Immune complexes and antinuclear, antinucleolar, and anticentromere antibodies in scleroderma
Forty-one patients with various forms of systemic sclerosis (scleroderma) and positive antinuclear antibodies of nucleolar (ten patients), speckled (eleven patients), or centromere pattern (twenty patients) were selected for study of immune complexes by the radioisotope labeled Clq binding and the r...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1984-09, Vol.11 (3), p.461-467 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Chen, Ze-yi Virella, Gabriel Tung, Hsiaoho Edward Ainsworth, Sterling K. Silver, Richard M. Wang, An-Chuan LaVia, Mariano F. Maricq, Hildegard R. Dobson, Richard L. |
| description | Forty-one patients with various forms of systemic sclerosis (scleroderma) and positive antinuclear antibodies of nucleolar (ten patients), speckled (eleven patients), or centromere pattern (twenty patients) were selected for study of immune complexes by the radioisotope labeled Clq binding and the radioisotope labeled protein A binding methods. The presence of immune complexes was found by the Clq binding assay in sixteen patients (39%) and by a protein A binding assay in eight patients (20%). Overall, 46% of patients (19/41) had immune complexes. A lower incidence of organ involvement and fewer positive results in the screening of serum immune complexes were observed in patients with centromere antibody (35%) than in patients with nucleolar (60%) or speckled pattern (55%). Patients with immune complexes had higher frequencies of kidney, heart, and muscle involvement and digital ulceration than did patients with no detectable immune complexes, but the differences were not statistically significant. Diffuse skin involvement was not related to the presence of immune complexes. |
| doi_str_mv | 10.1016/S0190-9622(84)70191-5 |
| format | Article |
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The presence of immune complexes was found by the Clq binding assay in sixteen patients (39%) and by a protein A binding assay in eight patients (20%). Overall, 46% of patients (19/41) had immune complexes. A lower incidence of organ involvement and fewer positive results in the screening of serum immune complexes were observed in patients with centromere antibody (35%) than in patients with nucleolar (60%) or speckled pattern (55%). Patients with immune complexes had higher frequencies of kidney, heart, and muscle involvement and digital ulceration than did patients with no detectable immune complexes, but the differences were not statistically significant. Diffuse skin involvement was not related to the presence of immune complexes.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(84)70191-5</identifier><identifier>PMID: 6237134</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Antibodies, Antinuclear - isolation & purification ; Antigen-Antibody Complex - isolation & purification ; Autoimmune Diseases - diagnosis ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Cell Nucleolus - immunology ; Centromere - immunology ; Chromosomes - immunology ; Diagnosis, Differential ; Humans ; Immune Complex Diseases - diagnosis ; Immune Complex Diseases - immunology ; Immunologic Techniques ; Medical sciences ; Middle Aged ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Scleroderma, Systemic - diagnosis ; Scleroderma, Systemic - immunology ; Scleroderma, Systemic - pathology ; Skin - ultrastructure</subject><ispartof>Journal of the American Academy of Dermatology, 1984-09, Vol.11 (3), p.461-467</ispartof><rights>1984 American Academy of Dermatology, Inc.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-1e51d0c8c364d04f3969e40b7a1438a1257dff27b1023750af0a0f0a400931983</citedby><cites>FETCH-LOGICAL-c389t-1e51d0c8c364d04f3969e40b7a1438a1257dff27b1023750af0a0f0a400931983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0190962284701915$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8918152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6237134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ze-yi</creatorcontrib><creatorcontrib>Virella, Gabriel</creatorcontrib><creatorcontrib>Tung, Hsiaoho Edward</creatorcontrib><creatorcontrib>Ainsworth, Sterling K.</creatorcontrib><creatorcontrib>Silver, Richard M.</creatorcontrib><creatorcontrib>Wang, An-Chuan</creatorcontrib><creatorcontrib>LaVia, Mariano F.</creatorcontrib><creatorcontrib>Maricq, Hildegard R.</creatorcontrib><creatorcontrib>Dobson, Richard L.</creatorcontrib><title>Immune complexes and antinuclear, antinucleolar, and anticentromere antibodies in scleroderma</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Forty-one patients with various forms of systemic sclerosis (scleroderma) and positive antinuclear antibodies of nucleolar (ten patients), speckled (eleven patients), or centromere pattern (twenty patients) were selected for study of immune complexes by the radioisotope labeled Clq binding and the radioisotope labeled protein A binding methods. The presence of immune complexes was found by the Clq binding assay in sixteen patients (39%) and by a protein A binding assay in eight patients (20%). Overall, 46% of patients (19/41) had immune complexes. A lower incidence of organ involvement and fewer positive results in the screening of serum immune complexes were observed in patients with centromere antibody (35%) than in patients with nucleolar (60%) or speckled pattern (55%). Patients with immune complexes had higher frequencies of kidney, heart, and muscle involvement and digital ulceration than did patients with no detectable immune complexes, but the differences were not statistically significant. Diffuse skin involvement was not related to the presence of immune complexes.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Antinuclear - isolation & purification</subject><subject>Antigen-Antibody Complex - isolation & purification</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleolus - immunology</subject><subject>Centromere - immunology</subject><subject>Chromosomes - immunology</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Immune Complex Diseases - diagnosis</subject><subject>Immune Complex Diseases - immunology</subject><subject>Immunologic Techniques</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Scleroderma, Systemic - diagnosis</subject><subject>Scleroderma, Systemic - immunology</subject><subject>Scleroderma, Systemic - pathology</subject><subject>Skin - ultrastructure</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotVZ_gtCFiIKjySQzSVYixUeh4EJdSkiTOxCZmdRkRvTfm3ZKXbq4hMP57iMHoVOCrwkm5c0LJhJnsszzC8EueVIkK_bQmGDJs5ILvo_GO-QQHcX4gTGWjPIRGpU55YSyMXqfN03fwtT4ZlXDN8Spbm2qzrW9qUGHqz_h60EOvoG2C76BABu59NalbtdOY0KDtxAafYwOKl1HONm-E_T2cP86e8oWz4_z2d0iM1TILiNQEIuNMLRkFrOKylICw0uuCaNCk7zgtqpyviQ43V1gXWGNU7H0H0qkoBN0PsxdBf_ZQ-xU46KButYt-D4qkUbkQtIEFgNogo8xQKVWwTU6_CiC1TpWtYlVrTNTgqlNrKpIfafbBf2yAbvr2uaY_LOtr6PRdRV0a1zcYUISQYo8YbcDBimMLwdBReOgNWBdANMp690_h_wC0VyULw</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Chen, Ze-yi</creator><creator>Virella, Gabriel</creator><creator>Tung, Hsiaoho Edward</creator><creator>Ainsworth, Sterling K.</creator><creator>Silver, Richard M.</creator><creator>Wang, An-Chuan</creator><creator>LaVia, Mariano F.</creator><creator>Maricq, Hildegard R.</creator><creator>Dobson, Richard L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198409</creationdate><title>Immune complexes and antinuclear, antinucleolar, and anticentromere antibodies in scleroderma</title><author>Chen, Ze-yi ; Virella, Gabriel ; Tung, Hsiaoho Edward ; Ainsworth, Sterling K. ; Silver, Richard M. ; Wang, An-Chuan ; LaVia, Mariano F. ; Maricq, Hildegard R. ; Dobson, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-1e51d0c8c364d04f3969e40b7a1438a1257dff27b1023750af0a0f0a400931983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Antinuclear - isolation & purification</topic><topic>Antigen-Antibody Complex - isolation & purification</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Nucleolus - immunology</topic><topic>Centromere - immunology</topic><topic>Chromosomes - immunology</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Immune Complex Diseases - diagnosis</topic><topic>Immune Complex Diseases - immunology</topic><topic>Immunologic Techniques</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Scleroderma, Systemic - diagnosis</topic><topic>Scleroderma, Systemic - immunology</topic><topic>Scleroderma, Systemic - pathology</topic><topic>Skin - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ze-yi</creatorcontrib><creatorcontrib>Virella, Gabriel</creatorcontrib><creatorcontrib>Tung, Hsiaoho Edward</creatorcontrib><creatorcontrib>Ainsworth, Sterling K.</creatorcontrib><creatorcontrib>Silver, Richard M.</creatorcontrib><creatorcontrib>Wang, An-Chuan</creatorcontrib><creatorcontrib>LaVia, Mariano F.</creatorcontrib><creatorcontrib>Maricq, Hildegard R.</creatorcontrib><creatorcontrib>Dobson, Richard L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ze-yi</au><au>Virella, Gabriel</au><au>Tung, Hsiaoho Edward</au><au>Ainsworth, Sterling K.</au><au>Silver, Richard M.</au><au>Wang, An-Chuan</au><au>LaVia, Mariano F.</au><au>Maricq, Hildegard R.</au><au>Dobson, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune complexes and antinuclear, antinucleolar, and anticentromere antibodies in scleroderma</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1984-09</date><risdate>1984</risdate><volume>11</volume><issue>3</issue><spage>461</spage><epage>467</epage><pages>461-467</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Forty-one patients with various forms of systemic sclerosis (scleroderma) and positive antinuclear antibodies of nucleolar (ten patients), speckled (eleven patients), or centromere pattern (twenty patients) were selected for study of immune complexes by the radioisotope labeled Clq binding and the radioisotope labeled protein A binding methods. The presence of immune complexes was found by the Clq binding assay in sixteen patients (39%) and by a protein A binding assay in eight patients (20%). Overall, 46% of patients (19/41) had immune complexes. A lower incidence of organ involvement and fewer positive results in the screening of serum immune complexes were observed in patients with centromere antibody (35%) than in patients with nucleolar (60%) or speckled pattern (55%). Patients with immune complexes had higher frequencies of kidney, heart, and muscle involvement and digital ulceration than did patients with no detectable immune complexes, but the differences were not statistically significant. Diffuse skin involvement was not related to the presence of immune complexes.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>6237134</pmid><doi>10.1016/S0190-9622(84)70191-5</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1984-09, Vol.11 (3), p.461-467 |
| issn | 0190-9622 1097-6787 |
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| subjects | Adult Aged Antibodies, Antinuclear - isolation & purification Antigen-Antibody Complex - isolation & purification Autoimmune Diseases - diagnosis Autoimmune Diseases - immunology Biological and medical sciences Cell Nucleolus - immunology Centromere - immunology Chromosomes - immunology Diagnosis, Differential Humans Immune Complex Diseases - diagnosis Immune Complex Diseases - immunology Immunologic Techniques Medical sciences Middle Aged Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - diagnosis Scleroderma, Systemic - immunology Scleroderma, Systemic - pathology Skin - ultrastructure |
| title | Immune complexes and antinuclear, antinucleolar, and anticentromere antibodies in scleroderma |
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