Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic
Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfac...
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| Veröffentlicht in: | Neuroscience letters 1984-08, Vol.48 (3), p.247-254 |
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| container_title | Neuroscience letters |
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| creator | Butler, Ann B. Graziadei, P.P.C. Graziadei, G.A.Monti Slotnick, Burton M. |
| description | Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfactory nucleus, and formed glomerular-like structures. On the adult operated side there was extensive scar formation which prevented in-growing sensory axons from contacting the brain. All experimental animals acquired the tone-light discrimination but failed to show any evidence of odor detection. These results indicate that reconstituted olfactory projections which terminate in the frontal neocortex or anterior olfactory nucleus do not support olfaction. |
| doi_str_mv | 10.1016/0304-3940(84)90046-6 |
| format | Article |
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These results indicate that reconstituted olfactory projections which terminate in the frontal neocortex or anterior olfactory nucleus do not support olfaction.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(84)90046-6</identifier><identifier>PMID: 6483285</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acoustic Stimulation ; Animals ; anosmia ; Biological and medical sciences ; Central Nervous System - physiology ; Cerebral Cortex - physiology ; Discrimination (Psychology) ; Fundamental and applied biological sciences. Psychology ; Male ; Nerve Regeneration ; neural plasticity ; Neuronal Plasticity ; Neurons - physiology ; Odorants ; olfaction ; olfactory bulb ; Olfactory Bulb - physiology ; olfactory discrimination ; Olfactory Pathways - physiology ; Olfactory system and olfaction. Gustatory system and gustation ; Photic Stimulation ; Physical Stimulation ; Rats ; Rats, Inbred Strains ; Smell ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1984-08, Vol.48 (3), p.247-254</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-448ae7a4f2cb0ade1d830eddeb9b104c8dc53ee749bbe62fb902fed9d0766af23</citedby><cites>FETCH-LOGICAL-c417t-448ae7a4f2cb0ade1d830eddeb9b104c8dc53ee749bbe62fb902fed9d0766af23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394084900466$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9683846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6483285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butler, Ann B.</creatorcontrib><creatorcontrib>Graziadei, P.P.C.</creatorcontrib><creatorcontrib>Graziadei, G.A.Monti</creatorcontrib><creatorcontrib>Slotnick, Burton M.</creatorcontrib><title>Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfactory nucleus, and formed glomerular-like structures. On the adult operated side there was extensive scar formation which prevented in-growing sensory axons from contacting the brain. All experimental animals acquired the tone-light discrimination but failed to show any evidence of odor detection. These results indicate that reconstituted olfactory projections which terminate in the frontal neocortex or anterior olfactory nucleus do not support olfaction.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>anosmia</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System - physiology</subject><subject>Cerebral Cortex - physiology</subject><subject>Discrimination (Psychology)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Nerve Regeneration</subject><subject>neural plasticity</subject><subject>Neuronal Plasticity</subject><subject>Neurons - physiology</subject><subject>Odorants</subject><subject>olfaction</subject><subject>olfactory bulb</subject><subject>Olfactory Bulb - physiology</subject><subject>olfactory discrimination</subject><subject>Olfactory Pathways - physiology</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Photic Stimulation</subject><subject>Physical Stimulation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Smell</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAURS1E1Q6Ff0ClLBCii8Bz7Dj2BglV0FaqYFPWlj9ehFFit3am1fTX42FGs2xXb3HPvXo6hLyn8JkCFV-AAW-Z4vBJ8nMFwEUrXpEVlUPXDmroXpPVATkhb0r5CwA97fkxORZcsk72K3L7E1M0i5mmTWPXk0W3pDk8oW-yWUrzGJY_TcTHJk2jqVHetBGTS3kJzkyNSzHWRkixNCZjY2Iqc3BvydFopoLv9veU_P7x_fbiqr35dXl98e2mdZwOS8u5NDgYPnbOgvFIvWSA3qNVlgJ30rueIQ5cWYuiG62CbkSvPAxCmLFjp-Tjbvcup_s1lkXPoTicJlOfXBctadf3FNSLIGWK8Z4OFeQ70OVUSsZR3-Uwm7zRFPTWut4q1VulWnL937oWtXa231_bGf2htNdc8w_73JTqbcwmulAOmBKSSb6d-brDsEp7CJh1cQGjQx9y1ax9Cs__8Q9Gz6AI</recordid><startdate>19840810</startdate><enddate>19840810</enddate><creator>Butler, Ann B.</creator><creator>Graziadei, P.P.C.</creator><creator>Graziadei, G.A.Monti</creator><creator>Slotnick, Burton M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840810</creationdate><title>Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic</title><author>Butler, Ann B. ; Graziadei, P.P.C. ; Graziadei, G.A.Monti ; Slotnick, Burton M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-448ae7a4f2cb0ade1d830eddeb9b104c8dc53ee749bbe62fb902fed9d0766af23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>anosmia</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System - physiology</topic><topic>Cerebral Cortex - physiology</topic><topic>Discrimination (Psychology)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Nerve Regeneration</topic><topic>neural plasticity</topic><topic>Neuronal Plasticity</topic><topic>Neurons - physiology</topic><topic>Odorants</topic><topic>olfaction</topic><topic>olfactory bulb</topic><topic>Olfactory Bulb - physiology</topic><topic>olfactory discrimination</topic><topic>Olfactory Pathways - physiology</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Photic Stimulation</topic><topic>Physical Stimulation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Smell</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butler, Ann B.</creatorcontrib><creatorcontrib>Graziadei, P.P.C.</creatorcontrib><creatorcontrib>Graziadei, G.A.Monti</creatorcontrib><creatorcontrib>Slotnick, Burton M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butler, Ann B.</au><au>Graziadei, P.P.C.</au><au>Graziadei, G.A.Monti</au><au>Slotnick, Burton M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1984-08-10</date><risdate>1984</risdate><volume>48</volume><issue>3</issue><spage>247</spage><epage>254</epage><pages>247-254</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfactory nucleus, and formed glomerular-like structures. On the adult operated side there was extensive scar formation which prevented in-growing sensory axons from contacting the brain. All experimental animals acquired the tone-light discrimination but failed to show any evidence of odor detection. These results indicate that reconstituted olfactory projections which terminate in the frontal neocortex or anterior olfactory nucleus do not support olfaction.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6483285</pmid><doi>10.1016/0304-3940(84)90046-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1984-08, Vol.48 (3), p.247-254 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81255109 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acoustic Stimulation Animals anosmia Biological and medical sciences Central Nervous System - physiology Cerebral Cortex - physiology Discrimination (Psychology) Fundamental and applied biological sciences. Psychology Male Nerve Regeneration neural plasticity Neuronal Plasticity Neurons - physiology Odorants olfaction olfactory bulb Olfactory Bulb - physiology olfactory discrimination Olfactory Pathways - physiology Olfactory system and olfaction. Gustatory system and gustation Photic Stimulation Physical Stimulation Rats Rats, Inbred Strains Smell Vertebrates: nervous system and sense organs |
| title | Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic |
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