Peripheral nerve morphometry in stroke patients
Sural nerve biopsy specimens from affected and non-affected limbs of stroke patients were examined morphometrically. Two principle abnormalities of peripheral nerve were found in hemiparetic and hemiplegic limbs. First, the frequency of abnormal teased nerve fibers was significantly increased with a...
Gespeichert in:
| Veröffentlicht in: | Journal of the neurological sciences 1984-09, Vol.65 (3), p.341-352 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 352 |
|---|---|
| container_issue | 3 |
| container_start_page | 341 |
| container_title | Journal of the neurological sciences |
| container_volume | 65 |
| creator | Pollock, Martin Nukada, Hitoshi Allpress, Stephen Calder, Christopher Mackinnon, Murray |
| description | Sural nerve biopsy specimens from affected and non-affected limbs of stroke patients were examined morphometrically. Two principle abnormalities of peripheral nerve were found in hemiparetic and hemiplegic limbs. First, the frequency of abnormal teased nerve fibers was significantly increased with abnormal internodes frequently “clustered” and showing a 50% or more reduction in myelin thickness. Second, the mean diameter of myelinated nerve fibers was reduced. These results suggest a primary atrophy of peripheral nerve fibers in the affected limbs of stroke patients with secondary demyelination. Possible aetiological factors include disuse, transynaptic degeneration, ischemia, pressure effect, and decreased axoplasmic flow. It would seem that the structural integrity of peripheral nerve is frequently compromised following a cerebral lesion. |
| doi_str_mv | 10.1016/0022-510X(84)90097-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81306108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0022510X84900972</els_id><sourcerecordid>81306108</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-57fc27d68cf0ceee8cbfcee334ac5be12f3f0bf236c332de9f6a8ce116665c4a3</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMotVb_gcIsRHQx9iaZyWQ2ghRfUNCFgruQZm5odF4m00L_vTO2dOnqLs53DpePkHMKtxSomAIwFqcUPq9lcpMD5FnMDsiYykzGqZT8kIz3yDE5CeELAISU-YiMRJJTkSdjMn1D79olel1GNfo1RlXj22VTYec3kauj0PnmG6NWdw7rLpySI6vLgGe7OyEfjw_vs-d4_vr0Mrufx4ZL0cVpZg3LCiGNBYOI0ixsfzlPtEkXSJnlFhaWcWE4ZwXmVmhpkFIhRGoSzSfkarvb-uZnhaFTlQsGy1LX2KyCkpSDoCB7MNmCxjcheLSq9a7SfqMoqMGTGiSoQYKSifrzpFhfu9jtrxYVFvvSTkyfX-5yHYwurde1cWGP5UCBZcPM3RbD3sXaoVfB9J4MFs6j6VTRuP__-AUZlITe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81306108</pqid></control><display><type>article</type><title>Peripheral nerve morphometry in stroke patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pollock, Martin ; Nukada, Hitoshi ; Allpress, Stephen ; Calder, Christopher ; Mackinnon, Murray</creator><creatorcontrib>Pollock, Martin ; Nukada, Hitoshi ; Allpress, Stephen ; Calder, Christopher ; Mackinnon, Murray</creatorcontrib><description>Sural nerve biopsy specimens from affected and non-affected limbs of stroke patients were examined morphometrically. Two principle abnormalities of peripheral nerve were found in hemiparetic and hemiplegic limbs. First, the frequency of abnormal teased nerve fibers was significantly increased with abnormal internodes frequently “clustered” and showing a 50% or more reduction in myelin thickness. Second, the mean diameter of myelinated nerve fibers was reduced. These results suggest a primary atrophy of peripheral nerve fibers in the affected limbs of stroke patients with secondary demyelination. Possible aetiological factors include disuse, transynaptic degeneration, ischemia, pressure effect, and decreased axoplasmic flow. It would seem that the structural integrity of peripheral nerve is frequently compromised following a cerebral lesion.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(84)90097-2</identifier><identifier>PMID: 6491694</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Aged ; Axons - ultrastructure ; Biological and medical sciences ; Biopsy ; Cerebral Infarction - pathology ; Demyelinating Diseases - pathology ; Female ; Hemiplegia - pathology ; Humans ; Male ; Medical sciences ; Microscopy, Electron ; Middle Aged ; Morphometry ; Myelin Sheath - ultrastructure ; Nerve biopsy ; Nerve Fibers, Myelinated - ultrastructure ; Neurology ; Peripheral nerve ; Schwann Cells - ultrastructure ; Spinal Nerves - pathology ; Stroke ; Sural Nerve - pathology ; Tumors of the nervous system. Phacomatoses ; Wallerian Degeneration</subject><ispartof>Journal of the neurological sciences, 1984-09, Vol.65 (3), p.341-352</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-57fc27d68cf0ceee8cbfcee334ac5be12f3f0bf236c332de9f6a8ce116665c4a3</citedby><cites>FETCH-LOGICAL-c386t-57fc27d68cf0ceee8cbfcee334ac5be12f3f0bf236c332de9f6a8ce116665c4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X84900972$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9010272$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6491694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pollock, Martin</creatorcontrib><creatorcontrib>Nukada, Hitoshi</creatorcontrib><creatorcontrib>Allpress, Stephen</creatorcontrib><creatorcontrib>Calder, Christopher</creatorcontrib><creatorcontrib>Mackinnon, Murray</creatorcontrib><title>Peripheral nerve morphometry in stroke patients</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Sural nerve biopsy specimens from affected and non-affected limbs of stroke patients were examined morphometrically. Two principle abnormalities of peripheral nerve were found in hemiparetic and hemiplegic limbs. First, the frequency of abnormal teased nerve fibers was significantly increased with abnormal internodes frequently “clustered” and showing a 50% or more reduction in myelin thickness. Second, the mean diameter of myelinated nerve fibers was reduced. These results suggest a primary atrophy of peripheral nerve fibers in the affected limbs of stroke patients with secondary demyelination. Possible aetiological factors include disuse, transynaptic degeneration, ischemia, pressure effect, and decreased axoplasmic flow. It would seem that the structural integrity of peripheral nerve is frequently compromised following a cerebral lesion.</description><subject>Adult</subject><subject>Aged</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cerebral Infarction - pathology</subject><subject>Demyelinating Diseases - pathology</subject><subject>Female</subject><subject>Hemiplegia - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Morphometry</subject><subject>Myelin Sheath - ultrastructure</subject><subject>Nerve biopsy</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Neurology</subject><subject>Peripheral nerve</subject><subject>Schwann Cells - ultrastructure</subject><subject>Spinal Nerves - pathology</subject><subject>Stroke</subject><subject>Sural Nerve - pathology</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Wallerian Degeneration</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotVb_gcIsRHQx9iaZyWQ2ghRfUNCFgruQZm5odF4m00L_vTO2dOnqLs53DpePkHMKtxSomAIwFqcUPq9lcpMD5FnMDsiYykzGqZT8kIz3yDE5CeELAISU-YiMRJJTkSdjMn1D79olel1GNfo1RlXj22VTYec3kauj0PnmG6NWdw7rLpySI6vLgGe7OyEfjw_vs-d4_vr0Mrufx4ZL0cVpZg3LCiGNBYOI0ixsfzlPtEkXSJnlFhaWcWE4ZwXmVmhpkFIhRGoSzSfkarvb-uZnhaFTlQsGy1LX2KyCkpSDoCB7MNmCxjcheLSq9a7SfqMoqMGTGiSoQYKSifrzpFhfu9jtrxYVFvvSTkyfX-5yHYwurde1cWGP5UCBZcPM3RbD3sXaoVfB9J4MFs6j6VTRuP__-AUZlITe</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Pollock, Martin</creator><creator>Nukada, Hitoshi</creator><creator>Allpress, Stephen</creator><creator>Calder, Christopher</creator><creator>Mackinnon, Murray</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198409</creationdate><title>Peripheral nerve morphometry in stroke patients</title><author>Pollock, Martin ; Nukada, Hitoshi ; Allpress, Stephen ; Calder, Christopher ; Mackinnon, Murray</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-57fc27d68cf0ceee8cbfcee334ac5be12f3f0bf236c332de9f6a8ce116665c4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cerebral Infarction - pathology</topic><topic>Demyelinating Diseases - pathology</topic><topic>Female</topic><topic>Hemiplegia - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Morphometry</topic><topic>Myelin Sheath - ultrastructure</topic><topic>Nerve biopsy</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Neurology</topic><topic>Peripheral nerve</topic><topic>Schwann Cells - ultrastructure</topic><topic>Spinal Nerves - pathology</topic><topic>Stroke</topic><topic>Sural Nerve - pathology</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Wallerian Degeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pollock, Martin</creatorcontrib><creatorcontrib>Nukada, Hitoshi</creatorcontrib><creatorcontrib>Allpress, Stephen</creatorcontrib><creatorcontrib>Calder, Christopher</creatorcontrib><creatorcontrib>Mackinnon, Murray</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pollock, Martin</au><au>Nukada, Hitoshi</au><au>Allpress, Stephen</au><au>Calder, Christopher</au><au>Mackinnon, Murray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral nerve morphometry in stroke patients</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1984-09</date><risdate>1984</risdate><volume>65</volume><issue>3</issue><spage>341</spage><epage>352</epage><pages>341-352</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Sural nerve biopsy specimens from affected and non-affected limbs of stroke patients were examined morphometrically. Two principle abnormalities of peripheral nerve were found in hemiparetic and hemiplegic limbs. First, the frequency of abnormal teased nerve fibers was significantly increased with abnormal internodes frequently “clustered” and showing a 50% or more reduction in myelin thickness. Second, the mean diameter of myelinated nerve fibers was reduced. These results suggest a primary atrophy of peripheral nerve fibers in the affected limbs of stroke patients with secondary demyelination. Possible aetiological factors include disuse, transynaptic degeneration, ischemia, pressure effect, and decreased axoplasmic flow. It would seem that the structural integrity of peripheral nerve is frequently compromised following a cerebral lesion.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>6491694</pmid><doi>10.1016/0022-510X(84)90097-2</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1984-09, Vol.65 (3), p.341-352 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81306108 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Axons - ultrastructure Biological and medical sciences Biopsy Cerebral Infarction - pathology Demyelinating Diseases - pathology Female Hemiplegia - pathology Humans Male Medical sciences Microscopy, Electron Middle Aged Morphometry Myelin Sheath - ultrastructure Nerve biopsy Nerve Fibers, Myelinated - ultrastructure Neurology Peripheral nerve Schwann Cells - ultrastructure Spinal Nerves - pathology Stroke Sural Nerve - pathology Tumors of the nervous system. Phacomatoses Wallerian Degeneration |
| title | Peripheral nerve morphometry in stroke patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T03%3A41%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peripheral%20nerve%20morphometry%20in%20stroke%20patients&rft.jtitle=Journal%20of%20the%20neurological%20sciences&rft.au=Pollock,%20Martin&rft.date=1984-09&rft.volume=65&rft.issue=3&rft.spage=341&rft.epage=352&rft.pages=341-352&rft.issn=0022-510X&rft.eissn=1878-5883&rft.coden=JNSCAG&rft_id=info:doi/10.1016/0022-510X(84)90097-2&rft_dat=%3Cproquest_cross%3E81306108%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81306108&rft_id=info:pmid/6491694&rft_els_id=0022510X84900972&rfr_iscdi=true |