Effects of Divalent Amino Acids on Iron Absorption
Solutions of each of 10 amino acids or ascorbic acid were mixed with iron and orally administered to rats. Iron was absorbed to a statistically significantly greater extent (p < 0.05) when mixed with asparagine, glycine, serine, or ascorbic acid as compared with a control solution of iron. The la...
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| Veröffentlicht in: | J. Pharm. Sci.; (United States) 1984-09, Vol.73 (9), p.1245-1248 |
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| creator | Christensen, John M. Ghannam, Musa Ayres, James W. |
| description | Solutions of each of 10 amino acids or ascorbic acid were mixed with iron and orally administered to rats. Iron was absorbed to a statistically significantly greater extent (p < 0.05) when mixed with asparagine, glycine, serine, or ascorbic acid as compared with a control solution of iron. The largest effects were for asparagine and glycine, which also increased iron absorption to a significantly greater extent (p < 0.001) than did serine or ascorbic acid. No statistically significant increase in iron absorption occurred when any of the other amino acids was mixed with iron. The extent of iron absorption from each test solution, as measured by area under the concentration of iron-59 in the blood-time curve (r2 = 0.0002), and the initial rate of iron absorption for each test solution (r2 = 0.01) showed no correlation with the stability constant of the amino acid-iron complex. |
| doi_str_mv | 10.1002/jps.2600730913 |
| format | Article |
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Iron was absorbed to a statistically significantly greater extent (p < 0.05) when mixed with asparagine, glycine, serine, or ascorbic acid as compared with a control solution of iron. The largest effects were for asparagine and glycine, which also increased iron absorption to a significantly greater extent (p < 0.001) than did serine or ascorbic acid. No statistically significant increase in iron absorption occurred when any of the other amino acids was mixed with iron. The extent of iron absorption from each test solution, as measured by area under the concentration of iron-59 in the blood-time curve (r2 = 0.0002), and the initial rate of iron absorption for each test solution (r2 = 0.01) showed no correlation with the stability constant of the amino acid-iron complex.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600730913</identifier><identifier>PMID: 6491942</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>550501 - Metabolism- Tracer Techniques ; ABSORPTION ; Absorption-iron ; Absorption—iron, effects of divalent amino acids ; AMINO ACIDS ; Amino Acids - pharmacology ; Amino acids-divalent ; Amino acids—divalent, effects on iron absorption ; ANIMALS ; ASCORBIC ACID ; Ascorbic Acid - pharmacology ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOCHEMICAL REACTION KINETICS ; Biological and medical sciences ; Buffers ; CARBOXYLIC ACIDS ; Complexes-iron-divalent amino acids ; Complexes—iron-divalent amino acids, effect on iron absorption ; DAYS LIVING RADIOISOTOPES ; effect on iron absorption ; effects of divalent amino acids ; effects on iron absorption ; ELEMENTS ; EVEN-ODD NUCLEI ; General and cellular metabolism. Vitamins ; INTERMEDIATE MASS NUCLEI ; INTESTINAL ABSORPTION ; Intestinal Absorption - drug effects ; IRON ; Iron - metabolism ; IRON 59 ; IRON ISOTOPES ; Iron Radioisotopes ; Iron-absorption ; Iron—absorption, effects of divalent amino acids ; ISOTOPE APPLICATIONS ; ISOTOPES ; KINETICS ; MAMMALS ; Medical sciences ; METALS ; NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; Pharmacology. Drug treatments ; RADIOISOTOPES ; RATS ; Rats, Inbred Strains ; REACTION KINETICS ; RESPONSE MODIFYING FACTORS ; RODENTS ; Tissue Distribution ; TRACER TECHNIQUES ; TRANSITION ELEMENTS ; UPTAKE ; VERTEBRATES ; VITAMINS</subject><ispartof>J. Pharm. Sci.; (United States), 1984-09, Vol.73 (9), p.1245-1248</ispartof><rights>1984 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4833-3ab911d20841bdb708f8bb5c6ff0c93ef5ae8a3b0a6da0d79ef8456be45f7f053</citedby><cites>FETCH-LOGICAL-c4833-3ab911d20841bdb708f8bb5c6ff0c93ef5ae8a3b0a6da0d79ef8456be45f7f053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600730913$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600730913$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9034233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6491942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5948070$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Christensen, John M.</creatorcontrib><creatorcontrib>Ghannam, Musa</creatorcontrib><creatorcontrib>Ayres, James W.</creatorcontrib><creatorcontrib>Oregon State Univ., Corvallis</creatorcontrib><title>Effects of Divalent Amino Acids on Iron Absorption</title><title>J. Pharm. Sci.; (United States)</title><addtitle>J. Pharm. Sci</addtitle><description>Solutions of each of 10 amino acids or ascorbic acid were mixed with iron and orally administered to rats. Iron was absorbed to a statistically significantly greater extent (p < 0.05) when mixed with asparagine, glycine, serine, or ascorbic acid as compared with a control solution of iron. The largest effects were for asparagine and glycine, which also increased iron absorption to a significantly greater extent (p < 0.001) than did serine or ascorbic acid. No statistically significant increase in iron absorption occurred when any of the other amino acids was mixed with iron. The extent of iron absorption from each test solution, as measured by area under the concentration of iron-59 in the blood-time curve (r2 = 0.0002), and the initial rate of iron absorption for each test solution (r2 = 0.01) showed no correlation with the stability constant of the amino acid-iron complex.</description><subject>550501 - Metabolism- Tracer Techniques</subject><subject>ABSORPTION</subject><subject>Absorption-iron</subject><subject>Absorption—iron, effects of divalent amino acids</subject><subject>AMINO ACIDS</subject><subject>Amino Acids - pharmacology</subject><subject>Amino acids-divalent</subject><subject>Amino acids—divalent, effects on iron absorption</subject><subject>ANIMALS</subject><subject>ASCORBIC ACID</subject><subject>Ascorbic Acid - pharmacology</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOCHEMICAL REACTION KINETICS</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>CARBOXYLIC ACIDS</subject><subject>Complexes-iron-divalent amino acids</subject><subject>Complexes—iron-divalent amino acids, effect on iron absorption</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>effect on iron absorption</subject><subject>effects of divalent amino acids</subject><subject>effects on iron absorption</subject><subject>ELEMENTS</subject><subject>EVEN-ODD NUCLEI</subject><subject>General and cellular metabolism. Vitamins</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTESTINAL ABSORPTION</subject><subject>Intestinal Absorption - drug effects</subject><subject>IRON</subject><subject>Iron - metabolism</subject><subject>IRON 59</subject><subject>IRON ISOTOPES</subject><subject>Iron Radioisotopes</subject><subject>Iron-absorption</subject><subject>Iron—absorption, effects of divalent amino acids</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>KINETICS</subject><subject>MAMMALS</subject><subject>Medical sciences</subject><subject>METALS</subject><subject>NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>Pharmacology. Drug treatments</subject><subject>RADIOISOTOPES</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>REACTION KINETICS</subject><subject>RESPONSE MODIFYING FACTORS</subject><subject>RODENTS</subject><subject>Tissue Distribution</subject><subject>TRACER TECHNIQUES</subject><subject>TRANSITION ELEMENTS</subject><subject>UPTAKE</subject><subject>VERTEBRATES</subject><subject>VITAMINS</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9vFCEUx4nR1LX16s1kYoy32T6GYQaOm25ta5q2pv66EYZ5ROosbGG22v9eNrNZ48F4gYT3-T4eHwh5RWFOAarju3WaVw1Ay0BS9oTMKK-gbIC2T8ksA1XJeC2fkxcp3QFAA5wfkIOmllTW1YxUp9aiGVMRbLF0D3pAPxaLlfOhWBjX53NfXMS8LLoU4np0wR-RZ1YPCV_u9kPy-f3pp5Pz8vL67OJkcVmaWjBWMt1JSvsKRE27vmtBWNF13DTWgpEMLdcoNOtAN72GvpVoRc2bDmtuWwucHZI3U9-QRqeScSOa7yZ4n-dVXNYCWsjQuwlax3C_wTSqlUsGh0F7DJukBGUgeE0zOJ9AE0NKEa1aR7fS8VFRUFuTKptUf0zmwOtd5023wn6P79Tl-ttdXSejBxu1Ny7tMQksQ9s2csJ-ugEf_3Op-nBz-9cI5ZR1acRf-6yOP1TTsparr1dn6vyWXi2_ffmolpkXE4_5Wx4cxq019AZ7F7fS-uD-9drfswSsQw</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Christensen, John M.</creator><creator>Ghannam, Musa</creator><creator>Ayres, James W.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198409</creationdate><title>Effects of Divalent Amino Acids on Iron Absorption</title><author>Christensen, John M. ; Ghannam, Musa ; Ayres, James W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4833-3ab911d20841bdb708f8bb5c6ff0c93ef5ae8a3b0a6da0d79ef8456be45f7f053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>550501 - Metabolism- Tracer Techniques</topic><topic>ABSORPTION</topic><topic>Absorption-iron</topic><topic>Absorption—iron, effects of divalent amino acids</topic><topic>AMINO ACIDS</topic><topic>Amino Acids - pharmacology</topic><topic>Amino acids-divalent</topic><topic>Amino acids—divalent, effects on iron absorption</topic><topic>ANIMALS</topic><topic>ASCORBIC ACID</topic><topic>Ascorbic Acid - pharmacology</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOCHEMICAL REACTION KINETICS</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>CARBOXYLIC ACIDS</topic><topic>Complexes-iron-divalent amino acids</topic><topic>Complexes—iron-divalent amino acids, effect on iron absorption</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>effect on iron absorption</topic><topic>effects of divalent amino acids</topic><topic>effects on iron absorption</topic><topic>ELEMENTS</topic><topic>EVEN-ODD NUCLEI</topic><topic>General and cellular metabolism. Vitamins</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTESTINAL ABSORPTION</topic><topic>Intestinal Absorption - drug effects</topic><topic>IRON</topic><topic>Iron - metabolism</topic><topic>IRON 59</topic><topic>IRON ISOTOPES</topic><topic>Iron Radioisotopes</topic><topic>Iron-absorption</topic><topic>Iron—absorption, effects of divalent amino acids</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>KINETICS</topic><topic>MAMMALS</topic><topic>Medical sciences</topic><topic>METALS</topic><topic>NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>Pharmacology. Drug treatments</topic><topic>RADIOISOTOPES</topic><topic>RATS</topic><topic>Rats, Inbred Strains</topic><topic>REACTION KINETICS</topic><topic>RESPONSE MODIFYING FACTORS</topic><topic>RODENTS</topic><topic>Tissue Distribution</topic><topic>TRACER TECHNIQUES</topic><topic>TRANSITION ELEMENTS</topic><topic>UPTAKE</topic><topic>VERTEBRATES</topic><topic>VITAMINS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christensen, John M.</creatorcontrib><creatorcontrib>Ghannam, Musa</creatorcontrib><creatorcontrib>Ayres, James W.</creatorcontrib><creatorcontrib>Oregon State Univ., Corvallis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Pharm. Sci.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christensen, John M.</au><au>Ghannam, Musa</au><au>Ayres, James W.</au><aucorp>Oregon State Univ., Corvallis</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Divalent Amino Acids on Iron Absorption</atitle><jtitle>J. Pharm. Sci.; (United States)</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1984-09</date><risdate>1984</risdate><volume>73</volume><issue>9</issue><spage>1245</spage><epage>1248</epage><pages>1245-1248</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Solutions of each of 10 amino acids or ascorbic acid were mixed with iron and orally administered to rats. Iron was absorbed to a statistically significantly greater extent (p < 0.05) when mixed with asparagine, glycine, serine, or ascorbic acid as compared with a control solution of iron. The largest effects were for asparagine and glycine, which also increased iron absorption to a significantly greater extent (p < 0.001) than did serine or ascorbic acid. No statistically significant increase in iron absorption occurred when any of the other amino acids was mixed with iron. The extent of iron absorption from each test solution, as measured by area under the concentration of iron-59 in the blood-time curve (r2 = 0.0002), and the initial rate of iron absorption for each test solution (r2 = 0.01) showed no correlation with the stability constant of the amino acid-iron complex.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6491942</pmid><doi>10.1002/jps.2600730913</doi><tpages>4</tpages></addata></record> |
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| ispartof | J. Pharm. Sci.; (United States), 1984-09, Vol.73 (9), p.1245-1248 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| subjects | 550501 - Metabolism- Tracer Techniques ABSORPTION Absorption-iron Absorption—iron, effects of divalent amino acids AMINO ACIDS Amino Acids - pharmacology Amino acids-divalent Amino acids—divalent, effects on iron absorption ANIMALS ASCORBIC ACID Ascorbic Acid - pharmacology BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS Biological and medical sciences Buffers CARBOXYLIC ACIDS Complexes-iron-divalent amino acids Complexes—iron-divalent amino acids, effect on iron absorption DAYS LIVING RADIOISOTOPES effect on iron absorption effects of divalent amino acids effects on iron absorption ELEMENTS EVEN-ODD NUCLEI General and cellular metabolism. Vitamins INTERMEDIATE MASS NUCLEI INTESTINAL ABSORPTION Intestinal Absorption - drug effects IRON Iron - metabolism IRON 59 IRON ISOTOPES Iron Radioisotopes Iron-absorption Iron—absorption, effects of divalent amino acids ISOTOPE APPLICATIONS ISOTOPES KINETICS MAMMALS Medical sciences METALS NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS Pharmacology. Drug treatments RADIOISOTOPES RATS Rats, Inbred Strains REACTION KINETICS RESPONSE MODIFYING FACTORS RODENTS Tissue Distribution TRACER TECHNIQUES TRANSITION ELEMENTS UPTAKE VERTEBRATES VITAMINS |
| title | Effects of Divalent Amino Acids on Iron Absorption |
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