Dissolution Rate of Cholesterol in Monooctanoin

Dissolution Rate of Cholesterol in Monooctanoin

Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubilit...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 1984-09, Vol.4 (S2), p.166S-168S
1. Verfasser: Bogardus, Joseph B.
Format: Artikel
Sprache:eng
Schlagworte:
Caprylates
Cholelithiasis - drug therapy
Cholesterol
Glycerides - pharmacology
Solubility
Viscosity
Water
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description Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubility measurements. Dissolution rate increased approximately 50% in the presence of 10 to 15% water in monooctanoin. Further studies on viscosity, the effect of polymers and temperature showed that the solvent viscosity had a dominating influence on dissolution rate. This was thought to be caused by the interaction of cholesterol with the solvent in the dissolving surface layer which caused a decrease in the diffusion coefficient (and dissolution rate) of cholesterol. Reducing viscosity and increasing temperature were identified as possible approaches for increasing cholesterol gallstone dissolution rate in monooctanoin.
doi_str_mv 10.1002/hep.1840040831
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subjects Caprylates
Cholelithiasis - drug therapy
Cholesterol
Glycerides - pharmacology
Solubility
Viscosity
Water
title Dissolution Rate of Cholesterol in Monooctanoin
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