Neurochemical and activity changes in rats infected with Trypanosoma brucei Gambiense
The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%. DOPAC lev...
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| Veröffentlicht in: | The Journal of parasitology 1984-06, Vol.70 (3), p.428-432 |
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| container_title | The Journal of parasitology |
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| creator | Stibbs, H.H |
| description | The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%. DOPAC levels declined by 30% in the caudate, but this change was significant at only P < 0.1. In the pons/medulla of infected rats the serotonin concentration dropped by 21% and the 5-HIAA concentration rose by 25%. Activity levels in infected rats decreased by 49% (gross movement) and 44% (total movement) relative to those of uninfected control rats. |
| doi_str_mv | 10.2307/3281576 |
| format | Article |
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In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%. DOPAC levels declined by 30% in the caudate, but this change was significant at only P < 0.1. In the pons/medulla of infected rats the serotonin concentration dropped by 21% and the 5-HIAA concentration rose by 25%. 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In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%. DOPAC levels declined by 30% in the caudate, but this change was significant at only P < 0.1. In the pons/medulla of infected rats the serotonin concentration dropped by 21% and the 5-HIAA concentration rose by 25%. Activity levels in infected rats decreased by 49% (gross movement) and 44% (total movement) relative to those of uninfected control rats.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Animals</subject><subject>BEHAVIOUR</subject><subject>BRAIN</subject><subject>Brain - metabolism</subject><subject>CATECHOLAMINE</subject><subject>CATECHOLAMINES</subject><subject>CATECOLAMINAS</subject><subject>Caudate Nucleus - metabolism</subject><subject>CEREBRO</subject><subject>COMPORTAMIENTO</subject><subject>COMPORTEMENT</subject><subject>DIHYDROXYPHENYLACETIC ACID</subject><subject>Dopamine - metabolism</subject><subject>ENCEPHALE</subject><subject>Experimental</subject><subject>Female</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>Infections</subject><subject>LOCOMOCION</subject><subject>LOCOMOTION</subject><subject>MEDICAMENT NEUROTROPE</subject><subject>MEDICAMENTOS NEUROTROPICOS</subject><subject>Medulla Oblongata - metabolism</subject><subject>Metabolism</subject><subject>Motor Activity</subject><subject>Nervous system diseases</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>NEUROTRANSMITTERS</subject><subject>NEUROTROPIC DRUGS</subject><subject>Parasitism</subject><subject>Parasitology</subject><subject>Pathology</subject><subject>Phenylacetates - metabolism</subject><subject>Pons - metabolism</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>Serotonin - metabolism</subject><subject>TRYPANOSOMA</subject><subject>Trypanosoma brucei gambiense</subject><subject>TRYPANOSOMA GAMBIENSE</subject><subject>Trypanosomiasis</subject><subject>Trypanosomiasis, African - metabolism</subject><subject>Trypanosomiasis, African - physiopathology</subject><subject>Voles</subject><issn>0022-3395</issn><issn>1937-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EKqUgdiQkDwimgB-x446ogoJUwUA7RzfuTWuUR7ETUP89qRIxMlyd4Xz3Gw4hl5zdC8mSBykMV4k-ImM-lUkkZKyOyZgxISIpp-qUnIXwyRhT3Y3ISAtmZDwdk9Ubtr62WyydhYJCtaZgG_ftmj21W6g2GKirqIfmkDnaBtf0xzVbuvT7HVR1qEugmW8tOjqHMnNYBTwnJzkUAS-GnJDV89Ny9hIt3uevs8dFZKWIm0gbyHJIRGw1ZAYSYCaRiHFmOILgFnNjTMaVZsbGholcZaCV7l44xFoIOSG3vXfn668WQ5OWLlgsCqiwbkNquGRKJqYD73rQ-joEj3m6864Ev085Sw8DpsOAHXk9KNusxPUfNyzW9Td9_xma2v-jueqxHOoUNt6FdPVhNNdacfkLKat-GA</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>Stibbs, H.H</creator><general>American Society of Parasitologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198406</creationdate><title>Neurochemical and activity changes in rats infected with Trypanosoma brucei Gambiense</title><author>Stibbs, H.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-68abfa724c6ab8a7a0873ee4b81ea21cef888b15608c4802f5ba656fa71a46223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Animals</topic><topic>BEHAVIOUR</topic><topic>BRAIN</topic><topic>Brain - metabolism</topic><topic>CATECHOLAMINE</topic><topic>CATECHOLAMINES</topic><topic>CATECOLAMINAS</topic><topic>Caudate Nucleus - metabolism</topic><topic>CEREBRO</topic><topic>COMPORTAMIENTO</topic><topic>COMPORTEMENT</topic><topic>DIHYDROXYPHENYLACETIC ACID</topic><topic>Dopamine - metabolism</topic><topic>ENCEPHALE</topic><topic>Experimental</topic><topic>Female</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>Infections</topic><topic>LOCOMOCION</topic><topic>LOCOMOTION</topic><topic>MEDICAMENT NEUROTROPE</topic><topic>MEDICAMENTOS NEUROTROPICOS</topic><topic>Medulla Oblongata - metabolism</topic><topic>Metabolism</topic><topic>Motor Activity</topic><topic>Nervous system diseases</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>NEUROTRANSMITTERS</topic><topic>NEUROTROPIC DRUGS</topic><topic>Parasitism</topic><topic>Parasitology</topic><topic>Pathology</topic><topic>Phenylacetates - metabolism</topic><topic>Pons - metabolism</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Inbred Strains</topic><topic>Serotonin - metabolism</topic><topic>TRYPANOSOMA</topic><topic>Trypanosoma brucei gambiense</topic><topic>TRYPANOSOMA GAMBIENSE</topic><topic>Trypanosomiasis</topic><topic>Trypanosomiasis, African - metabolism</topic><topic>Trypanosomiasis, African - physiopathology</topic><topic>Voles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stibbs, H.H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stibbs, H.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurochemical and activity changes in rats infected with Trypanosoma brucei Gambiense</atitle><jtitle>The Journal of parasitology</jtitle><addtitle>J Parasitol</addtitle><date>1984-06</date><risdate>1984</risdate><volume>70</volume><issue>3</issue><spage>428</spage><epage>432</epage><pages>428-432</pages><issn>0022-3395</issn><eissn>1937-2345</eissn><abstract>The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%. DOPAC levels declined by 30% in the caudate, but this change was significant at only P < 0.1. In the pons/medulla of infected rats the serotonin concentration dropped by 21% and the 5-HIAA concentration rose by 25%. Activity levels in infected rats decreased by 49% (gross movement) and 44% (total movement) relative to those of uninfected control rats.</abstract><cop>United States</cop><pub>American Society of Parasitologists</pub><pmid>6208349</pmid><doi>10.2307/3281576</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of parasitology, 1984-06, Vol.70 (3), p.428-432 |
| issn | 0022-3395 1937-2345 |
| language | eng |
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| source | MEDLINE; JSTOR |
| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Animals BEHAVIOUR BRAIN Brain - metabolism CATECHOLAMINE CATECHOLAMINES CATECOLAMINAS Caudate Nucleus - metabolism CEREBRO COMPORTAMIENTO COMPORTEMENT DIHYDROXYPHENYLACETIC ACID Dopamine - metabolism ENCEPHALE Experimental Female Hydroxyindoleacetic Acid - metabolism Infections LOCOMOCION LOCOMOTION MEDICAMENT NEUROTROPE MEDICAMENTOS NEUROTROPICOS Medulla Oblongata - metabolism Metabolism Motor Activity Nervous system diseases Neurotransmitter Agents - metabolism NEUROTRANSMITTERS NEUROTROPIC DRUGS Parasitism Parasitology Pathology Phenylacetates - metabolism Pons - metabolism RAT RATA RATS Rats, Inbred Strains Serotonin - metabolism TRYPANOSOMA Trypanosoma brucei gambiense TRYPANOSOMA GAMBIENSE Trypanosomiasis Trypanosomiasis, African - metabolism Trypanosomiasis, African - physiopathology Voles |
| title | Neurochemical and activity changes in rats infected with Trypanosoma brucei Gambiense |
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