Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism
Palmitic acid is a major physiological substrate of the myocardium and its role in myocardial metabolism is well understood. 11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart. A rapid and reliable method...
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| Veröffentlicht in: | International journal of nuclear medicine & biology 1984, Vol.11 (2), p.121-128 |
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| container_end_page | 128 |
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| container_issue | 2 |
| container_start_page | 121 |
| container_title | International journal of nuclear medicine & biology |
| container_volume | 11 |
| creator | Zielinski, Florian Robinson, Gerald |
| description | Palmitic acid is a major physiological substrate of the myocardium and its role in myocardial metabolism is well understood.
11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart.
A rapid and reliable method for producing [
11C]palmitic acid from [
11C]carbon dioxide by the Grignard synthesis is described. All interfering long chain nonradioactive impurities are removed by the purification procedure. As a result, this [
11C]palmitic acid may be used as a tracer for pure palmitic acid in the measurement of regional myocardial function. |
| doi_str_mv | 10.1016/0047-0740(84)90047-0 |
| format | Article |
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11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart.
A rapid and reliable method for producing [
11C]palmitic acid from [
11C]carbon dioxide by the Grignard synthesis is described. All interfering long chain nonradioactive impurities are removed by the purification procedure. As a result, this [
11C]palmitic acid may be used as a tracer for pure palmitic acid in the measurement of regional myocardial function.</description><identifier>ISSN: 0047-0740</identifier><identifier>DOI: 10.1016/0047-0740(84)90047-0</identifier><identifier>PMID: 6332793</identifier><language>eng</language><publisher>Tarrytown, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Carbon Radioisotopes ; Contrast media. Radiopharmaceuticals ; Dogs ; Heart - diagnostic imaging ; Indicators and Reagents ; Medical sciences ; Myocardium - metabolism ; Palmitic Acid ; Palmitic Acids - chemical synthesis ; Pharmacology. Drug treatments ; Tomography, Emission-Computed</subject><ispartof>International journal of nuclear medicine & biology, 1984, Vol.11 (2), p.121-128</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2333-8ea4c63bd7219be632a3efd78c0149b00c50eef2f3ead7a2876f96751deb07863</citedby><cites>FETCH-LOGICAL-c2333-8ea4c63bd7219be632a3efd78c0149b00c50eef2f3ead7a2876f96751deb07863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8970142$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6332793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zielinski, Florian</creatorcontrib><creatorcontrib>Robinson, Gerald</creatorcontrib><title>Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism</title><title>International journal of nuclear medicine & biology</title><addtitle>Int J Nucl Med Biol</addtitle><description>Palmitic acid is a major physiological substrate of the myocardium and its role in myocardial metabolism is well understood.
11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart.
A rapid and reliable method for producing [
11C]palmitic acid from [
11C]carbon dioxide by the Grignard synthesis is described. All interfering long chain nonradioactive impurities are removed by the purification procedure. As a result, this [
11C]palmitic acid may be used as a tracer for pure palmitic acid in the measurement of regional myocardial function.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Dogs</subject><subject>Heart - diagnostic imaging</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Myocardium - metabolism</subject><subject>Palmitic Acid</subject><subject>Palmitic Acids - chemical synthesis</subject><subject>Pharmacology. Drug treatments</subject><subject>Tomography, Emission-Computed</subject><issn>0047-0740</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhnVISNNt_0EDOpTSHrbRh9eSL4Wy9AsCPTQ9i7E0yqrIlivZhf331eJljzlJM_O8g_QQ8oazj5zx9p6xRm2Zath73Xzo1uqK3F7aL8jLUv4wJnSza2_ITSulUJ28JfnXcZwPWEKhydNDeDrQaclhPlLO9zRCjxEdnSAOYQ6Wgg2O-pTpgFCWjAOO8ymY8SmkESIdjslCdqFeJ8x-KbVNYXQ1MEOfYijDK3LtIRZ8fT435PfXL4_779uHn99-7D8_bK2QUm41QmNb2TsleNdjKwVI9E5py3jT9YzZHUP0wksEp0Bo1fquVTvusGdKt3JD3q17p5z-LlhmM4RiMUYYMS3FaC52vAqqYLOCNqdSMnoz5TBAPhrOzEmvOXk0J49GN6Zbqxq7O-9f-gHdJXR2W-dvz3MoFqLPMNpQLpjuVP2IqNinFcPq4l_AbIoNOFp0IaOdjUvh-Xf8B4_rmXI</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Zielinski, Florian</creator><creator>Robinson, Gerald</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism</title><author>Zielinski, Florian ; Robinson, Gerald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2333-8ea4c63bd7219be632a3efd78c0149b00c50eef2f3ead7a2876f96751deb07863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Dogs</topic><topic>Heart - diagnostic imaging</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>Myocardium - metabolism</topic><topic>Palmitic Acid</topic><topic>Palmitic Acids - chemical synthesis</topic><topic>Pharmacology. Drug treatments</topic><topic>Tomography, Emission-Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Zielinski, Florian</creatorcontrib><creatorcontrib>Robinson, Gerald</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of nuclear medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zielinski, Florian</au><au>Robinson, Gerald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism</atitle><jtitle>International journal of nuclear medicine & biology</jtitle><addtitle>Int J Nucl Med Biol</addtitle><date>1984</date><risdate>1984</risdate><volume>11</volume><issue>2</issue><spage>121</spage><epage>128</epage><pages>121-128</pages><issn>0047-0740</issn><abstract>Palmitic acid is a major physiological substrate of the myocardium and its role in myocardial metabolism is well understood.
11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart.
A rapid and reliable method for producing [
11C]palmitic acid from [
11C]carbon dioxide by the Grignard synthesis is described. All interfering long chain nonradioactive impurities are removed by the purification procedure. As a result, this [
11C]palmitic acid may be used as a tracer for pure palmitic acid in the measurement of regional myocardial function.</abstract><cop>Tarrytown, NY</cop><pub>Elsevier Inc</pub><pmid>6332793</pmid><doi>10.1016/0047-0740(84)90047-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of nuclear medicine & biology, 1984, Vol.11 (2), p.121-128 |
| issn | 0047-0740 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Carbon Radioisotopes Contrast media. Radiopharmaceuticals Dogs Heart - diagnostic imaging Indicators and Reagents Medical sciences Myocardium - metabolism Palmitic Acid Palmitic Acids - chemical synthesis Pharmacology. Drug treatments Tomography, Emission-Computed |
| title | Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism |
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