Immune response in a symptomatic case of Tetrapetalonema perstans infection
The immune response in a 49-year-old Italian nun affected by Tetrapetalomena (Dipetalonema) perstans following an eight-year stay in Cameroon is reported. On admission the patient presented with polyarthralgia, conjunctival pruritus and irritation, oedema of the limbs, generalized itching, hypereosi...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1984, Vol.78 (4), p.489-491 |
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| container_issue | 4 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| container_volume | 78 |
| creator | Almaviva, M. Galli, M. Rizzi, M. Simonelli, E. Negri, C. Vigevani, G.M. |
| description | The immune response in a 49-year-old Italian nun affected by
Tetrapetalomena (Dipetalonema) perstans following an eight-year stay in Cameroon is reported. On admission the patient presented with polyarthralgia, conjunctival pruritus and irritation, oedema of the limbs, generalized itching, hypereosinophilia and low total IgE titre. During diethylcarbamazine treatment and, subsequently, during mebendazole administration, an exacerbation of her symptoms was observed. At the same time, activation of the alternative complement pathway and the appearance of circulating immune complexes were noted, suggesting a type III hypersensitivity reaction. Circulating immune complexes and diethylcarbamazine-induced release of parasitic antigens may also be considered responsible for the decrease of OKT3 and OKT4 positive lymphocytes. |
| doi_str_mv | 10.1016/0035-9203(84)90069-5 |
| format | Article |
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Tetrapetalomena (Dipetalonema) perstans following an eight-year stay in Cameroon is reported. On admission the patient presented with polyarthralgia, conjunctival pruritus and irritation, oedema of the limbs, generalized itching, hypereosinophilia and low total IgE titre. During diethylcarbamazine treatment and, subsequently, during mebendazole administration, an exacerbation of her symptoms was observed. At the same time, activation of the alternative complement pathway and the appearance of circulating immune complexes were noted, suggesting a type III hypersensitivity reaction. Circulating immune complexes and diethylcarbamazine-induced release of parasitic antigens may also be considered responsible for the decrease of OKT3 and OKT4 positive lymphocytes.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/0035-9203(84)90069-5</identifier><identifier>PMID: 6541380</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Antibody Formation ; Biological and medical sciences ; Cameroon ; Diethylcarbamazine - therapeutic use ; Dipetalonema Infections - drug therapy ; Dipetalonema Infections - immunology ; Diseases caused by nematodes ; Female ; Filariases ; Filariasis - immunology ; Helminthic diseases ; Humans ; Immunoglobulin E - biosynthesis ; Infectious diseases ; Mebendazole - therapeutic use ; Medical sciences ; Middle Aged ; Miscellaneous ; Parasitic diseases ; Tropical medicine</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Vol.78 (4), p.489-491</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-8849f887f31aed91a2cc8c0bf25e6f48ff66241fa8f1ae34133c4be931be35193</citedby><cites>FETCH-LOGICAL-c424t-8849f887f31aed91a2cc8c0bf25e6f48ff66241fa8f1ae34133c4be931be35193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9690153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6541380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almaviva, M.</creatorcontrib><creatorcontrib>Galli, M.</creatorcontrib><creatorcontrib>Rizzi, M.</creatorcontrib><creatorcontrib>Simonelli, E.</creatorcontrib><creatorcontrib>Negri, C.</creatorcontrib><creatorcontrib>Vigevani, G.M.</creatorcontrib><title>Immune response in a symptomatic case of Tetrapetalonema perstans infection</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>The immune response in a 49-year-old Italian nun affected by
Tetrapetalomena (Dipetalonema) perstans following an eight-year stay in Cameroon is reported. On admission the patient presented with polyarthralgia, conjunctival pruritus and irritation, oedema of the limbs, generalized itching, hypereosinophilia and low total IgE titre. During diethylcarbamazine treatment and, subsequently, during mebendazole administration, an exacerbation of her symptoms was observed. At the same time, activation of the alternative complement pathway and the appearance of circulating immune complexes were noted, suggesting a type III hypersensitivity reaction. Circulating immune complexes and diethylcarbamazine-induced release of parasitic antigens may also be considered responsible for the decrease of OKT3 and OKT4 positive lymphocytes.</description><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Cameroon</subject><subject>Diethylcarbamazine - therapeutic use</subject><subject>Dipetalonema Infections - drug therapy</subject><subject>Dipetalonema Infections - immunology</subject><subject>Diseases caused by nematodes</subject><subject>Female</subject><subject>Filariases</subject><subject>Filariasis - immunology</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Infectious diseases</subject><subject>Mebendazole - therapeutic use</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Parasitic diseases</subject><subject>Tropical medicine</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrFDEUx0NR6lr9BgpzEKmHaZNJMptcCrVot1iqh1qKl5DNvkB0JpnmZUv77c26yx49PXj_3__x-BHyjtETRll_SimXre4oP1bik6a01608IDOm5qrlkvIXZLZHXpHXiL8p7SST-pAc9lIwruiMfLsax3WEJgNOKSI0ITa2wedxKmm0JbjG2bpNvrmFku0ExQ4pwmibCTIWG7E2PLgSUnxDXno7ILzdzSPy8-uX24tFe_398uri_Lp1ohOlVUpor9Tcc2ZhpZntnFOOLn0nofdCed_3nWDeKl8BXh_lTixBc7YELpnmR-Tj9u6U08MasJgxoINhsBHSGo1inRKSbkCxBV1OiBm8mXIYbX42jJqNQ7MRZDaCjBLmn0Mja-397v56OcJqX9pJq_mHXW7R2cFnG13APaZ7TZnkFWu3WMACT_vY5j-mn_O5NIv7X-bzj0V3c8fuzGXlz7Y8VHePAbJBFyA6WIVcBZtVCv__-y_sWZyp</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Almaviva, M.</creator><creator>Galli, M.</creator><creator>Rizzi, M.</creator><creator>Simonelli, E.</creator><creator>Negri, C.</creator><creator>Vigevani, G.M.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Elsevier</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Immune response in a symptomatic case of Tetrapetalonema perstans infection</title><author>Almaviva, M. ; Galli, M. ; Rizzi, M. ; Simonelli, E. ; Negri, C. ; Vigevani, G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-8849f887f31aed91a2cc8c0bf25e6f48ff66241fa8f1ae34133c4be931be35193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Cameroon</topic><topic>Diethylcarbamazine - therapeutic use</topic><topic>Dipetalonema Infections - drug therapy</topic><topic>Dipetalonema Infections - immunology</topic><topic>Diseases caused by nematodes</topic><topic>Female</topic><topic>Filariases</topic><topic>Filariasis - immunology</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Infectious diseases</topic><topic>Mebendazole - therapeutic use</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Parasitic diseases</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almaviva, M.</creatorcontrib><creatorcontrib>Galli, M.</creatorcontrib><creatorcontrib>Rizzi, M.</creatorcontrib><creatorcontrib>Simonelli, E.</creatorcontrib><creatorcontrib>Negri, C.</creatorcontrib><creatorcontrib>Vigevani, G.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almaviva, M.</au><au>Galli, M.</au><au>Rizzi, M.</au><au>Simonelli, E.</au><au>Negri, C.</au><au>Vigevani, G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune response in a symptomatic case of Tetrapetalonema perstans infection</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1984</date><risdate>1984</risdate><volume>78</volume><issue>4</issue><spage>489</spage><epage>491</epage><pages>489-491</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>The immune response in a 49-year-old Italian nun affected by
Tetrapetalomena (Dipetalonema) perstans following an eight-year stay in Cameroon is reported. On admission the patient presented with polyarthralgia, conjunctival pruritus and irritation, oedema of the limbs, generalized itching, hypereosinophilia and low total IgE titre. During diethylcarbamazine treatment and, subsequently, during mebendazole administration, an exacerbation of her symptoms was observed. At the same time, activation of the alternative complement pathway and the appearance of circulating immune complexes were noted, suggesting a type III hypersensitivity reaction. Circulating immune complexes and diethylcarbamazine-induced release of parasitic antigens may also be considered responsible for the decrease of OKT3 and OKT4 positive lymphocytes.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>6541380</pmid><doi>10.1016/0035-9203(84)90069-5</doi><tpages>3</tpages></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Vol.78 (4), p.489-491 |
| issn | 0035-9203 1878-3503 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibody Formation Biological and medical sciences Cameroon Diethylcarbamazine - therapeutic use Dipetalonema Infections - drug therapy Dipetalonema Infections - immunology Diseases caused by nematodes Female Filariases Filariasis - immunology Helminthic diseases Humans Immunoglobulin E - biosynthesis Infectious diseases Mebendazole - therapeutic use Medical sciences Middle Aged Miscellaneous Parasitic diseases Tropical medicine |
| title | Immune response in a symptomatic case of Tetrapetalonema perstans infection |
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