The hypothermic effect of 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl (CGP 6085 A) in wistar Kyoto rats

CGP 6085 A [4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl], a reported serotonin uptake and MAO (16) inhibitor, is a potent hypothermic agent. The hypothermic action of CGP 6085 A is dose dependent with a maximal reduction in rectal core temperature of greater than 1°C within one hour after drug ad...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Life sciences (1973) 1984-09, Vol.35 (12), p.1329-1335
Hauptverfasser:	Kulakowski, Elliott C., Hurst, Jeffrey H., Miller, Tom, Linnoila, Markku, Lovenberg, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines - pharmacology Animals Body Temperature - drug effects Dose-Response Relationship, Drug Fenclonine - pharmacology Hypothalamus - metabolism Kinetics Male Piperidines - pharmacology Rats Rats, Inbred Strains Serotonin - physiology Serotonin Antagonists - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!