The influence of age and multimorbidity on the pharmacokinetics and metabolism of spironolactone

The pharmacokinetics of the metabolites of spironolactone (canrenone and fluorigenic metabolites) were investigated in 10 geriatric female patients with multimorbidity after a multiple daily oral administration of 100 mg spironolactone under steady state conditions. The concentration determinations...

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Veröffentlicht in:	Archives of gerontology and geriatrics 1984-07, Vol.3 (2), p.147-159
Hauptverfasser:	Platt, D., Abshagen, U., Mühlberg, W., Horn, H.-J., Schmitt-Rüth, R., Vollmar, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Blood Proteins - metabolism Canrenone - blood Canrenone - metabolism Chromatography, High Pressure Liquid Disease Erythrocyte Count Female Fluorometry Humans Kinetics Middle Aged multimorbidity pharmacokinetics Pregnadienes - metabolism Protein Binding spironolactone Spironolactone - blood Spironolactone - metabolism Time Factors
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