Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response
Plasma fibronectin, which is an α2-glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorder...
Gespeichert in:
| Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 1984-09, Vol.8 (5), p.493-496 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 496 |
|---|---|
| container_issue | 5 |
| container_start_page | 493 |
| container_title | JPEN. Journal of parenteral and enteral nutrition |
| container_volume | 8 |
| creator | Sandstedt, Stefan Cederblad, Gitten Larsson, Jörgen Schildt, Bo Symreng, Tommy |
| description | Plasma fibronectin, which is an α2-glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorders were studied over a 2-wk period of total parenteral nutrition (TPN). According to nutritional assessment on admission the patients were divided into well nourished (n = 6) and malnourished (n = 12). For comparison nine patients with anorexia nervosa were also studied over a 3-wk period of TPN. Before and after TPN fibronectin, albumin, prealbumin, transferrin, and two acute-phase reactants, haptoglobin and orosomucoid were measured in plasma. The majority of the malnourished patients had an inflammatory reaction in contrast to only a few of the well-nourished and anorexia nervosa patients. Of the proteins measured, only fibronectin rose significantly in the malnourished patients (malnourished and anorexia nervosa), but not in the well nourished patients during TPN. Our results may indicate the usefulness of fibronectin as an indicator of short-term TPN in malnourished subjects, irrespective of the presence or absence of inflammatory response. (Journal of Parenteral and Enteral Nutrition 8:000-000, 1984) |
| doi_str_mv | 10.1177/0148607184008005493 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81316065</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0148607184008005493</sage_id><sourcerecordid>81316065</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4203-e05bafb601d156714946fc1f682227ae4a7ff48a9152eeebe5ef9466678ec3b03</originalsourceid><addsrcrecordid>eNqNkdFrFDEQxoMo9Vr9C0TIg_i2OtnNZrOPUlptqfXQ-rxkcxObI5ucSZZy4B9vzj36JCIMTOD7fTPDF0JeMXjHWNe9B8algI5JDiABWt43T8iK9ZxVNef8KVkdiOqAPCenKW0BoBEAJ-RE1CCbHlbk15U3bkavkQZD70JWjq5VRJ8xluftnKPNNnhaau1UmhS9tGMMHnW2npb6rJwPc7TpHjf02zxui5Log833NMQ_PcyZHtaoaVI5xD39imkXfMIX5JlRLuHLYz8j3y8v7s4_VTdfPl6df7ipNK-hqRDaUZlRANuwVnSM91wYzYyQdV13CrnqjOFS9aytEXHEFk1BhOgk6maE5oy8XebuYvg5Y8rDZJNG55THMKdBsoYJEG0BmwXUMaQU0Qy7aCcV9wOD4ZD58JfMi-v1cfw8Trh59BxDLvqbo66SVs5E5bVNj5iUnWzbvmD9gj1Yh_v_2Txcry9uYTkBFm9SP3DYlv_wJdB_Xv0bGFaofg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81316065</pqid></control><display><type>article</type><title>Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Sandstedt, Stefan ; Cederblad, Gitten ; Larsson, Jörgen ; Schildt, Bo ; Symreng, Tommy</creator><creatorcontrib>Sandstedt, Stefan ; Cederblad, Gitten ; Larsson, Jörgen ; Schildt, Bo ; Symreng, Tommy</creatorcontrib><description>Plasma fibronectin, which is an α2-glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorders were studied over a 2-wk period of total parenteral nutrition (TPN). According to nutritional assessment on admission the patients were divided into well nourished (n = 6) and malnourished (n = 12). For comparison nine patients with anorexia nervosa were also studied over a 3-wk period of TPN. Before and after TPN fibronectin, albumin, prealbumin, transferrin, and two acute-phase reactants, haptoglobin and orosomucoid were measured in plasma. The majority of the malnourished patients had an inflammatory reaction in contrast to only a few of the well-nourished and anorexia nervosa patients. Of the proteins measured, only fibronectin rose significantly in the malnourished patients (malnourished and anorexia nervosa), but not in the well nourished patients during TPN. Our results may indicate the usefulness of fibronectin as an indicator of short-term TPN in malnourished subjects, irrespective of the presence or absence of inflammatory response. (Journal of Parenteral and Enteral Nutrition 8:000-000, 1984)</description><identifier>ISSN: 0148-6071</identifier><identifier>EISSN: 1941-2444</identifier><identifier>DOI: 10.1177/0148607184008005493</identifier><identifier>PMID: 6208390</identifier><identifier>CODEN: JPENDU</identifier><language>eng</language><publisher>Thousand Oaks, CA: Sage Publications</publisher><subject>Adolescent ; Adult ; Aged ; Alpha-Globulins - analysis ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anorexia Nervosa - therapy ; Biological and medical sciences ; Blood Proteins - analysis ; Crohn Disease - complications ; Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; Evaluation Studies as Topic ; Female ; Fibronectins - blood ; Gastrointestinal Neoplasms - complications ; Humans ; Inflammation - blood ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Nutrition Disorders - blood ; Nutrition Disorders - etiology ; Nutrition Disorders - therapy ; Parenteral Nutrition ; Parenteral Nutrition, Total ; Random Allocation</subject><ispartof>JPEN. Journal of parenteral and enteral nutrition, 1984-09, Vol.8 (5), p.493-496</ispartof><rights>1984 by The American Society for Parenteral and Enteral Nutrition</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4203-e05bafb601d156714946fc1f682227ae4a7ff48a9152eeebe5ef9466678ec3b03</citedby><cites>FETCH-LOGICAL-c4203-e05bafb601d156714946fc1f682227ae4a7ff48a9152eeebe5ef9466678ec3b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F0148607184008005493$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F0148607184008005493$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8878559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6208390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandstedt, Stefan</creatorcontrib><creatorcontrib>Cederblad, Gitten</creatorcontrib><creatorcontrib>Larsson, Jörgen</creatorcontrib><creatorcontrib>Schildt, Bo</creatorcontrib><creatorcontrib>Symreng, Tommy</creatorcontrib><title>Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response</title><title>JPEN. Journal of parenteral and enteral nutrition</title><addtitle>JPEN J Parenter Enteral Nutr</addtitle><description>Plasma fibronectin, which is an α2-glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorders were studied over a 2-wk period of total parenteral nutrition (TPN). According to nutritional assessment on admission the patients were divided into well nourished (n = 6) and malnourished (n = 12). For comparison nine patients with anorexia nervosa were also studied over a 3-wk period of TPN. Before and after TPN fibronectin, albumin, prealbumin, transferrin, and two acute-phase reactants, haptoglobin and orosomucoid were measured in plasma. The majority of the malnourished patients had an inflammatory reaction in contrast to only a few of the well-nourished and anorexia nervosa patients. Of the proteins measured, only fibronectin rose significantly in the malnourished patients (malnourished and anorexia nervosa), but not in the well nourished patients during TPN. Our results may indicate the usefulness of fibronectin as an indicator of short-term TPN in malnourished subjects, irrespective of the presence or absence of inflammatory response. (Journal of Parenteral and Enteral Nutrition 8:000-000, 1984)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alpha-Globulins - analysis</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anorexia Nervosa - therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - analysis</subject><subject>Crohn Disease - complications</subject><subject>Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Fibronectins - blood</subject><subject>Gastrointestinal Neoplasms - complications</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nutrition Disorders - blood</subject><subject>Nutrition Disorders - etiology</subject><subject>Nutrition Disorders - therapy</subject><subject>Parenteral Nutrition</subject><subject>Parenteral Nutrition, Total</subject><subject>Random Allocation</subject><issn>0148-6071</issn><issn>1941-2444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdFrFDEQxoMo9Vr9C0TIg_i2OtnNZrOPUlptqfXQ-rxkcxObI5ucSZZy4B9vzj36JCIMTOD7fTPDF0JeMXjHWNe9B8algI5JDiABWt43T8iK9ZxVNef8KVkdiOqAPCenKW0BoBEAJ-RE1CCbHlbk15U3bkavkQZD70JWjq5VRJ8xluftnKPNNnhaau1UmhS9tGMMHnW2npb6rJwPc7TpHjf02zxui5Log833NMQ_PcyZHtaoaVI5xD39imkXfMIX5JlRLuHLYz8j3y8v7s4_VTdfPl6df7ipNK-hqRDaUZlRANuwVnSM91wYzYyQdV13CrnqjOFS9aytEXHEFk1BhOgk6maE5oy8XebuYvg5Y8rDZJNG55THMKdBsoYJEG0BmwXUMaQU0Qy7aCcV9wOD4ZD58JfMi-v1cfw8Trh59BxDLvqbo66SVs5E5bVNj5iUnWzbvmD9gj1Yh_v_2Txcry9uYTkBFm9SP3DYlv_wJdB_Xv0bGFaofg</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Sandstedt, Stefan</creator><creator>Cederblad, Gitten</creator><creator>Larsson, Jörgen</creator><creator>Schildt, Bo</creator><creator>Symreng, Tommy</creator><general>Sage Publications</general><general>SAGE Publications</general><general>ASPEN</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198409</creationdate><title>Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response</title><author>Sandstedt, Stefan ; Cederblad, Gitten ; Larsson, Jörgen ; Schildt, Bo ; Symreng, Tommy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4203-e05bafb601d156714946fc1f682227ae4a7ff48a9152eeebe5ef9466678ec3b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alpha-Globulins - analysis</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anorexia Nervosa - therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - analysis</topic><topic>Crohn Disease - complications</topic><topic>Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Fibronectins - blood</topic><topic>Gastrointestinal Neoplasms - complications</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nutrition Disorders - blood</topic><topic>Nutrition Disorders - etiology</topic><topic>Nutrition Disorders - therapy</topic><topic>Parenteral Nutrition</topic><topic>Parenteral Nutrition, Total</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandstedt, Stefan</creatorcontrib><creatorcontrib>Cederblad, Gitten</creatorcontrib><creatorcontrib>Larsson, Jörgen</creatorcontrib><creatorcontrib>Schildt, Bo</creatorcontrib><creatorcontrib>Symreng, Tommy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandstedt, Stefan</au><au>Cederblad, Gitten</au><au>Larsson, Jörgen</au><au>Schildt, Bo</au><au>Symreng, Tommy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response</atitle><jtitle>JPEN. Journal of parenteral and enteral nutrition</jtitle><addtitle>JPEN J Parenter Enteral Nutr</addtitle><date>1984-09</date><risdate>1984</risdate><volume>8</volume><issue>5</issue><spage>493</spage><epage>496</epage><pages>493-496</pages><issn>0148-6071</issn><eissn>1941-2444</eissn><coden>JPENDU</coden><abstract>Plasma fibronectin, which is an α2-glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorders were studied over a 2-wk period of total parenteral nutrition (TPN). According to nutritional assessment on admission the patients were divided into well nourished (n = 6) and malnourished (n = 12). For comparison nine patients with anorexia nervosa were also studied over a 3-wk period of TPN. Before and after TPN fibronectin, albumin, prealbumin, transferrin, and two acute-phase reactants, haptoglobin and orosomucoid were measured in plasma. The majority of the malnourished patients had an inflammatory reaction in contrast to only a few of the well-nourished and anorexia nervosa patients. Of the proteins measured, only fibronectin rose significantly in the malnourished patients (malnourished and anorexia nervosa), but not in the well nourished patients during TPN. Our results may indicate the usefulness of fibronectin as an indicator of short-term TPN in malnourished subjects, irrespective of the presence or absence of inflammatory response. (Journal of Parenteral and Enteral Nutrition 8:000-000, 1984)</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>6208390</pmid><doi>10.1177/0148607184008005493</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-6071 |
| ispartof | JPEN. Journal of parenteral and enteral nutrition, 1984-09, Vol.8 (5), p.493-496 |
| issn | 0148-6071 1941-2444 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81316065 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Alpha-Globulins - analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anorexia Nervosa - therapy Biological and medical sciences Blood Proteins - analysis Crohn Disease - complications Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Evaluation Studies as Topic Female Fibronectins - blood Gastrointestinal Neoplasms - complications Humans Inflammation - blood Intensive care medicine Male Medical sciences Middle Aged Nutrition Disorders - blood Nutrition Disorders - etiology Nutrition Disorders - therapy Parenteral Nutrition Parenteral Nutrition, Total Random Allocation |
| title | Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T14%3A11%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Total%20Parenteral%20Nutrition%20on%20Plasma%20Fibronectin%20in%20Malnourished%20Subjects%20with%20or%20without%20Inflammatory%20Response&rft.jtitle=JPEN.%20Journal%20of%20parenteral%20and%20enteral%20nutrition&rft.au=Sandstedt,%20Stefan&rft.date=1984-09&rft.volume=8&rft.issue=5&rft.spage=493&rft.epage=496&rft.pages=493-496&rft.issn=0148-6071&rft.eissn=1941-2444&rft.coden=JPENDU&rft_id=info:doi/10.1177/0148607184008005493&rft_dat=%3Cproquest_cross%3E81316065%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81316065&rft_id=info:pmid/6208390&rft_sage_id=10.1177_0148607184008005493&rfr_iscdi=true |