Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels
The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release lev...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 1984-01, Vol.326 (4), p.287-290 |
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| container_issue | 4 |
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| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
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| creator | MOCAER-CRETET, E PRIOUX-GUYONNEAU, M REDJIMI, F COHEN, Y JACQUOT, C |
| description | The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. These effects, revealed by hypoxia, are related to other peripheral and central properties of this drug. |
| doi_str_mv | 10.1007/BF00501431 |
| format | Article |
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The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. 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The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. These effects, revealed by hypoxia, are related to other peripheral and central properties of this drug.</description><subject>Alkaloids - pharmacology</subject><subject>Altitude</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Fenclonine - pharmacology</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hypothalamus - metabolism</subject><subject>Hypoxia - metabolism</subject><subject>Ibogaine - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Serotonin - metabolism</subject><subject>Space life sciences</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1LBDEQxYMoep429kIKsRBW87mXlCp-gWCj9ZJNJl5kLzmTvUP_eyMeWgrDDMz78Yr3EDqi5JwSMru4uiVEEio43UKTelhDNWXbaEIIUw1lWu2h_VLeCCEtlXIX7baMz1grJyjcrIODaAH7lLGJdUbzmmIoY7DY2DGkiJPHo-khxyrOQwRcf_PPZfoIpgnRrSw4bOcmvkLBIeI-m7oL5DRWo4gHWMNQDtCON0OBw82dopfbm-fr--bx6e7h-vKxsVywsfFSS6tmIEEJcK5VVgjrqJcKHAgJPTe9U0773oreE86sADLj1FllWqM9n6LTH99lTu8rKGO3CMXCMJgIaVU6RZkSoqb0H0i51lLVpKbo7Ae0OZWSwXfLHBYmf3aUdN8FdH8FVPh447rqF-B-0U3iVT_Z6KZYM_hsog3lF9OEa0kp_wJobI7h</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>MOCAER-CRETET, E</creator><creator>PRIOUX-GUYONNEAU, M</creator><creator>REDJIMI, F</creator><creator>COHEN, Y</creator><creator>JACQUOT, C</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels</title><author>MOCAER-CRETET, E ; PRIOUX-GUYONNEAU, M ; REDJIMI, F ; COHEN, Y ; JACQUOT, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-f595c87e5e84edd68c44cd1f58ede45eb3abd8d9fbc4bf032c4e0731dc8a6a9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Alkaloids - pharmacology</topic><topic>Altitude</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Fenclonine - pharmacology</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hypothalamus - metabolism</topic><topic>Hypoxia - metabolism</topic><topic>Ibogaine - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Serotonin - metabolism</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOCAER-CRETET, E</creatorcontrib><creatorcontrib>PRIOUX-GUYONNEAU, M</creatorcontrib><creatorcontrib>REDJIMI, F</creatorcontrib><creatorcontrib>COHEN, Y</creatorcontrib><creatorcontrib>JACQUOT, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOCAER-CRETET, E</au><au>PRIOUX-GUYONNEAU, M</au><au>REDJIMI, F</au><au>COHEN, Y</au><au>JACQUOT, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>326</volume><issue>4</issue><spage>287</spage><epage>290</epage><pages>287-290</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><coden>NSAPCC</coden><abstract>The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. These effects, revealed by hypoxia, are related to other peripheral and central properties of this drug.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>6237265</pmid><doi>10.1007/BF00501431</doi><tpages>4</tpages></addata></record> |
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| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 1984-01, Vol.326 (4), p.287-290 |
| issn | 0028-1298 1432-1912 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Alkaloids - pharmacology Altitude Animals Biological and medical sciences Brain - metabolism Corpus Striatum - metabolism Fenclonine - pharmacology General and cellular metabolism. Vitamins Hypothalamus - metabolism Hypoxia - metabolism Ibogaine - pharmacology Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Serotonin - metabolism Space life sciences |
| title | Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels |
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