Effects of Sexual Hormones on the Adrenergic Innervation and the Monoamine Oxidase Activity in the Rat Ventral Prostate
Intact and castrated rats were injected intramuscularly with polyoestradiol phosphate, (PEP), (estradurin®), 8 mg/kg, or with vehicle. Other rats were castrated and injected intramuscularly with testosterone‐hexyloxyphenyl‐propionate (A), (andradurin®), 60 mg/kg, alone or in combination with PEP. Af...
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| Veröffentlicht in: | Acta pharmacologica et toxicologica 1971-01, Vol.30 (3‐4), p.208-214 |
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| container_title | Acta pharmacologica et toxicologica |
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| creator | Müntzing, Jonas |
| description | Intact and castrated rats were injected intramuscularly with polyoestradiol phosphate, (PEP), (estradurin®), 8 mg/kg, or with vehicle. Other rats were castrated and injected intramuscularly with testosterone‐hexyloxyphenyl‐propionate (A), (andradurin®), 60 mg/kg, alone or in combination with PEP. After 20 days the adrenergic innervation of the ventral prostate was studied histochemically. It was found that the normally sparse innervation, restricted to the stroma, was markedly increased by those treatments which reduced the androgenic influence on the prostate. This increased innervation was accompanied by an increase of histochemically and biochemically demonstrable monoamine oxidase (MAO). |
| doi_str_mv | 10.1111/j.1600-0773.1971.tb00652.x |
| format | Article |
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This increased innervation was accompanied by an increase of histochemically and biochemically demonstrable monoamine oxidase (MAO).</description><subject>Animals</subject><subject>Castration</subject><subject>Estradiol - pharmacology</subject><subject>Male</subject><subject>monoamine oxidase</subject><subject>Monoamine Oxidase - analysis</subject><subject>Oestrogens</subject><subject>prostate</subject><subject>Prostate - enzymology</subject><subject>Prostate - innervation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>sympathetic nervous system</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Testosterone - pharmacology</subject><subject>Time Factors</subject><issn>0001-6683</issn><issn>1600-0773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFFv2yAUhVG1qovS_oRKaA97swfGGHsvUxa1a6RUrbZur4jAdUtk4w5Ik_z74SXKe3nh3nvuOaAPoU-U5DSdL-ucVoRkRAiW00bQPK4IqXiR787Q5CR9QBNCCM2qqmYf0VUI69QSXrGCNxfoglNBm5JO0PambUHHgIcW_4LdRnX4bvD94CCNHI4vgGfGgwP_bDVeuFS8qWiTpJz5L98PblC9dYAfdtaokAw62jcb99geAn6qiP-Aiz6FP_ohRBXhEp23qgtwdbyn6PftzdP8Lls-_FjMZ8tMM0GKrBTQmJpx3fKqNvXK6LoRIESrWElVQSvKqS4KQgvOFYc0rInRlJhatAUpNZuiz4fcVz_83UCIsrdBQ9cpB8MmyHp0lqxKi18Pizr9MHho5au3vfJ7SYkcwcu1HOnKka4cwcsjeLlL5uvjK5tVD-ZkPWJO-reDvrUd7N-RLL_PH59Sxf4BEOiTBg</recordid><startdate>19710101</startdate><enddate>19710101</enddate><creator>Müntzing, Jonas</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19710101</creationdate><title>Effects of Sexual Hormones on the Adrenergic Innervation and the Monoamine Oxidase Activity in the Rat Ventral Prostate</title><author>Müntzing, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3702-47e9d835cf568d8bdc897e77fa341a216151c2201255a5e34180dc10d87f204c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Castration</topic><topic>Estradiol - pharmacology</topic><topic>Male</topic><topic>monoamine oxidase</topic><topic>Monoamine Oxidase - analysis</topic><topic>Oestrogens</topic><topic>prostate</topic><topic>Prostate - enzymology</topic><topic>Prostate - innervation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>sympathetic nervous system</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Testosterone - pharmacology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Müntzing, Jonas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta pharmacologica et toxicologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müntzing, Jonas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Sexual Hormones on the Adrenergic Innervation and the Monoamine Oxidase Activity in the Rat Ventral Prostate</atitle><jtitle>Acta pharmacologica et toxicologica</jtitle><addtitle>Acta Pharmacol Toxicol (Copenh)</addtitle><date>1971-01-01</date><risdate>1971</risdate><volume>30</volume><issue>3‐4</issue><spage>208</spage><epage>214</epage><pages>208-214</pages><issn>0001-6683</issn><eissn>1600-0773</eissn><abstract>Intact and castrated rats were injected intramuscularly with polyoestradiol phosphate, (PEP), (estradurin®), 8 mg/kg, or with vehicle. Other rats were castrated and injected intramuscularly with testosterone‐hexyloxyphenyl‐propionate (A), (andradurin®), 60 mg/kg, alone or in combination with PEP. After 20 days the adrenergic innervation of the ventral prostate was studied histochemically. It was found that the normally sparse innervation, restricted to the stroma, was markedly increased by those treatments which reduced the androgenic influence on the prostate. This increased innervation was accompanied by an increase of histochemically and biochemically demonstrable monoamine oxidase (MAO).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>5171941</pmid><doi>10.1111/j.1600-0773.1971.tb00652.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6683 |
| ispartof | Acta pharmacologica et toxicologica, 1971-01, Vol.30 (3‐4), p.208-214 |
| issn | 0001-6683 1600-0773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Castration Estradiol - pharmacology Male monoamine oxidase Monoamine Oxidase - analysis Oestrogens prostate Prostate - enzymology Prostate - innervation Rats Rats, Inbred Strains sympathetic nervous system Sympathetic Nervous System - drug effects Testosterone - pharmacology Time Factors |
| title | Effects of Sexual Hormones on the Adrenergic Innervation and the Monoamine Oxidase Activity in the Rat Ventral Prostate |
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