Ultrastructural localization of immunoglobulins in hairy cell leukemia
Neoplastic cells from 13 cases of hairy cell leukemia were investigated for immunoglobulin production and lysozyme activity by an electron-immunoperoxidase technique. In 10 cases cytoplasmic immunoglobulins were found, but lysozyme activity was absent in all cases. Immunoglobulins were detected in t...
Gespeichert in:
| Veröffentlicht in: | Human pathology 1984-11, Vol.15 (11), p.1042-1047 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1047 |
|---|---|
| container_issue | 11 |
| container_start_page | 1042 |
| container_title | Human pathology |
| container_volume | 15 |
| creator | Mori, Naoyoshi Tsunoda, Rikiya Kojima, Mizu Andres, Terry Kadin, Marshall E. |
| description | Neoplastic cells from 13 cases of hairy cell leukemia were investigated for immunoglobulin production and lysozyme activity by an electron-immunoperoxidase technique. In 10 cases cytoplasmic immunoglobulins were found, but lysozyme activity was absent in all cases. Immunoglobulins were detected in the perinuclear space and endoplasmic reticulum and at the surface of hairy cells. Of the cases in which immunoglobulins were detected in hairy cells, nine were positive with IgM antiserum and one with IgG antiserum. The immunoglobulins were monoclonal in all cases; six were positive with λ antiserum and three with κ antiserum. The class and type of surface immunoglobulins were identical to those of cytoplasmic immunoglobulins in the hairy cells. These results support the conclusion that hairy cells are commonly derived from immunoglobulin-producing B cells at an earlier stage of differentiation than plasma cells. |
| doi_str_mv | 10.1016/S0046-8177(84)80247-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81295011</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0046817784802476</els_id><sourcerecordid>81295011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-c5b182df45545bccc2378efde3f50cb4d0ee8127962afb7a033bf0fbbe7520c53</originalsourceid><addsrcrecordid>eNqFkE1LxDAURYMoOn78BKELEV1U89Gk6UpEHBUEF-o6JOmLRttGk1bQX2_GGWbr6i3euXk3B6FDgs8IJuL8EeNKlJLU9YmsTiWmVV2KDTQjnNFSsoZuotka2UG7Kb1hTAiv-DbaFhUTRIgZmj93Y9RpjJMdp6i7ogtWd_5Hjz4MRXCF7_tpCC9dMFPnh1T4oXjVPn4XFrpMw_QOvdf7aMvpLsHBau6h5_n109Vtef9wc3d1eV9aJpuxtNwQSVtX8VzDWGspqyW4Fpjj2JqqxQCS0LoRVDtTa8yYcdgZAzWn2HK2h46X737E8DlBGlXv06KJHiBMSeVww_MvM8iXoI0hpQhOfUTf6_itCFYLf-rPn1rIUbJSf_6UyLnD1YHJ9NCuUytheX-02uuURbmoB-vTGmswo7JeYBdLDLKMLw9RJethsND6CHZUbfD_FPkF-9aN7Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81295011</pqid></control><display><type>article</type><title>Ultrastructural localization of immunoglobulins in hairy cell leukemia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mori, Naoyoshi ; Tsunoda, Rikiya ; Kojima, Mizu ; Andres, Terry ; Kadin, Marshall E.</creator><creatorcontrib>Mori, Naoyoshi ; Tsunoda, Rikiya ; Kojima, Mizu ; Andres, Terry ; Kadin, Marshall E.</creatorcontrib><description>Neoplastic cells from 13 cases of hairy cell leukemia were investigated for immunoglobulin production and lysozyme activity by an electron-immunoperoxidase technique. In 10 cases cytoplasmic immunoglobulins were found, but lysozyme activity was absent in all cases. Immunoglobulins were detected in the perinuclear space and endoplasmic reticulum and at the surface of hairy cells. Of the cases in which immunoglobulins were detected in hairy cells, nine were positive with IgM antiserum and one with IgG antiserum. The immunoglobulins were monoclonal in all cases; six were positive with λ antiserum and three with κ antiserum. The class and type of surface immunoglobulins were identical to those of cytoplasmic immunoglobulins in the hairy cells. These results support the conclusion that hairy cells are commonly derived from immunoglobulin-producing B cells at an earlier stage of differentiation than plasma cells.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(84)80247-6</identifier><identifier>PMID: 6436166</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>B-Lymphocytes - immunology ; B-Lymphocytes - ultrastructure ; Biological and medical sciences ; Hematologic and hematopoietic diseases ; Humans ; Immunoenzyme Techniques ; Immunoglobulin gamma-Chains - isolation & purification ; Immunoglobulin kappa-Chains - isolation & purification ; Immunoglobulins - isolation & purification ; Leukemia, Hairy Cell - immunology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Microscopy, Electron ; Muramidase - isolation & purification ; Receptors, Antigen, B-Cell - isolation & purification</subject><ispartof>Human pathology, 1984-11, Vol.15 (11), p.1042-1047</ispartof><rights>1984 W. B. Saunders Co.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-c5b182df45545bccc2378efde3f50cb4d0ee8127962afb7a033bf0fbbe7520c53</citedby><cites>FETCH-LOGICAL-c389t-c5b182df45545bccc2378efde3f50cb4d0ee8127962afb7a033bf0fbbe7520c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817784802476$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9032876$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6436166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Naoyoshi</creatorcontrib><creatorcontrib>Tsunoda, Rikiya</creatorcontrib><creatorcontrib>Kojima, Mizu</creatorcontrib><creatorcontrib>Andres, Terry</creatorcontrib><creatorcontrib>Kadin, Marshall E.</creatorcontrib><title>Ultrastructural localization of immunoglobulins in hairy cell leukemia</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Neoplastic cells from 13 cases of hairy cell leukemia were investigated for immunoglobulin production and lysozyme activity by an electron-immunoperoxidase technique. In 10 cases cytoplasmic immunoglobulins were found, but lysozyme activity was absent in all cases. Immunoglobulins were detected in the perinuclear space and endoplasmic reticulum and at the surface of hairy cells. Of the cases in which immunoglobulins were detected in hairy cells, nine were positive with IgM antiserum and one with IgG antiserum. The immunoglobulins were monoclonal in all cases; six were positive with λ antiserum and three with κ antiserum. The class and type of surface immunoglobulins were identical to those of cytoplasmic immunoglobulins in the hairy cells. These results support the conclusion that hairy cells are commonly derived from immunoglobulin-producing B cells at an earlier stage of differentiation than plasma cells.</description><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulin gamma-Chains - isolation & purification</subject><subject>Immunoglobulin kappa-Chains - isolation & purification</subject><subject>Immunoglobulins - isolation & purification</subject><subject>Leukemia, Hairy Cell - immunology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Muramidase - isolation & purification</subject><subject>Receptors, Antigen, B-Cell - isolation & purification</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAURYMoOn78BKELEV1U89Gk6UpEHBUEF-o6JOmLRttGk1bQX2_GGWbr6i3euXk3B6FDgs8IJuL8EeNKlJLU9YmsTiWmVV2KDTQjnNFSsoZuotka2UG7Kb1hTAiv-DbaFhUTRIgZmj93Y9RpjJMdp6i7ogtWd_5Hjz4MRXCF7_tpCC9dMFPnh1T4oXjVPn4XFrpMw_QOvdf7aMvpLsHBau6h5_n109Vtef9wc3d1eV9aJpuxtNwQSVtX8VzDWGspqyW4Fpjj2JqqxQCS0LoRVDtTa8yYcdgZAzWn2HK2h46X737E8DlBGlXv06KJHiBMSeVww_MvM8iXoI0hpQhOfUTf6_itCFYLf-rPn1rIUbJSf_6UyLnD1YHJ9NCuUytheX-02uuURbmoB-vTGmswo7JeYBdLDLKMLw9RJethsND6CHZUbfD_FPkF-9aN7Q</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>Mori, Naoyoshi</creator><creator>Tsunoda, Rikiya</creator><creator>Kojima, Mizu</creator><creator>Andres, Terry</creator><creator>Kadin, Marshall E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Ultrastructural localization of immunoglobulins in hairy cell leukemia</title><author>Mori, Naoyoshi ; Tsunoda, Rikiya ; Kojima, Mizu ; Andres, Terry ; Kadin, Marshall E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-c5b182df45545bccc2378efde3f50cb4d0ee8127962afb7a033bf0fbbe7520c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulin gamma-Chains - isolation & purification</topic><topic>Immunoglobulin kappa-Chains - isolation & purification</topic><topic>Immunoglobulins - isolation & purification</topic><topic>Leukemia, Hairy Cell - immunology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Muramidase - isolation & purification</topic><topic>Receptors, Antigen, B-Cell - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Naoyoshi</creatorcontrib><creatorcontrib>Tsunoda, Rikiya</creatorcontrib><creatorcontrib>Kojima, Mizu</creatorcontrib><creatorcontrib>Andres, Terry</creatorcontrib><creatorcontrib>Kadin, Marshall E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Naoyoshi</au><au>Tsunoda, Rikiya</au><au>Kojima, Mizu</au><au>Andres, Terry</au><au>Kadin, Marshall E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural localization of immunoglobulins in hairy cell leukemia</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1984-11</date><risdate>1984</risdate><volume>15</volume><issue>11</issue><spage>1042</spage><epage>1047</epage><pages>1042-1047</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Neoplastic cells from 13 cases of hairy cell leukemia were investigated for immunoglobulin production and lysozyme activity by an electron-immunoperoxidase technique. In 10 cases cytoplasmic immunoglobulins were found, but lysozyme activity was absent in all cases. Immunoglobulins were detected in the perinuclear space and endoplasmic reticulum and at the surface of hairy cells. Of the cases in which immunoglobulins were detected in hairy cells, nine were positive with IgM antiserum and one with IgG antiserum. The immunoglobulins were monoclonal in all cases; six were positive with λ antiserum and three with κ antiserum. The class and type of surface immunoglobulins were identical to those of cytoplasmic immunoglobulins in the hairy cells. These results support the conclusion that hairy cells are commonly derived from immunoglobulin-producing B cells at an earlier stage of differentiation than plasma cells.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6436166</pmid><doi>10.1016/S0046-8177(84)80247-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 1984-11, Vol.15 (11), p.1042-1047 |
| issn | 0046-8177 1532-8392 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81295011 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | B-Lymphocytes - immunology B-Lymphocytes - ultrastructure Biological and medical sciences Hematologic and hematopoietic diseases Humans Immunoenzyme Techniques Immunoglobulin gamma-Chains - isolation & purification Immunoglobulin kappa-Chains - isolation & purification Immunoglobulins - isolation & purification Leukemia, Hairy Cell - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Microscopy, Electron Muramidase - isolation & purification Receptors, Antigen, B-Cell - isolation & purification |
| title | Ultrastructural localization of immunoglobulins in hairy cell leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T16%3A53%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ultrastructural%20localization%20of%20immunoglobulins%20in%20hairy%20cell%20leukemia&rft.jtitle=Human%20pathology&rft.au=Mori,%20Naoyoshi&rft.date=1984-11&rft.volume=15&rft.issue=11&rft.spage=1042&rft.epage=1047&rft.pages=1042-1047&rft.issn=0046-8177&rft.eissn=1532-8392&rft.coden=HPCQA4&rft_id=info:doi/10.1016/S0046-8177(84)80247-6&rft_dat=%3Cproquest_cross%3E81295011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81295011&rft_id=info:pmid/6436166&rft_els_id=S0046817784802476&rfr_iscdi=true |