Primary and secondary structure of 7-3 (K) RNA of Novikoff hepatoma
7-3 RNA (also known as K-RNA and 7SK-RNA) is a distinct small RNA found in insect to mammalian cells. Previous studies showed that this RNA is not capped, contains no modified nucleotides, is conserved through evolution, is synthesized by RNA polymerase III, and, in part, is associated by polyriboso...
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| Veröffentlicht in: | The Journal of biological chemistry 1984-10, Vol.259 (19), p.12265-12270 |
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| container_title | The Journal of biological chemistry |
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| creator | REDDY, R HENNING, D SUBRAHMANYAM, C. S BUSCH, H |
| description | 7-3 RNA (also known as K-RNA and 7SK-RNA) is a distinct small RNA found in insect to mammalian cells. Previous studies showed
that this RNA is not capped, contains no modified nucleotides, is conserved through evolution, is synthesized by RNA polymerase
III, and, in part, is associated by polyribosomes. In this study, the complete nucleotide sequence of 7-3 RNA was determined
by RNA-sequencing methods, and the sequence is compared with several small RNAs and repetitive DNA sequences for homology.
This 330-nucleotide-long RNA contained pppGp as its 5' terminus and exhibited heterogeneity with respect to the 3'-terminal
AoH. The nucleotide sequence is: (sequence in text) The RNA is G-C rich, and evidence is presented that 7-3 RNA is in a ribonucleoprotein
particle in the cytoplasm. |
| doi_str_mv | 10.1016/S0021-9258(20)71349-9 |
| format | Article |
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that this RNA is not capped, contains no modified nucleotides, is conserved through evolution, is synthesized by RNA polymerase
III, and, in part, is associated by polyribosomes. In this study, the complete nucleotide sequence of 7-3 RNA was determined
by RNA-sequencing methods, and the sequence is compared with several small RNAs and repetitive DNA sequences for homology.
This 330-nucleotide-long RNA contained pppGp as its 5' terminus and exhibited heterogeneity with respect to the 3'-terminal
AoH. The nucleotide sequence is: (sequence in text) The RNA is G-C rich, and evidence is presented that 7-3 RNA is in a ribonucleoprotein
particle in the cytoplasm.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(20)71349-9</identifier><identifier>PMID: 6434539</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Base Sequence ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Liver Neoplasms, Experimental - genetics ; Nucleic Acid Conformation ; Nucleic acids ; Rats ; Ribonuclease T1 - metabolism ; Ribonuclease, Pancreatic - metabolism ; RNA, Neoplasm - analysis ; Rna, ribonucleoproteins</subject><ispartof>The Journal of biological chemistry, 1984-10, Vol.259 (19), p.12265-12270</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-686bb16d0df330933cbbeff41ec61159a4c91d4dc7dc38946f3cac849db2e8c53</citedby><cites>FETCH-LOGICAL-c461t-686bb16d0df330933cbbeff41ec61159a4c91d4dc7dc38946f3cac849db2e8c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9124173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6434539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>REDDY, R</creatorcontrib><creatorcontrib>HENNING, D</creatorcontrib><creatorcontrib>SUBRAHMANYAM, C. S</creatorcontrib><creatorcontrib>BUSCH, H</creatorcontrib><title>Primary and secondary structure of 7-3 (K) RNA of Novikoff hepatoma</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>7-3 RNA (also known as K-RNA and 7SK-RNA) is a distinct small RNA found in insect to mammalian cells. Previous studies showed
that this RNA is not capped, contains no modified nucleotides, is conserved through evolution, is synthesized by RNA polymerase
III, and, in part, is associated by polyribosomes. In this study, the complete nucleotide sequence of 7-3 RNA was determined
by RNA-sequencing methods, and the sequence is compared with several small RNAs and repetitive DNA sequences for homology.
This 330-nucleotide-long RNA contained pppGp as its 5' terminus and exhibited heterogeneity with respect to the 3'-terminal
AoH. The nucleotide sequence is: (sequence in text) The RNA is G-C rich, and evidence is presented that 7-3 RNA is in a ribonucleoprotein
particle in the cytoplasm.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Liver Neoplasms, Experimental - genetics</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleic acids</subject><subject>Rats</subject><subject>Ribonuclease T1 - metabolism</subject><subject>Ribonuclease, Pancreatic - metabolism</subject><subject>RNA, Neoplasm - analysis</subject><subject>Rna, ribonucleoproteins</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtKAzEQhoMoWquPUNgLkXqxmsmpm0spnlCqeADvQjYHu9ptarKr-PZubakhEH7mmxnyITQAfAoYxNkTxgRySXgxJPhkBJTJXG6hHuCC5pTD6zbqbZA9tJ_SO-4Ok7CLdgWjjFPZQ-OHWNU6_mR6brPkTJjbZUpNbE3TRpcFn41ymg1vT7LHyfkyTsJX9RG8z6ZuoZtQ6wO04_UsucP120cvlxfP4-v87v7qZnx-lxsmoMlFIcoShMXWU4olpaYsnfcMnBEAXGpmJFhmzcgaWkgmPDXaFEzakrjCcNpHx6u5ixg-W5caVVfJuNlMz11okyqAcMII7kC-Ak0MKUXn1WL1SwVYLeWpP3lqaUYRrP7kKdn1DdYL2rJ2dtO1ttXVj9Z1nYye-ajnpkobTAJhMKL_2LR6m35X0amyCmbqakW4VNBdQgSnv18IgUo</recordid><startdate>19841010</startdate><enddate>19841010</enddate><creator>REDDY, R</creator><creator>HENNING, D</creator><creator>SUBRAHMANYAM, C. S</creator><creator>BUSCH, H</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19841010</creationdate><title>Primary and secondary structure of 7-3 (K) RNA of Novikoff hepatoma</title><author>REDDY, R ; HENNING, D ; SUBRAHMANYAM, C. S ; BUSCH, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-686bb16d0df330933cbbeff41ec61159a4c91d4dc7dc38946f3cac849db2e8c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Liver Neoplasms, Experimental - genetics</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleic acids</topic><topic>Rats</topic><topic>Ribonuclease T1 - metabolism</topic><topic>Ribonuclease, Pancreatic - metabolism</topic><topic>RNA, Neoplasm - analysis</topic><topic>Rna, ribonucleoproteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REDDY, R</creatorcontrib><creatorcontrib>HENNING, D</creatorcontrib><creatorcontrib>SUBRAHMANYAM, C. S</creatorcontrib><creatorcontrib>BUSCH, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REDDY, R</au><au>HENNING, D</au><au>SUBRAHMANYAM, C. S</au><au>BUSCH, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary and secondary structure of 7-3 (K) RNA of Novikoff hepatoma</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1984-10-10</date><risdate>1984</risdate><volume>259</volume><issue>19</issue><spage>12265</spage><epage>12270</epage><pages>12265-12270</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>7-3 RNA (also known as K-RNA and 7SK-RNA) is a distinct small RNA found in insect to mammalian cells. Previous studies showed
that this RNA is not capped, contains no modified nucleotides, is conserved through evolution, is synthesized by RNA polymerase
III, and, in part, is associated by polyribosomes. In this study, the complete nucleotide sequence of 7-3 RNA was determined
by RNA-sequencing methods, and the sequence is compared with several small RNAs and repetitive DNA sequences for homology.
This 330-nucleotide-long RNA contained pppGp as its 5' terminus and exhibited heterogeneity with respect to the 3'-terminal
AoH. The nucleotide sequence is: (sequence in text) The RNA is G-C rich, and evidence is presented that 7-3 RNA is in a ribonucleoprotein
particle in the cytoplasm.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>6434539</pmid><doi>10.1016/S0021-9258(20)71349-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0021-9258 1083-351X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Liver Neoplasms, Experimental - genetics Nucleic Acid Conformation Nucleic acids Rats Ribonuclease T1 - metabolism Ribonuclease, Pancreatic - metabolism RNA, Neoplasm - analysis Rna, ribonucleoproteins |
| title | Primary and secondary structure of 7-3 (K) RNA of Novikoff hepatoma |
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