Intravenous versus intracoronary streptokinase for acute transmural myocardial infarction
In order to compare the thrombolytic efficacy of selective versus systemic administration of streptokinase, we gave this drug by either the intracoronary or intravenous routes to 25 patients during the first 6 hours of acute myocardial infarction. All patients had total occlusion of the infarct‐rela...
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| Veröffentlicht in: | Catheterization and cardiovascular diagnosis 1984, Vol.10 (4), p.319-327 |
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| container_title | Catheterization and cardiovascular diagnosis |
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| creator | Blunda, Michael Meister, Steven G. Shechter, Jay A. Pickering, Nancy J. Wolf, Nelson M. |
| description | In order to compare the thrombolytic efficacy of selective versus systemic administration of streptokinase, we gave this drug by either the intracoronary or intravenous routes to 25 patients during the first 6 hours of acute myocardial infarction. All patients had total occlusion of the infarct‐related vessel, unresponsive to intracoronary nitroglycerin. Twelve patients received intravenous streptokinase and 13 received intracoronary administration of the drug. Angiograms were taken prior to and during streptokinase administration. Reopening was achieved in 11 of 13 intracoronary patients and 8 of 12 intravenous patients (P = Ns). Time to reopening was longer (54 minutes) in the intravenous patients than in the intracoronary patients (26 minutes) (P < 0.05). In this study, intravenous streptokinase reopened infarct‐related vessels nearly as often as intracoronary streptokinase, but it took longer. Given the limited access and time to prepare for intracoronary infusion and the ease of intravenous administration, further study of intravenous streptokinase is justified. |
| doi_str_mv | 10.1002/ccd.1810100403 |
| format | Article |
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All patients had total occlusion of the infarct‐related vessel, unresponsive to intracoronary nitroglycerin. Twelve patients received intravenous streptokinase and 13 received intracoronary administration of the drug. Angiograms were taken prior to and during streptokinase administration. Reopening was achieved in 11 of 13 intracoronary patients and 8 of 12 intravenous patients (P = Ns). Time to reopening was longer (54 minutes) in the intravenous patients than in the intracoronary patients (26 minutes) (P < 0.05). In this study, intravenous streptokinase reopened infarct‐related vessels nearly as often as intracoronary streptokinase, but it took longer. Given the limited access and time to prepare for intracoronary infusion and the ease of intravenous administration, further study of intravenous streptokinase is justified.</description><identifier>ISSN: 0098-6569</identifier><identifier>EISSN: 1097-0304</identifier><identifier>DOI: 10.1002/ccd.1810100403</identifier><identifier>PMID: 6488304</identifier><identifier>CODEN: CCDIDC</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Circulation - drug effects ; Coronary heart disease ; Coronary Vessels - drug effects ; Electrocardiography ; Female ; Heart ; Humans ; Infusions, Parenteral ; Injections ; intravenous therapy ; Male ; Medical sciences ; Middle Aged ; myocardial infarction ; Myocardial Infarction - drug therapy ; streptokinase ; Streptokinase - administration & dosage ; Streptokinase - therapeutic use ; thrombolysis</subject><ispartof>Catheterization and cardiovascular diagnosis, 1984, Vol.10 (4), p.319-327</ispartof><rights>Copyright © 1984 John Wiley & Sons, Ltd.</rights><rights>1985 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4073-904f56e271346d6470e133e4cc4c761d5af457c89d94064a4035a4aca966d943</citedby><cites>FETCH-LOGICAL-c4073-904f56e271346d6470e133e4cc4c761d5af457c89d94064a4035a4aca966d943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.1810100403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.1810100403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8882532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6488304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blunda, Michael</creatorcontrib><creatorcontrib>Meister, Steven G.</creatorcontrib><creatorcontrib>Shechter, Jay A.</creatorcontrib><creatorcontrib>Pickering, Nancy J.</creatorcontrib><creatorcontrib>Wolf, Nelson M.</creatorcontrib><title>Intravenous versus intracoronary streptokinase for acute transmural myocardial infarction</title><title>Catheterization and cardiovascular diagnosis</title><addtitle>Cathet. Cardiovasc. Diagn</addtitle><description>In order to compare the thrombolytic efficacy of selective versus systemic administration of streptokinase, we gave this drug by either the intracoronary or intravenous routes to 25 patients during the first 6 hours of acute myocardial infarction. All patients had total occlusion of the infarct‐related vessel, unresponsive to intracoronary nitroglycerin. Twelve patients received intravenous streptokinase and 13 received intracoronary administration of the drug. Angiograms were taken prior to and during streptokinase administration. Reopening was achieved in 11 of 13 intracoronary patients and 8 of 12 intravenous patients (P = Ns). Time to reopening was longer (54 minutes) in the intravenous patients than in the intracoronary patients (26 minutes) (P < 0.05). In this study, intravenous streptokinase reopened infarct‐related vessels nearly as often as intracoronary streptokinase, but it took longer. Given the limited access and time to prepare for intracoronary infusion and the ease of intravenous administration, further study of intravenous streptokinase is justified.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - drug effects</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Infusions, Parenteral</subject><subject>Injections</subject><subject>intravenous therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - drug therapy</subject><subject>streptokinase</subject><subject>Streptokinase - administration & dosage</subject><subject>Streptokinase - therapeutic use</subject><subject>thrombolysis</subject><issn>0098-6569</issn><issn>1097-0304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1P3DAQxS0EolvKtbdKOaDesoxjxx_HdgsUCYGQVqCerKnjSC5JvLWThf3vMdrVop56Gnvm98Z-j5DPFOYUoDq3tplTRSFfOLADMqOgZQkM-CGZAWhVilroD-RjSn8gM4LxY3IsuFIZmZFf18MYce2GMKVi7WLKxb-1bIhhwLgp0hjdagxPfsDkijbEAu00uiIzQ-qniF3Rb4LF2Ph89EOL0Y4-DJ_IUYtdcqe7ekKWlxfLxc_y5u7qevHtprQcJCs18LYWrpKUcdEILsFRxhy3llspaFNjy2tplW40B8Exm6yRo0UtRG6xE_J1u3YVw9_JpdH0PlnXdTi47MkoWmmQXGZwvgVtDClF15pV9H12aCiYtyhNjtK8R5kFX3abp9-9a_b4Lrs8P9vNMVns2pyH9WmPKaWqmlUZ01vs2Xdu859HzWLx458vlFutT6N72WsxPhkhmazN4-2VWT7W3x_Ew725Za_xZZyh</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Blunda, Michael</creator><creator>Meister, Steven G.</creator><creator>Shechter, Jay A.</creator><creator>Pickering, Nancy J.</creator><creator>Wolf, Nelson M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Intravenous versus intracoronary streptokinase for acute transmural myocardial infarction</title><author>Blunda, Michael ; Meister, Steven G. ; Shechter, Jay A. ; Pickering, Nancy J. ; Wolf, Nelson M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4073-904f56e271346d6470e133e4cc4c761d5af457c89d94064a4035a4aca966d943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - drug effects</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Infusions, Parenteral</topic><topic>Injections</topic><topic>intravenous therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - drug therapy</topic><topic>streptokinase</topic><topic>Streptokinase - administration & dosage</topic><topic>Streptokinase - therapeutic use</topic><topic>thrombolysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Blunda, Michael</creatorcontrib><creatorcontrib>Meister, Steven G.</creatorcontrib><creatorcontrib>Shechter, Jay A.</creatorcontrib><creatorcontrib>Pickering, Nancy J.</creatorcontrib><creatorcontrib>Wolf, Nelson M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blunda, Michael</au><au>Meister, Steven G.</au><au>Shechter, Jay A.</au><au>Pickering, Nancy J.</au><au>Wolf, Nelson M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous versus intracoronary streptokinase for acute transmural myocardial infarction</atitle><jtitle>Catheterization and cardiovascular diagnosis</jtitle><addtitle>Cathet. Cardiovasc. Diagn</addtitle><date>1984</date><risdate>1984</risdate><volume>10</volume><issue>4</issue><spage>319</spage><epage>327</epage><pages>319-327</pages><issn>0098-6569</issn><eissn>1097-0304</eissn><coden>CCDIDC</coden><abstract>In order to compare the thrombolytic efficacy of selective versus systemic administration of streptokinase, we gave this drug by either the intracoronary or intravenous routes to 25 patients during the first 6 hours of acute myocardial infarction. All patients had total occlusion of the infarct‐related vessel, unresponsive to intracoronary nitroglycerin. Twelve patients received intravenous streptokinase and 13 received intracoronary administration of the drug. Angiograms were taken prior to and during streptokinase administration. Reopening was achieved in 11 of 13 intracoronary patients and 8 of 12 intravenous patients (P = Ns). Time to reopening was longer (54 minutes) in the intravenous patients than in the intracoronary patients (26 minutes) (P < 0.05). In this study, intravenous streptokinase reopened infarct‐related vessels nearly as often as intracoronary streptokinase, but it took longer. Given the limited access and time to prepare for intracoronary infusion and the ease of intravenous administration, further study of intravenous streptokinase is justified.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6488304</pmid><doi>10.1002/ccd.1810100403</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cardiology. Vascular system Coronary Circulation - drug effects Coronary heart disease Coronary Vessels - drug effects Electrocardiography Female Heart Humans Infusions, Parenteral Injections intravenous therapy Male Medical sciences Middle Aged myocardial infarction Myocardial Infarction - drug therapy streptokinase Streptokinase - administration & dosage Streptokinase - therapeutic use thrombolysis |
| title | Intravenous versus intracoronary streptokinase for acute transmural myocardial infarction |
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