Metabolic activation of 1-naphthol by rat liver microsomes to 1,4-naphthoquinone and covalent binding species

1-Naphthol was metabolized by rat liver microsomes, in the presence of an NADPH-generating system, both to methanol-soluble metabolites including 1, 4-naphthoquinone and an uncharacterized product(s) (X) and also to covalently bound products. NADH was much less effective as an electron donor than NA...

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