Patterns of Polymorphism and Linkage Disequilibrium Suggest Independent Origins of the Human Growth Hormone Gene Cluster

Six restriction fragment length polymorphisms (RFLPs) detected in the human growth hormone-human chorionic somatomammotropin (hGH-hCS) gene cluster were studied in Mediterraneans, Northern Europeans, and American Blacks; the polymorphisms showed that, on the average, one of 500 bases in this cluster...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1984-10, Vol.81 (19), p.6085-6089
Hauptverfasser:	Chakravarti, Aravinda, Phillips, John A., Mellits, Kenneth H., Buetow, Kenneth H., Seeburg, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group Amniotic Fluid - metabolism Base Sequence Chromosomes DNA DNA Restriction Enzymes European Continental Ancestry Group Female Genes Genetic Linkage Genetic loci Growth Hormone - genetics Haplotypes Human genetics Humans Leukocytes - metabolism Linkage disequilibrium Multigene family Nucleotides Placental Lactogen - genetics Plasmids Polymorphism, Genetic Pregnancy Restriction fragment length polymorphism
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