Interaction between Ethanol and Low Dietary Zinc during Gestation and Lactation in the Rat
Pregnant rats were fed individual liquid diets throughout gestation and lactation. The diets contained either 2 or 10 µg zinc/ml diet with or without 30% of the kilocalories supplied from ethanol. The low zinc diet produced a moderate zinc deficiency in dams evidenced by decreases in tissue zinc con...
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| Veröffentlicht in: | The Journal of nutrition 1984-11, Vol.114 (11), p.2027-2033 |
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| container_end_page | 2033 |
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| container_issue | 11 |
| container_start_page | 2027 |
| container_title | The Journal of nutrition |
| container_volume | 114 |
| creator | Yeh, Lee-Chuan C. Cerklewski, Florian L. |
| description | Pregnant rats were fed individual liquid diets throughout gestation and lactation. The diets contained either 2 or 10 µg zinc/ml diet with or without 30% of the kilocalories supplied from ethanol. The low zinc diet produced a moderate zinc deficiency in dams evidenced by decreases in tissue zinc content, serum alkaline phosphatase activity and urinary zinc concentration. Despite the presence of high zinc content in the diet, ethanol antagonized the maternal zinc status to a level typical of that produced by the low zinc diet. The lowest zinc status, however, was found when low dietary zinc and ethanol were combined. The maternal interaction between ethanol and zinc also depressed offspring serum zinc and alkaline phosphatase activity in a similar manner. Ethanol, however, did not affect tissue content of calcium, magnesium or phosphorus, which indicates that ethanol is a specific antagonist of zinc utilization during gestation and lactation. |
| doi_str_mv | 10.1093/jn/114.11.2027 |
| format | Article |
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The diets contained either 2 or 10 µg zinc/ml diet with or without 30% of the kilocalories supplied from ethanol. The low zinc diet produced a moderate zinc deficiency in dams evidenced by decreases in tissue zinc content, serum alkaline phosphatase activity and urinary zinc concentration. Despite the presence of high zinc content in the diet, ethanol antagonized the maternal zinc status to a level typical of that produced by the low zinc diet. The lowest zinc status, however, was found when low dietary zinc and ethanol were combined. The maternal interaction between ethanol and zinc also depressed offspring serum zinc and alkaline phosphatase activity in a similar manner. Ethanol, however, did not affect tissue content of calcium, magnesium or phosphorus, which indicates that ethanol is a specific antagonist of zinc utilization during gestation and lactation.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/114.11.2027</identifier><identifier>PMID: 6491758</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Alcoholism and acute alcohol poisoning ; Alkaline Phosphatase - blood ; Animals ; Biological and medical sciences ; Diet ; Energy Intake ; ethanol ; Ethanol - pharmacology ; Female ; Lactation ; Medical sciences ; Minerals - metabolism ; Pregnancy ; Pregnancy, Animal ; Rats ; Toxicology ; zinc ; Zinc - blood ; Zinc - deficiency ; Zinc - urine</subject><ispartof>The Journal of nutrition, 1984-11, Vol.114 (11), p.2027-2033</ispartof><rights>1984 American Society for Nutrition.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-40ecf7baf717740d6749b033976c0ff0c9cbd2a825c988f183f4de3f4bd9bd5a3</citedby><cites>FETCH-LOGICAL-c408t-40ecf7baf717740d6749b033976c0ff0c9cbd2a825c988f183f4de3f4bd9bd5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9127247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6491758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Lee-Chuan C.</creatorcontrib><creatorcontrib>Cerklewski, Florian L.</creatorcontrib><title>Interaction between Ethanol and Low Dietary Zinc during Gestation and Lactation in the Rat</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Pregnant rats were fed individual liquid diets throughout gestation and lactation. The diets contained either 2 or 10 µg zinc/ml diet with or without 30% of the kilocalories supplied from ethanol. The low zinc diet produced a moderate zinc deficiency in dams evidenced by decreases in tissue zinc content, serum alkaline phosphatase activity and urinary zinc concentration. Despite the presence of high zinc content in the diet, ethanol antagonized the maternal zinc status to a level typical of that produced by the low zinc diet. The lowest zinc status, however, was found when low dietary zinc and ethanol were combined. The maternal interaction between ethanol and zinc also depressed offspring serum zinc and alkaline phosphatase activity in a similar manner. Ethanol, however, did not affect tissue content of calcium, magnesium or phosphorus, which indicates that ethanol is a specific antagonist of zinc utilization during gestation and lactation.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Alkaline Phosphatase - blood</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diet</subject><subject>Energy Intake</subject><subject>ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Lactation</subject><subject>Medical sciences</subject><subject>Minerals - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal</subject><subject>Rats</subject><subject>Toxicology</subject><subject>zinc</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><subject>Zinc - urine</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFPHCEUh4mx0a167c2Eg-lt1scMO8DRWGtNNmli9OKFMPCobGYZBVbT_76su_HWA5CX971fHh8h3xjMGajuchUvGeNzxuYttOKAzNiCs6ZnAIdkBtC2Tcf6_ph8zXkFAIwreUSOeq6YWMgZebqLBZOxJUyRDljeESO9Kc8mTiM10dHl9E5_BCwm_aVPIVrqNinEP_QWczEfUx9UTdhVIdLyjPTelFPyxZsx49n-PSGPP28ern81y9-3d9dXy8ZykKXhgNaLwXjBhODgesHVAF2nRG_Be7DKDq41sl1YJaVnsvPcYb0Gpwa3MN0J-b7LfUnT66aupdchWxxHE3HaZC1ZBz3voYLzHWjTlHNCr19SWNePaQZ6K1Ovoq4y69FbmXXgfJ-8GdboPvG9vdq_2PdNtmb0yUQb8iemWCtavo2ROwyrhbeASWcbMFp0IaEt2k3hfxv8A2tKj1M</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>Yeh, Lee-Chuan C.</creator><creator>Cerklewski, Florian L.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Interaction between Ethanol and Low Dietary Zinc during Gestation and Lactation in the Rat</title><author>Yeh, Lee-Chuan C. ; Cerklewski, Florian L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-40ecf7baf717740d6749b033976c0ff0c9cbd2a825c988f183f4de3f4bd9bd5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Alkaline Phosphatase - blood</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diet</topic><topic>Energy Intake</topic><topic>ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Lactation</topic><topic>Medical sciences</topic><topic>Minerals - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal</topic><topic>Rats</topic><topic>Toxicology</topic><topic>zinc</topic><topic>Zinc - blood</topic><topic>Zinc - deficiency</topic><topic>Zinc - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Lee-Chuan C.</creatorcontrib><creatorcontrib>Cerklewski, Florian L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Lee-Chuan C.</au><au>Cerklewski, Florian L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between Ethanol and Low Dietary Zinc during Gestation and Lactation in the Rat</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1984-11</date><risdate>1984</risdate><volume>114</volume><issue>11</issue><spage>2027</spage><epage>2033</epage><pages>2027-2033</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Pregnant rats were fed individual liquid diets throughout gestation and lactation. The diets contained either 2 or 10 µg zinc/ml diet with or without 30% of the kilocalories supplied from ethanol. The low zinc diet produced a moderate zinc deficiency in dams evidenced by decreases in tissue zinc content, serum alkaline phosphatase activity and urinary zinc concentration. Despite the presence of high zinc content in the diet, ethanol antagonized the maternal zinc status to a level typical of that produced by the low zinc diet. The lowest zinc status, however, was found when low dietary zinc and ethanol were combined. The maternal interaction between ethanol and zinc also depressed offspring serum zinc and alkaline phosphatase activity in a similar manner. Ethanol, however, did not affect tissue content of calcium, magnesium or phosphorus, which indicates that ethanol is a specific antagonist of zinc utilization during gestation and lactation.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6491758</pmid><doi>10.1093/jn/114.11.2027</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1984-11, Vol.114 (11), p.2027-2033 |
| issn | 0022-3166 1541-6100 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alcoholism and acute alcohol poisoning Alkaline Phosphatase - blood Animals Biological and medical sciences Diet Energy Intake ethanol Ethanol - pharmacology Female Lactation Medical sciences Minerals - metabolism Pregnancy Pregnancy, Animal Rats Toxicology zinc Zinc - blood Zinc - deficiency Zinc - urine |
| title | Interaction between Ethanol and Low Dietary Zinc during Gestation and Lactation in the Rat |
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