Epstein–Barr-Virus Induced Lymphoproliferation: Implications for Antiviral Chemotherapy
EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative syndrome, 1 , 2 recipients of renal, 3 bone-marrow, 4...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 1984-11, Vol.311 (18), p.1163-1167 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1167 |
|---|---|
| container_issue | 18 |
| container_start_page | 1163 |
| container_title | The New England journal of medicine |
| container_volume | 311 |
| creator | Sullivan, John L Medveczky, Peter Forman, Stephen J Baker, Sharon M Monroe, James E Mulder, Carel |
| description | EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative syndrome,
1
,
2
recipients of renal,
3
bone-marrow,
4
or cardiac transplants,
5
and patients with severe combined immunodeficiency,
6
ataxia telangiectasia,
7
or the acquired immunodeficiency syndrome
8
have had fatal EBV-induced lymphoproliferative disorders. Infrequently, normal persons may die of EBV-induced lymphoproliferative disorders
9
including those of the central nervous system.
10
Treatment of these disorders has not been particularly successful, and antiviral agents are being investigated.
One such agent, acyclovir (9-[2-hydroxyethoxy-methyl] guanine) was recently found to be . . . |
| doi_str_mv | 10.1056/NEJM198411013111806 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81274649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81274649</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-88581b30f1cda6bc53dacd2bf546ac2ff4983e46d837538d4922a9f03c88e3003</originalsourceid><addsrcrecordid>eNp9kLtOAzEQRS0ECiHwBQgJCUSDFuz1Y-0SogBBARqgtbx-iI32EezdIh3_wB_yJThklQIhZoop5sy9owvAIYIXCFJ2-Ti5f0CCE4QgwgghDtkWGCKKcUIIZNtgCGHKE5IJvAv2QpjDWIiIARgwKGKzIYCTRWhtUX99fF4r75PXwnfheFqbTltzPFtWi7dm4ZuycNartmjqfbDjVBnsQT9H4OVm8jy-S2ZPt9Px1SzRmOA24ZxylGPokDaK5Zpio7RJc0cJUzp1jgiOLWGG44xibohIUyUcxJpziyHEI3C21o3u750NrayKoG1Zqto2XZAcpRlhRETw5Bc4bzpfx98k4lkUT6lYyeE1pX0TgrdOLnxRKb-UCMpVmvKPNOPVUa_d5ZU1m5s-vrg_7fcqaFU6r2pdhA3GuaDZj_n5GquqIGs7r_41_QZejod8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1877532590</pqid></control><display><type>article</type><title>Epstein–Barr-Virus Induced Lymphoproliferation: Implications for Antiviral Chemotherapy</title><source>MEDLINE</source><source>ProQuest Central UK/Ireland</source><creator>Sullivan, John L ; Medveczky, Peter ; Forman, Stephen J ; Baker, Sharon M ; Monroe, James E ; Mulder, Carel</creator><creatorcontrib>Sullivan, John L ; Medveczky, Peter ; Forman, Stephen J ; Baker, Sharon M ; Monroe, James E ; Mulder, Carel</creatorcontrib><description>EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative syndrome,
1
,
2
recipients of renal,
3
bone-marrow,
4
or cardiac transplants,
5
and patients with severe combined immunodeficiency,
6
ataxia telangiectasia,
7
or the acquired immunodeficiency syndrome
8
have had fatal EBV-induced lymphoproliferative disorders. Infrequently, normal persons may die of EBV-induced lymphoproliferative disorders
9
including those of the central nervous system.
10
Treatment of these disorders has not been particularly successful, and antiviral agents are being investigated.
One such agent, acyclovir (9-[2-hydroxyethoxy-methyl] guanine) was recently found to be . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198411013111806</identifier><identifier>PMID: 6090906</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Acyclovir - therapeutic use ; Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibodies, Viral - analysis ; Antigens ; Antiviral agents ; Biological and medical sciences ; Case reports ; Child ; Deoxyribonucleic acid ; DNA ; DNA, Viral - analysis ; Electrophoresis, Agar Gel ; Epstein-Barr virus ; Female ; Genes, Viral ; Genomes ; Herpesviridae Infections - drug therapy ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - immunology ; Humans ; Immunoglobulins ; Infections ; Liver ; Lymphatic system ; Lymphocytes ; Lymphoproliferative Disorders - drug therapy ; Male ; Medical sciences ; Nucleic Acid Hybridization ; Pediatrics ; Pharmacology. Drug treatments ; Spleen ; Transplants & implants ; Virus Replication - drug effects</subject><ispartof>The New England journal of medicine, 1984-11, Vol.311 (18), p.1163-1167</ispartof><rights>1985 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Nov 1, 1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-88581b30f1cda6bc53dacd2bf546ac2ff4983e46d837538d4922a9f03c88e3003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1877532590?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8895790$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6090906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sullivan, John L</creatorcontrib><creatorcontrib>Medveczky, Peter</creatorcontrib><creatorcontrib>Forman, Stephen J</creatorcontrib><creatorcontrib>Baker, Sharon M</creatorcontrib><creatorcontrib>Monroe, James E</creatorcontrib><creatorcontrib>Mulder, Carel</creatorcontrib><title>Epstein–Barr-Virus Induced Lymphoproliferation: Implications for Antiviral Chemotherapy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative syndrome,
1
,
2
recipients of renal,
3
bone-marrow,
4
or cardiac transplants,
5
and patients with severe combined immunodeficiency,
6
ataxia telangiectasia,
7
or the acquired immunodeficiency syndrome
8
have had fatal EBV-induced lymphoproliferative disorders. Infrequently, normal persons may die of EBV-induced lymphoproliferative disorders
9
including those of the central nervous system.
10
Treatment of these disorders has not been particularly successful, and antiviral agents are being investigated.
One such agent, acyclovir (9-[2-hydroxyethoxy-methyl] guanine) was recently found to be . . .</description><subject>Acyclovir - therapeutic use</subject><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antibodies, Viral - analysis</subject><subject>Antigens</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Case reports</subject><subject>Child</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - analysis</subject><subject>Electrophoresis, Agar Gel</subject><subject>Epstein-Barr virus</subject><subject>Female</subject><subject>Genes, Viral</subject><subject>Genomes</subject><subject>Herpesviridae Infections - drug therapy</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Liver</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphoproliferative Disorders - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nucleic Acid Hybridization</subject><subject>Pediatrics</subject><subject>Pharmacology. Drug treatments</subject><subject>Spleen</subject><subject>Transplants & implants</subject><subject>Virus Replication - drug effects</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kLtOAzEQRS0ECiHwBQgJCUSDFuz1Y-0SogBBARqgtbx-iI32EezdIh3_wB_yJThklQIhZoop5sy9owvAIYIXCFJ2-Ti5f0CCE4QgwgghDtkWGCKKcUIIZNtgCGHKE5IJvAv2QpjDWIiIARgwKGKzIYCTRWhtUX99fF4r75PXwnfheFqbTltzPFtWi7dm4ZuycNartmjqfbDjVBnsQT9H4OVm8jy-S2ZPt9Px1SzRmOA24ZxylGPokDaK5Zpio7RJc0cJUzp1jgiOLWGG44xibohIUyUcxJpziyHEI3C21o3u750NrayKoG1Zqto2XZAcpRlhRETw5Bc4bzpfx98k4lkUT6lYyeE1pX0TgrdOLnxRKb-UCMpVmvKPNOPVUa_d5ZU1m5s-vrg_7fcqaFU6r2pdhA3GuaDZj_n5GquqIGs7r_41_QZejod8</recordid><startdate>19841101</startdate><enddate>19841101</enddate><creator>Sullivan, John L</creator><creator>Medveczky, Peter</creator><creator>Forman, Stephen J</creator><creator>Baker, Sharon M</creator><creator>Monroe, James E</creator><creator>Mulder, Carel</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19841101</creationdate><title>Epstein–Barr-Virus Induced Lymphoproliferation</title><author>Sullivan, John L ; Medveczky, Peter ; Forman, Stephen J ; Baker, Sharon M ; Monroe, James E ; Mulder, Carel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-88581b30f1cda6bc53dacd2bf546ac2ff4983e46d837538d4922a9f03c88e3003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acyclovir - therapeutic use</topic><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antibodies, Viral - analysis</topic><topic>Antigens</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Case reports</topic><topic>Child</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Viral - analysis</topic><topic>Electrophoresis, Agar Gel</topic><topic>Epstein-Barr virus</topic><topic>Female</topic><topic>Genes, Viral</topic><topic>Genomes</topic><topic>Herpesviridae Infections - drug therapy</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Liver</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphoproliferative Disorders - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nucleic Acid Hybridization</topic><topic>Pediatrics</topic><topic>Pharmacology. Drug treatments</topic><topic>Spleen</topic><topic>Transplants & implants</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sullivan, John L</creatorcontrib><creatorcontrib>Medveczky, Peter</creatorcontrib><creatorcontrib>Forman, Stephen J</creatorcontrib><creatorcontrib>Baker, Sharon M</creatorcontrib><creatorcontrib>Monroe, James E</creatorcontrib><creatorcontrib>Mulder, Carel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sullivan, John L</au><au>Medveczky, Peter</au><au>Forman, Stephen J</au><au>Baker, Sharon M</au><au>Monroe, James E</au><au>Mulder, Carel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein–Barr-Virus Induced Lymphoproliferation: Implications for Antiviral Chemotherapy</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1984-11-01</date><risdate>1984</risdate><volume>311</volume><issue>18</issue><spage>1163</spage><epage>1167</epage><pages>1163-1167</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative syndrome,
1
,
2
recipients of renal,
3
bone-marrow,
4
or cardiac transplants,
5
and patients with severe combined immunodeficiency,
6
ataxia telangiectasia,
7
or the acquired immunodeficiency syndrome
8
have had fatal EBV-induced lymphoproliferative disorders. Infrequently, normal persons may die of EBV-induced lymphoproliferative disorders
9
including those of the central nervous system.
10
Treatment of these disorders has not been particularly successful, and antiviral agents are being investigated.
One such agent, acyclovir (9-[2-hydroxyethoxy-methyl] guanine) was recently found to be . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>6090906</pmid><doi>10.1056/NEJM198411013111806</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1984-11, Vol.311 (18), p.1163-1167 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81274649 |
| source | MEDLINE; ProQuest Central UK/Ireland |
| subjects | Acyclovir - therapeutic use Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Viral - analysis Antigens Antiviral agents Biological and medical sciences Case reports Child Deoxyribonucleic acid DNA DNA, Viral - analysis Electrophoresis, Agar Gel Epstein-Barr virus Female Genes, Viral Genomes Herpesviridae Infections - drug therapy Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Humans Immunoglobulins Infections Liver Lymphatic system Lymphocytes Lymphoproliferative Disorders - drug therapy Male Medical sciences Nucleic Acid Hybridization Pediatrics Pharmacology. Drug treatments Spleen Transplants & implants Virus Replication - drug effects |
| title | Epstein–Barr-Virus Induced Lymphoproliferation: Implications for Antiviral Chemotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T08%3A56%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epstein%E2%80%93Barr-Virus%20Induced%20Lymphoproliferation:%20Implications%20for%20Antiviral%20Chemotherapy&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Sullivan,%20John%20L&rft.date=1984-11-01&rft.volume=311&rft.issue=18&rft.spage=1163&rft.epage=1167&rft.pages=1163-1167&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJM198411013111806&rft_dat=%3Cproquest_cross%3E81274649%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1877532590&rft_id=info:pmid/6090906&rfr_iscdi=true |