Histomorphometric Study of the Enhancement of Renal Compensatory Hypertrophy by ACTH in the Rat
Summary In the female adult rat, renal compensatory hypertrophy is greatly enhanced by hyperadrenocorticism elicited by the administration of ACTH given at a dose of 18 Y/100 g BW/d for 7 days after uninephrectomy (UN). This renotrophic effect of ACTH is particularly prominent in rats drinking a NaC...
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| Veröffentlicht in: | Hormone and metabolic research 1984-07, Vol.16 (7), p.366-369 |
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| container_title | Hormone and metabolic research |
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| creator | Stephan, F. de Laharpe, F. Reville, P. Parmentier, C. Köll-Back, M. H. Turlot, J. Le Minor, J. Stahl, A. |
| description | Summary
In the female adult rat, renal compensatory hypertrophy is greatly enhanced by hyperadrenocorticism elicited by the administration of ACTH given at a dose of 18 Y/100 g BW/d for 7 days after uninephrectomy (UN). This renotrophic effect of ACTH is particularly prominent in rats drinking a NaCl solution (9 g/l). In the present experiments, we performed histomorphometrical measurements of the glomerular tuft (GT) and the proximal tubule (PT) in the hypertrophying kidney (HK) remaining 7 days after UN in 10 rats treated with ACTH and 7 control animals. The histologic preparations were examined under light microscropy with the “Kontron” image analyzer. ACTH increased the weight of the HK (1213.8 ± 20.3 mg versus 1037.3 ± 13.3, p < 0.001) and determined an enlargement of the cross sectional area of the GT (12559 ± 3351.3 μ
2
versus 10486 ± 407.5, p < 0.01) and of the epithelial area of the PT (1751 ± 40.8 μ
2
versus 1586 ± 41.5, p < 0.025). These morphometrical data are consistent with the increased Protein/DNA ratio - a marker of cellular hypertrophy - found in other rats studied under the same experimental conditions. The increased weight gain of the HK elicited by ACTH is related to the hypertrophy of the epithelial cells of the PT and possibly to an enlargement of the glomeruli. |
| doi_str_mv | 10.1055/s-2007-1014792 |
| format | Article |
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In the female adult rat, renal compensatory hypertrophy is greatly enhanced by hyperadrenocorticism elicited by the administration of ACTH given at a dose of 18 Y/100 g BW/d for 7 days after uninephrectomy (UN). This renotrophic effect of ACTH is particularly prominent in rats drinking a NaCl solution (9 g/l). In the present experiments, we performed histomorphometrical measurements of the glomerular tuft (GT) and the proximal tubule (PT) in the hypertrophying kidney (HK) remaining 7 days after UN in 10 rats treated with ACTH and 7 control animals. The histologic preparations were examined under light microscropy with the “Kontron” image analyzer. ACTH increased the weight of the HK (1213.8 ± 20.3 mg versus 1037.3 ± 13.3, p < 0.001) and determined an enlargement of the cross sectional area of the GT (12559 ± 3351.3 μ
2
versus 10486 ± 407.5, p < 0.01) and of the epithelial area of the PT (1751 ± 40.8 μ
2
versus 1586 ± 41.5, p < 0.025). These morphometrical data are consistent with the increased Protein/DNA ratio - a marker of cellular hypertrophy - found in other rats studied under the same experimental conditions. The increased weight gain of the HK elicited by ACTH is related to the hypertrophy of the epithelial cells of the PT and possibly to an enlargement of the glomeruli.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1014792</identifier><identifier>PMID: 6092252</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adrenocorticotropic Hormone - pharmacology ; Animals ; Biological and medical sciences ; Epithelium - pathology ; Female ; Hypertrophy - chemically induced ; Hypertrophy - pathology ; Kidney - drug effects ; Kidney - pathology ; Kidney Glomerulus - drug effects ; Kidney Glomerulus - pathology ; Kidney Tubules, Proximal - drug effects ; Kidney Tubules, Proximal - pathology ; Kidneys ; Medical sciences ; Nephrectomy ; Nephrology. Urinary tract diseases ; Organ Size - drug effects ; Originals ; Rats ; Rats, Inbred Strains ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Hormone and metabolic research, 1984-07, Vol.16 (7), p.366-369</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1014792.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3003,3004,27903,27904,54537</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8900342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6092252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stephan, F.</creatorcontrib><creatorcontrib>de Laharpe, F.</creatorcontrib><creatorcontrib>Reville, P.</creatorcontrib><creatorcontrib>Parmentier, C.</creatorcontrib><creatorcontrib>Köll-Back, M. H.</creatorcontrib><creatorcontrib>Turlot, J.</creatorcontrib><creatorcontrib>Le Minor, J.</creatorcontrib><creatorcontrib>Stahl, A.</creatorcontrib><title>Histomorphometric Study of the Enhancement of Renal Compensatory Hypertrophy by ACTH in the Rat</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
In the female adult rat, renal compensatory hypertrophy is greatly enhanced by hyperadrenocorticism elicited by the administration of ACTH given at a dose of 18 Y/100 g BW/d for 7 days after uninephrectomy (UN). This renotrophic effect of ACTH is particularly prominent in rats drinking a NaCl solution (9 g/l). In the present experiments, we performed histomorphometrical measurements of the glomerular tuft (GT) and the proximal tubule (PT) in the hypertrophying kidney (HK) remaining 7 days after UN in 10 rats treated with ACTH and 7 control animals. The histologic preparations were examined under light microscropy with the “Kontron” image analyzer. ACTH increased the weight of the HK (1213.8 ± 20.3 mg versus 1037.3 ± 13.3, p < 0.001) and determined an enlargement of the cross sectional area of the GT (12559 ± 3351.3 μ
2
versus 10486 ± 407.5, p < 0.01) and of the epithelial area of the PT (1751 ± 40.8 μ
2
versus 1586 ± 41.5, p < 0.025). These morphometrical data are consistent with the increased Protein/DNA ratio - a marker of cellular hypertrophy - found in other rats studied under the same experimental conditions. The increased weight gain of the HK elicited by ACTH is related to the hypertrophy of the epithelial cells of the PT and possibly to an enlargement of the glomeruli.</description><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Hypertrophy - chemically induced</subject><subject>Hypertrophy - pathology</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidney Glomerulus - drug effects</subject><subject>Kidney Glomerulus - pathology</subject><subject>Kidney Tubules, Proximal - drug effects</subject><subject>Kidney Tubules, Proximal - pathology</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Nephrectomy</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Organ Size - drug effects</subject><subject>Originals</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtv2zAQgImiReo4XbsV4FBkk8uXHhwNI40DGCiQJjNBk0dIgSSqJDXo31e2BW9BpsPdfffAh9B3SjaU5PmvmDFCyowSKkrJPqEVFVxmglXFZ7QihFZZTgT_im5jfJtTIam4QTcFkYzlbIXUvonJdz4Mte8ghcbgv2m0E_YOpxrwQ1_r3kAHfTqVnqHXLd75boA-6uTDhPfTACEFP9QTPk54u3vZ46Y_Dz_rdIe-ON1G-LbENXr9_fCy22eHP49Pu-0hM1zwlNH86IzlWgDk85OFLCpubXW0nFptaQVOGCM0K60DXlCQglkGxJaOlk4S4Gt0f9k7BP9vhJhU10QDbat78GNUFWUyz0v5IUgFYYycwc0FNMHHGMCpITSdDpOiRJ3Uq6hO6tWifh74sWwejx3YK764nvs_l76ORrcuzGKbeMUqSQgXJyy7YKluZu_qzY9hlh7fO_sfBlCZxA</recordid><startdate>198407</startdate><enddate>198407</enddate><creator>Stephan, F.</creator><creator>de Laharpe, F.</creator><creator>Reville, P.</creator><creator>Parmentier, C.</creator><creator>Köll-Back, M. H.</creator><creator>Turlot, J.</creator><creator>Le Minor, J.</creator><creator>Stahl, A.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SQ</scope><scope>7X8</scope></search><sort><creationdate>198407</creationdate><title>Histomorphometric Study of the Enhancement of Renal Compensatory Hypertrophy by ACTH in the Rat</title><author>Stephan, F. ; de Laharpe, F. ; Reville, P. ; Parmentier, C. ; Köll-Back, M. H. ; Turlot, J. ; Le Minor, J. ; Stahl, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-15bfcd3a4ee501469683dd8bd31dad18ef4cc4a27dfe361e942d2e0d7f17f90e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Hypertrophy - chemically induced</topic><topic>Hypertrophy - pathology</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidney Glomerulus - drug effects</topic><topic>Kidney Glomerulus - pathology</topic><topic>Kidney Tubules, Proximal - drug effects</topic><topic>Kidney Tubules, Proximal - pathology</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Nephrectomy</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Organ Size - drug effects</topic><topic>Originals</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stephan, F.</creatorcontrib><creatorcontrib>de Laharpe, F.</creatorcontrib><creatorcontrib>Reville, P.</creatorcontrib><creatorcontrib>Parmentier, C.</creatorcontrib><creatorcontrib>Köll-Back, M. H.</creatorcontrib><creatorcontrib>Turlot, J.</creatorcontrib><creatorcontrib>Le Minor, J.</creatorcontrib><creatorcontrib>Stahl, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Endocrinology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stephan, F.</au><au>de Laharpe, F.</au><au>Reville, P.</au><au>Parmentier, C.</au><au>Köll-Back, M. H.</au><au>Turlot, J.</au><au>Le Minor, J.</au><au>Stahl, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histomorphometric Study of the Enhancement of Renal Compensatory Hypertrophy by ACTH in the Rat</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1984-07</date><risdate>1984</risdate><volume>16</volume><issue>7</issue><spage>366</spage><epage>369</epage><pages>366-369</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
In the female adult rat, renal compensatory hypertrophy is greatly enhanced by hyperadrenocorticism elicited by the administration of ACTH given at a dose of 18 Y/100 g BW/d for 7 days after uninephrectomy (UN). This renotrophic effect of ACTH is particularly prominent in rats drinking a NaCl solution (9 g/l). In the present experiments, we performed histomorphometrical measurements of the glomerular tuft (GT) and the proximal tubule (PT) in the hypertrophying kidney (HK) remaining 7 days after UN in 10 rats treated with ACTH and 7 control animals. The histologic preparations were examined under light microscropy with the “Kontron” image analyzer. ACTH increased the weight of the HK (1213.8 ± 20.3 mg versus 1037.3 ± 13.3, p < 0.001) and determined an enlargement of the cross sectional area of the GT (12559 ± 3351.3 μ
2
versus 10486 ± 407.5, p < 0.01) and of the epithelial area of the PT (1751 ± 40.8 μ
2
versus 1586 ± 41.5, p < 0.025). These morphometrical data are consistent with the increased Protein/DNA ratio - a marker of cellular hypertrophy - found in other rats studied under the same experimental conditions. The increased weight gain of the HK elicited by ACTH is related to the hypertrophy of the epithelial cells of the PT and possibly to an enlargement of the glomeruli.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>6092252</pmid><doi>10.1055/s-2007-1014792</doi><tpages>4</tpages></addata></record> |
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| subjects | Adrenocorticotropic Hormone - pharmacology Animals Biological and medical sciences Epithelium - pathology Female Hypertrophy - chemically induced Hypertrophy - pathology Kidney - drug effects Kidney - pathology Kidney Glomerulus - drug effects Kidney Glomerulus - pathology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - pathology Kidneys Medical sciences Nephrectomy Nephrology. Urinary tract diseases Organ Size - drug effects Originals Rats Rats, Inbred Strains Urinary system involvement in other diseases. Miscellaneous |
| title | Histomorphometric Study of the Enhancement of Renal Compensatory Hypertrophy by ACTH in the Rat |
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