Mechanism of circulatory effects of chlorcyclizine
Intravenous administration of chlorcyclizine produced a biphasic response characterized by an initial and abrupt depressor response followed by a gradual and sustained pressor response. Analysis of this response showed that the initial depressor response was of peripheral origin and was not mediated...
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| Veröffentlicht in: | European journal of pharmacology 1971-01, Vol.15 (3), p.386-388 |
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| container_end_page | 388 |
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| container_issue | 3 |
| container_start_page | 386 |
| container_title | European journal of pharmacology |
| container_volume | 15 |
| creator | Sinha, J.N. Shamsi, M.A. Gupta, M.L. Kohli, R.P. Bhargava, K.P. |
| description | Intravenous administration of chlorcyclizine produced a biphasic response characterized by an initial and abrupt depressor response followed by a gradual and sustained pressor response. Analysis of this response showed that the initial depressor response was of peripheral origin and was not mediated by cholinergic, histaminergic or serotonergic mechanisms, whereas the delayed pressor response apparently resulted from activation of supramedullary sympathetic neurones leading to a massive release of catecholamines from the sympatho-adrenal system. |
| doi_str_mv | 10.1016/0014-2999(71)90110-5 |
| format | Article |
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| ispartof | European journal of pharmacology, 1971-01, Vol.15 (3), p.386-388 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenal Medulla - physiology Animals Biphasic response Blood Circulation - drug effects Blood Pressure - drug effects Cats Chlorcyclizine Female Histamine H1 Antagonists - pharmacology Male Piperazines - pharmacology Sympatho adrenal system |
| title | Mechanism of circulatory effects of chlorcyclizine |
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