Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal

To clarify the enzymatic mechanisms of brain damage in thiamin deficiency, glucose oxidation, acetylcholine synthesis, and the activities of the three major thiamin pyrophosphate (TPP) dependent brain enzymes were compared in untreated controls, in symptomatic pyrithiamin-induced thiamin-deficient r...

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Veröffentlicht in:	Neurochemical research 1984-06, Vol.9 (6), p.803-814
Hauptverfasser:	GIBSON, G. E, KSIEZAK-REDING, H, KWAN-FU REX SHEU, MYKYTYN, V, BLASS, J. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - enzymology Brain - metabolism Hexokinase - metabolism Ketoglutarate Dehydrogenase Complex - metabolism Male Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Pyruvate Dehydrogenase Complex - metabolism Rats Rats, Inbred Strains Thiamine Deficiency - enzymology Thiamine Deficiency - metabolism Thiamine Pyrophosphatase - metabolism Transketolase - metabolism
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