoresis</topic><topic>Chromatography, DEAE-Cellulose</topic><topic>Chromosome Mapping</topic><topic>Electrophoresis</topic><topic>Female</topic><topic>Genes</topic><topic>Genotype</topic><topic>Hemoglobinopathies - genetics</topic><topic>Hemoglobins, Abnormal - analysis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Pedigree</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOLLÁN, S. R</creatorcontrib><creatorcontrib>SZELENYI, J. G</creatorcontrib><creatorcontrib>BRIMHALL, B</creatorcontrib><creatorcontrib>DUERST, M</creatorcontrib><creatorcontrib>JONES, R. T</creatorcontrib><creatorcontrib>KOLER, R. D</creatorcontrib><creatorcontrib>STOCKLEN, Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOLLÁN, S. R</au><au>SZELENYI, J. G</au><au>BRIMHALL, B</au><au>DUERST, M</au><au>JONES, R. T</au><au>KOLER, R. D</au><au>STOCKLEN, Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1972-01-07</date><risdate>1972</risdate><volume>235</volume><issue>5332</issue><spage>47</spage><epage>50</epage><pages>47-50</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>IT is well established that at least two independent loci control the structure of human haemoglobin A
1,2
. Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one
3
or two
4,5
loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4550395</pmid><doi>10.1038/235047a0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Nature (London), 1972-01, Vol.235 (5332), p.47-50 |
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| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Alleles Blood Protein Electrophoresis Chromatography, DEAE-Cellulose Chromosome Mapping Electrophoresis Female Genes Genotype Hemoglobinopathies - genetics Hemoglobins, Abnormal - analysis Humanities and Social Sciences Humans letter Male Middle Aged multidisciplinary Pedigree Science Science (multidisciplinary) |
| title | Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest |
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