Calcitriol, Calcium, and Granulomatous Disease

Hypercalcemia is known to occur among patients with several granulomatous diseases, including sarcoidosis, 1 tuberculosis, 2 berylliosis, 3 and coccidioidomycosis. 4 Hypercalciuria may occur even more commonly and can contribute to the development of kidney stones. In this issue of the Journal , thi...

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Veröffentlicht in:The New England journal of medicine 1984-10, Vol.311 (17), p.1115-1117
Hauptverfasser: Lemann, Jacob, Gray, Richard W
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container_title The New England journal of medicine
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creator Lemann, Jacob
Gray, Richard W
description Hypercalcemia is known to occur among patients with several granulomatous diseases, including sarcoidosis, 1 tuberculosis, 2 berylliosis, 3 and coccidioidomycosis. 4 Hypercalciuria may occur even more commonly and can contribute to the development of kidney stones. In this issue of the Journal , this list of granulomatous disorders is extended with the report of hypercalcemia, hypercalciuria, and nephrolithiasis in association with granulomatous inflammation induced by silicone that was injected subcutaneously for cosmetic purposes. 5 Hypercalcemia in patients with sarcoidosis was shown in 1956 to be accompanied by augmented intestinal calcium absorption, the classic biologic effect of vitamin D. 6 Subsequently, elevated serum levels of the active . . .
doi_str_mv 10.1056/NEJM198410253111710
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subjects Calcitriol
Calcitriol - metabolism
Calcium
Calcium - metabolism
Cholecalciferol - metabolism
Dialysis
Dietary intake
Dihydroxycholecalciferols - blood
Disease
Granuloma - metabolism
Humans
Hypercalcemia - etiology
Metabolism
Metabolites
Pathogenesis
Patients
Sarcoidosis
Vitamin D
title Calcitriol, Calcium, and Granulomatous Disease
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