Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats
The effects of biotin and protein-calorie deficiency on metabolism of liver phospholipids in rats were determined. Weanling male Long-Evans rats were fed ad libitum a biotin-deficient (0.4 µg biotin/g diet) or a biotin-adequate (2.4 µg biotin/g diet) diet for 49 days. A pair-fed group was fed biotin...
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| Veröffentlicht in: | The Journal of nutrition 1984-11, Vol.114 (11), p.2047-2052 |
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| creator | Kramer, Tim R. Briske-Anderson, Mary Johnson, Susan B. Holman, Ralph T. |
| description | The effects of biotin and protein-calorie deficiency on metabolism of liver phospholipids in rats were determined. Weanling male Long-Evans rats were fed ad libitum a biotin-deficient (0.4 µg biotin/g diet) or a biotin-adequate (2.4 µg biotin/g diet) diet for 49 days. A pair-fed group was fed biotin-adequate diet but restricted to the amount consumed by biotin-deficient rats. The effects of these diets on food intake, weight gain, biotin content of serum and fatty acid composition of liver phospholipid were determined. Growth and food intake were significantly depressed in biotin-deficient and pair-fed rats. Biotin concentration in serum was significantly reduced in biotin-deficient and in pair-fed rats. Biotin deficiency caused significantly increased concentrations of 15:0, 17:0 and total odd-chain fatty acids in liver phospholipids. Combined biotin and protein-calorie deficiency and protein-calorie deficiency alone caused significantly increased concentrations of 18:2ω6 in liver phospholipids. Biotin deficiency caused significant reduction in liver phospholipid 20:3ω6. Reduced arachidonic acid (20:4ω6) level was due to combined biotin protein-calorie deficiency. Protein-calorie deficiency alone was primarily responsible for reduced levels of 22:5ω6. Biotin deficiency alone caused significant increases in liver phospholipids 18:3ω3 and 22:6ω3. |
| doi_str_mv | 10.1093/jn/114.11.2047 |
| format | Article |
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Weanling male Long-Evans rats were fed ad libitum a biotin-deficient (0.4 µg biotin/g diet) or a biotin-adequate (2.4 µg biotin/g diet) diet for 49 days. A pair-fed group was fed biotin-adequate diet but restricted to the amount consumed by biotin-deficient rats. The effects of these diets on food intake, weight gain, biotin content of serum and fatty acid composition of liver phospholipid were determined. Growth and food intake were significantly depressed in biotin-deficient and pair-fed rats. Biotin concentration in serum was significantly reduced in biotin-deficient and in pair-fed rats. Biotin deficiency caused significantly increased concentrations of 15:0, 17:0 and total odd-chain fatty acids in liver phospholipids. Combined biotin and protein-calorie deficiency and protein-calorie deficiency alone caused significantly increased concentrations of 18:2ω6 in liver phospholipids. Biotin deficiency caused significant reduction in liver phospholipid 20:3ω6. Reduced arachidonic acid (20:4ω6) level was due to combined biotin protein-calorie deficiency. Protein-calorie deficiency alone was primarily responsible for reduced levels of 22:5ω6. Biotin deficiency alone caused significant increases in liver phospholipids 18:3ω3 and 22:6ω3.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/114.11.2047</identifier><identifier>PMID: 6436451</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; BIOTIN ; Biotin - deficiency ; BIOTINA ; BIOTINE ; Body Weight ; CORPS GRAS ; DEFICIENCY DISEASES ; Diet ; ENFERMEDADES CARENCIALES ; FATS ; Fatty Acids, Unsaturated - metabolism ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; GRASAS ; Liver - metabolism ; MALADIE DE CARENCE ; Male ; METABOLISM ; METABOLISME ; METABOLISMO ; phospholipid fatty acids ; Phospholipids - metabolism ; polyunsaturated fatty acids ; protein-calorie deficiency ; Protein-Energy Malnutrition - metabolism ; RAT ; RATA ; RATS ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 1984-11, Vol.114 (11), p.2047-2052</ispartof><rights>1984 American Society for Nutrition.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4087-a266bccb21b65477c661e4d986468242b405177afa4cb0222519e1e3195b902a3</citedby><cites>FETCH-LOGICAL-c4087-a266bccb21b65477c661e4d986468242b405177afa4cb0222519e1e3195b902a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9121856$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6436451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kramer, Tim R.</creatorcontrib><creatorcontrib>Briske-Anderson, Mary</creatorcontrib><creatorcontrib>Johnson, Susan B.</creatorcontrib><creatorcontrib>Holman, Ralph T.</creatorcontrib><title>Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The effects of biotin and protein-calorie deficiency on metabolism of liver phospholipids in rats were determined. Weanling male Long-Evans rats were fed ad libitum a biotin-deficient (0.4 µg biotin/g diet) or a biotin-adequate (2.4 µg biotin/g diet) diet for 49 days. A pair-fed group was fed biotin-adequate diet but restricted to the amount consumed by biotin-deficient rats. The effects of these diets on food intake, weight gain, biotin content of serum and fatty acid composition of liver phospholipid were determined. Growth and food intake were significantly depressed in biotin-deficient and pair-fed rats. Biotin concentration in serum was significantly reduced in biotin-deficient and in pair-fed rats. Biotin deficiency caused significantly increased concentrations of 15:0, 17:0 and total odd-chain fatty acids in liver phospholipids. Combined biotin and protein-calorie deficiency and protein-calorie deficiency alone caused significantly increased concentrations of 18:2ω6 in liver phospholipids. Biotin deficiency caused significant reduction in liver phospholipid 20:3ω6. Reduced arachidonic acid (20:4ω6) level was due to combined biotin protein-calorie deficiency. Protein-calorie deficiency alone was primarily responsible for reduced levels of 22:5ω6. Biotin deficiency alone caused significant increases in liver phospholipids 18:3ω3 and 22:6ω3.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BIOTIN</subject><subject>Biotin - deficiency</subject><subject>BIOTINA</subject><subject>BIOTINE</subject><subject>Body Weight</subject><subject>CORPS GRAS</subject><subject>DEFICIENCY DISEASES</subject><subject>Diet</subject><subject>ENFERMEDADES CARENCIALES</subject><subject>FATS</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GRASAS</subject><subject>Liver - metabolism</subject><subject>MALADIE DE CARENCE</subject><subject>Male</subject><subject>METABOLISM</subject><subject>METABOLISME</subject><subject>METABOLISMO</subject><subject>phospholipid fatty acids</subject><subject>Phospholipids - metabolism</subject><subject>polyunsaturated fatty acids</subject><subject>protein-calorie deficiency</subject><subject>Protein-Energy Malnutrition - metabolism</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kT1vFDEQhi0ECpdAS4GE5AKl24vHa3u9ZcgHiZQIBKS2Zr028mlvHWwv0v37ONwpHcXIxfvMaOYxIR-ArYH17dlmPgMQa4A1Z6J7RVYgBTQKGHtNVoxx3rSg1FtynPOGMQai10fkSIlWCQkrcn_lvbMl0-jplxBLmOml88EGN9sdjTP9HqfdMmcsS8LiRnqNpezouQ0jvXcFhziFvKW17QeW_I688Thl9_7wnpCH66tfFzfN3bevtxfnd40VTHcNcqUGawcOg5Ki66xS4MTYayWU5oIPgknoOvQo7FBP4BJ6B66FXg4949iekNP93McU_ywuF7MN2bppwtnFJRsNLVOS6Qqu96BNMefkvHlMYYtpZ4CZZ39mM5vqr5Z59lcbPh0mL8PWjS_4QVjNPx9yzBYnn3C2Ib9gPXDQUlXs4x7zGA3-ThV5-KkVdEL2NdT70FVFf4NLJv_z7caQ6l-YMYb_rfcEHDqQ3w</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>Kramer, Tim R.</creator><creator>Briske-Anderson, Mary</creator><creator>Johnson, Susan B.</creator><creator>Holman, Ralph T.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats</title><author>Kramer, Tim R. ; Briske-Anderson, Mary ; Johnson, Susan B. ; Holman, Ralph T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4087-a266bccb21b65477c661e4d986468242b405177afa4cb0222519e1e3195b902a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BIOTIN</topic><topic>Biotin - deficiency</topic><topic>BIOTINA</topic><topic>BIOTINE</topic><topic>Body Weight</topic><topic>CORPS GRAS</topic><topic>DEFICIENCY DISEASES</topic><topic>Diet</topic><topic>ENFERMEDADES CARENCIALES</topic><topic>FATS</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GRASAS</topic><topic>Liver - metabolism</topic><topic>MALADIE DE CARENCE</topic><topic>Male</topic><topic>METABOLISM</topic><topic>METABOLISME</topic><topic>METABOLISMO</topic><topic>phospholipid fatty acids</topic><topic>Phospholipids - metabolism</topic><topic>polyunsaturated fatty acids</topic><topic>protein-calorie deficiency</topic><topic>Protein-Energy Malnutrition - metabolism</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kramer, Tim R.</creatorcontrib><creatorcontrib>Briske-Anderson, Mary</creatorcontrib><creatorcontrib>Johnson, Susan B.</creatorcontrib><creatorcontrib>Holman, Ralph T.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kramer, Tim R.</au><au>Briske-Anderson, Mary</au><au>Johnson, Susan B.</au><au>Holman, Ralph T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1984-11</date><risdate>1984</risdate><volume>114</volume><issue>11</issue><spage>2047</spage><epage>2052</epage><pages>2047-2052</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The effects of biotin and protein-calorie deficiency on metabolism of liver phospholipids in rats were determined. Weanling male Long-Evans rats were fed ad libitum a biotin-deficient (0.4 µg biotin/g diet) or a biotin-adequate (2.4 µg biotin/g diet) diet for 49 days. A pair-fed group was fed biotin-adequate diet but restricted to the amount consumed by biotin-deficient rats. The effects of these diets on food intake, weight gain, biotin content of serum and fatty acid composition of liver phospholipid were determined. Growth and food intake were significantly depressed in biotin-deficient and pair-fed rats. Biotin concentration in serum was significantly reduced in biotin-deficient and in pair-fed rats. Biotin deficiency caused significantly increased concentrations of 15:0, 17:0 and total odd-chain fatty acids in liver phospholipids. Combined biotin and protein-calorie deficiency and protein-calorie deficiency alone caused significantly increased concentrations of 18:2ω6 in liver phospholipids. Biotin deficiency caused significant reduction in liver phospholipid 20:3ω6. Reduced arachidonic acid (20:4ω6) level was due to combined biotin protein-calorie deficiency. Protein-calorie deficiency alone was primarily responsible for reduced levels of 22:5ω6. Biotin deficiency alone caused significant increases in liver phospholipids 18:3ω3 and 22:6ω3.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6436451</pmid><doi>10.1093/jn/114.11.2047</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences BIOTIN Biotin - deficiency BIOTINA BIOTINE Body Weight CORPS GRAS DEFICIENCY DISEASES Diet ENFERMEDADES CARENCIALES FATS Fatty Acids, Unsaturated - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology GRASAS Liver - metabolism MALADIE DE CARENCE Male METABOLISM METABOLISME METABOLISMO phospholipid fatty acids Phospholipids - metabolism polyunsaturated fatty acids protein-calorie deficiency Protein-Energy Malnutrition - metabolism RAT RATA RATS Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of Biotin Deficiency on Polyunsaturated Fatty Acid Metabolism in Rats |
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