Effects of renal factors on in vitro hepatic cholesterol synthesis in the rat
Two products derived from rat renal tissue have been shown to affect in vitro hepatic cholesterol synthesis. A premevalonate inhibitor of hepatic cholesterol synthesis is associated with the membranes of the renal endoplasmic reticulum. It is stable at −75 C and at 4 C but is heat labile. A pre‐meva...
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| Veröffentlicht in: | Lipids 1971-10, Vol.6 (10), p.751-757 |
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| container_title | Lipids |
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| creator | Haven, Guy T. Jacobi, Herbert P. |
| description | Two products derived from rat renal tissue have been shown to affect in vitro hepatic cholesterol synthesis. A premevalonate inhibitor of hepatic cholesterol synthesis is associated with the membranes of the renal endoplasmic reticulum. It is stable at −75 C and at 4 C but is heat labile. A pre‐mevalonate stimulator of in vitro hepatic cholesterol synthesis is located within renal lysosomes and can be prepared in a nonsedimentable form by extraction with hypotonic buffer. While it is stable at −75 C, it loses activity at 4 C. Both of these products appear to have a molecular weight in excess of 150,000 as determined by gel filtration. |
| doi_str_mv | 10.1007/BF02531302 |
| format | Article |
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A premevalonate inhibitor of hepatic cholesterol synthesis is associated with the membranes of the renal endoplasmic reticulum. It is stable at −75 C and at 4 C but is heat labile. A pre‐mevalonate stimulator of in vitro hepatic cholesterol synthesis is located within renal lysosomes and can be prepared in a nonsedimentable form by extraction with hypotonic buffer. While it is stable at −75 C, it loses activity at 4 C. Both of these products appear to have a molecular weight in excess of 150,000 as determined by gel filtration.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/BF02531302</identifier><identifier>PMID: 5141498</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Acetates - metabolism ; Animals ; Blood Proteins - pharmacology ; Carbon Isotopes ; Cattle ; Cholesterol - biosynthesis ; Chromatography, Gel ; Cold Temperature ; Cytoplasm ; Endoplasmic Reticulum ; Hot Temperature ; In Vitro Techniques ; Kidney ; Liver - metabolism ; Lysosomes ; Male ; Mevalonic Acid - metabolism ; Microsomes ; Microsomes, Liver - metabolism ; Molecular Weight ; Phospholipids - pharmacology ; Rats ; Sodium - metabolism ; Subcellular Fractions</subject><ispartof>Lipids, 1971-10, Vol.6 (10), p.751-757</ispartof><rights>1971 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3231-19e04d187aae880f890126e4d269071cd0b478b659fa5dffe47272b8fd3f3b383</citedby><cites>FETCH-LOGICAL-c3231-19e04d187aae880f890126e4d269071cd0b478b659fa5dffe47272b8fd3f3b383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5141498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haven, Guy T.</creatorcontrib><creatorcontrib>Jacobi, Herbert P.</creatorcontrib><title>Effects of renal factors on in vitro hepatic cholesterol synthesis in the rat</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Two products derived from rat renal tissue have been shown to affect in vitro hepatic cholesterol synthesis. A premevalonate inhibitor of hepatic cholesterol synthesis is associated with the membranes of the renal endoplasmic reticulum. It is stable at −75 C and at 4 C but is heat labile. A pre‐mevalonate stimulator of in vitro hepatic cholesterol synthesis is located within renal lysosomes and can be prepared in a nonsedimentable form by extraction with hypotonic buffer. While it is stable at −75 C, it loses activity at 4 C. Both of these products appear to have a molecular weight in excess of 150,000 as determined by gel filtration.</description><subject>Acetates - metabolism</subject><subject>Animals</subject><subject>Blood Proteins - pharmacology</subject><subject>Carbon Isotopes</subject><subject>Cattle</subject><subject>Cholesterol - biosynthesis</subject><subject>Chromatography, Gel</subject><subject>Cold Temperature</subject><subject>Cytoplasm</subject><subject>Endoplasmic Reticulum</subject><subject>Hot Temperature</subject><subject>In Vitro Techniques</subject><subject>Kidney</subject><subject>Liver - metabolism</subject><subject>Lysosomes</subject><subject>Male</subject><subject>Mevalonic Acid - metabolism</subject><subject>Microsomes</subject><subject>Microsomes, Liver - metabolism</subject><subject>Molecular Weight</subject><subject>Phospholipids - pharmacology</subject><subject>Rats</subject><subject>Sodium - metabolism</subject><subject>Subcellular Fractions</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LAzEQxYMotVYv3oWcPAirk68me9TaaqGiBz0v2WxCV7abmqRK_3sjLXrzNG_m_XgMD6FzAtcEQN7czYAKRhjQAzQkQqiiZCAP0RCA8oJTIMfoJMb3vBJeigEaCMKzUkP0NHXOmhSxdzjYXnfYaZN8yIcetz3-bFPweGnXOrUGm6XvbEw2-A7HbZ-WNrbxB8sKB51O0ZHTXbRn-zlCb7Pp6-SxWDw_zCe3i8IwykhBSgu8IUpqbZUCp0ogdGx5Q8clSGIaqLlU9ViUTosmP8gllbRWrmGO1UyxEbrc5a6D_9jkj6pVG43tOt1bv4mVIlQClDSDVzvQBB9jsK5ah3alw7YiUP10V_11l-GLfeqmXtnmF92XlX3Y-V9tZ7f_JFWL-cs9SEHYN8nTdmU</recordid><startdate>197110</startdate><enddate>197110</enddate><creator>Haven, Guy T.</creator><creator>Jacobi, Herbert P.</creator><general>Springer‐Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197110</creationdate><title>Effects of renal factors on in vitro hepatic cholesterol synthesis in the rat</title><author>Haven, Guy T. ; Jacobi, Herbert P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3231-19e04d187aae880f890126e4d269071cd0b478b659fa5dffe47272b8fd3f3b383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Acetates - metabolism</topic><topic>Animals</topic><topic>Blood Proteins - pharmacology</topic><topic>Carbon Isotopes</topic><topic>Cattle</topic><topic>Cholesterol - biosynthesis</topic><topic>Chromatography, Gel</topic><topic>Cold Temperature</topic><topic>Cytoplasm</topic><topic>Endoplasmic Reticulum</topic><topic>Hot Temperature</topic><topic>In Vitro Techniques</topic><topic>Kidney</topic><topic>Liver - metabolism</topic><topic>Lysosomes</topic><topic>Male</topic><topic>Mevalonic Acid - metabolism</topic><topic>Microsomes</topic><topic>Microsomes, Liver - metabolism</topic><topic>Molecular Weight</topic><topic>Phospholipids - pharmacology</topic><topic>Rats</topic><topic>Sodium - metabolism</topic><topic>Subcellular Fractions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haven, Guy T.</creatorcontrib><creatorcontrib>Jacobi, Herbert P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haven, Guy T.</au><au>Jacobi, Herbert P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of renal factors on in vitro hepatic cholesterol synthesis in the rat</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1971-10</date><risdate>1971</risdate><volume>6</volume><issue>10</issue><spage>751</spage><epage>757</epage><pages>751-757</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Two products derived from rat renal tissue have been shown to affect in vitro hepatic cholesterol synthesis. A premevalonate inhibitor of hepatic cholesterol synthesis is associated with the membranes of the renal endoplasmic reticulum. It is stable at −75 C and at 4 C but is heat labile. A pre‐mevalonate stimulator of in vitro hepatic cholesterol synthesis is located within renal lysosomes and can be prepared in a nonsedimentable form by extraction with hypotonic buffer. While it is stable at −75 C, it loses activity at 4 C. Both of these products appear to have a molecular weight in excess of 150,000 as determined by gel filtration.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>5141498</pmid><doi>10.1007/BF02531302</doi><tpages>7</tpages></addata></record> |
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| ispartof | Lipids, 1971-10, Vol.6 (10), p.751-757 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acetates - metabolism Animals Blood Proteins - pharmacology Carbon Isotopes Cattle Cholesterol - biosynthesis Chromatography, Gel Cold Temperature Cytoplasm Endoplasmic Reticulum Hot Temperature In Vitro Techniques Kidney Liver - metabolism Lysosomes Male Mevalonic Acid - metabolism Microsomes Microsomes, Liver - metabolism Molecular Weight Phospholipids - pharmacology Rats Sodium - metabolism Subcellular Fractions |
| title | Effects of renal factors on in vitro hepatic cholesterol synthesis in the rat |
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