VIP inhibits histamine-induced ultrastructural changes related to acid secretion by parietal cells
We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric muc...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1984-03, Vol.5 (2), p.277-283 |
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| creator | Anteunis, A. Gespach, C. Astesano, A. Emami, S. Robineaux, R. Rosselin, G. |
| description | We have studied the
in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation
in vivo or
in vitro on gastric mucosa preparations. In contrast, VIP incubation did not produce the ultrastructural changes related to gastric acid secretion, in resting parietal cells. Pretreatment of the glands by VIP resulted in a remarkable suppression of the histamine effect, since the parietal cells assumed an almost resting state. The data (1) indicate that the parietal cells in isolated gastric glands of the guinea pig retain
in vitro the capacity to undergo the ultrastructural changes that are related to acid secretion
in vivo after histamine or cAMP and (2) suggest that VIP is an inhibitor of histamine-induced gastric acid secretion in the guinea pig. It is proposed that VIP could act directly on the parietal cell
via cAMP-phosphodiesterase activation, or indirectly
via gastric somatostatin and/or prostaglandin secretions, inhibiting the H
2 receptor-cAMP system of the parietal cell. |
| doi_str_mv | 10.1016/0196-9781(84)90219-5 |
| format | Article |
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in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation
in vivo or
in vitro on gastric mucosa preparations. In contrast, VIP incubation did not produce the ultrastructural changes related to gastric acid secretion, in resting parietal cells. Pretreatment of the glands by VIP resulted in a remarkable suppression of the histamine effect, since the parietal cells assumed an almost resting state. The data (1) indicate that the parietal cells in isolated gastric glands of the guinea pig retain
in vitro the capacity to undergo the ultrastructural changes that are related to acid secretion
in vivo after histamine or cAMP and (2) suggest that VIP is an inhibitor of histamine-induced gastric acid secretion in the guinea pig. It is proposed that VIP could act directly on the parietal cell
via cAMP-phosphodiesterase activation, or indirectly
via gastric somatostatin and/or prostaglandin secretions, inhibiting the H
2 receptor-cAMP system of the parietal cell.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(84)90219-5</identifier><identifier>PMID: 6089130</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cyclic AMP - metabolism ; Gastric Acid - metabolism ; Guinea pig ; Guinea Pigs ; Histamie H 2 receptor ; Histamine - pharmacology ; Histamine Antagonists ; Isolated gastric glands ; Male ; Microscopy, Electron ; Parietal cells ; Parietal Cells, Gastric - drug effects ; Parietal Cells, Gastric - metabolism ; Parietal Cells, Gastric - ultrastructure ; Ultrastructure ; Vasoactive intestinal peptide ; Vasoactive Intestinal Peptide - pharmacology</subject><ispartof>Peptides (New York, N.Y. : 1980), 1984-03, Vol.5 (2), p.277-283</ispartof><rights>1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-126bebdd68202f04e04b491afce4c642784ca6dccdc7ce2ac52b5f89fab645273</citedby><cites>FETCH-LOGICAL-c357t-126bebdd68202f04e04b491afce4c642784ca6dccdc7ce2ac52b5f89fab645273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(84)90219-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6089130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anteunis, A.</creatorcontrib><creatorcontrib>Gespach, C.</creatorcontrib><creatorcontrib>Astesano, A.</creatorcontrib><creatorcontrib>Emami, S.</creatorcontrib><creatorcontrib>Robineaux, R.</creatorcontrib><creatorcontrib>Rosselin, G.</creatorcontrib><title>VIP inhibits histamine-induced ultrastructural changes related to acid secretion by parietal cells</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>We have studied the
in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation
in vivo or
in vitro on gastric mucosa preparations. In contrast, VIP incubation did not produce the ultrastructural changes related to gastric acid secretion, in resting parietal cells. Pretreatment of the glands by VIP resulted in a remarkable suppression of the histamine effect, since the parietal cells assumed an almost resting state. The data (1) indicate that the parietal cells in isolated gastric glands of the guinea pig retain
in vitro the capacity to undergo the ultrastructural changes that are related to acid secretion
in vivo after histamine or cAMP and (2) suggest that VIP is an inhibitor of histamine-induced gastric acid secretion in the guinea pig. It is proposed that VIP could act directly on the parietal cell
via cAMP-phosphodiesterase activation, or indirectly
via gastric somatostatin and/or prostaglandin secretions, inhibiting the H
2 receptor-cAMP system of the parietal cell.</description><subject>Animals</subject><subject>Cyclic AMP - metabolism</subject><subject>Gastric Acid - metabolism</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Histamie H 2 receptor</subject><subject>Histamine - pharmacology</subject><subject>Histamine Antagonists</subject><subject>Isolated gastric glands</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Parietal cells</subject><subject>Parietal Cells, Gastric - drug effects</subject><subject>Parietal Cells, Gastric - metabolism</subject><subject>Parietal Cells, Gastric - ultrastructure</subject><subject>Ultrastructure</subject><subject>Vasoactive intestinal peptide</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSDdJ_0ELOpXk4FSSZVm6FMKSLwgkhzZXIY3GXRWvvZXkQP597e6SY05zeD9m5iHkC2eXnHH1nXGjKtNqfq7lhWGCm6r5QFZct3XVcGU-ktWb5RM5yfkPY0xKo4_JsWLa8JqtiH--f6Jx2EQfS6abmIvbxgGrOIQJMNCpL8nlkiYoU3I9hY0bfmOmCXtXZr2M1EEMNCMkLHEcqH-lO5cilsWNfZ_PyFHn-oyfD_OU_Lq5_rm-qx4eb-_XVw8V1E1bKi6URx-C0oKJjklk0kvDXQcoQUnRaglOBYAALaBw0AjfdNp0zivZiLY-Jd_2vbs0_p0wF7uNebnADThO2Wou6po1ZjbKvRHSmHPCzu5S3Lr0ajmzC1q7cLMLN6ul_Y_WNnPs66F_8lsMb6EDy1n_sddxfvIlYrIZIg4zxZgQig1jfH_BPxWainc</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Anteunis, A.</creator><creator>Gespach, C.</creator><creator>Astesano, A.</creator><creator>Emami, S.</creator><creator>Robineaux, R.</creator><creator>Rosselin, G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198403</creationdate><title>VIP inhibits histamine-induced ultrastructural changes related to acid secretion by parietal cells</title><author>Anteunis, A. ; Gespach, C. ; Astesano, A. ; Emami, S. ; Robineaux, R. ; Rosselin, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-126bebdd68202f04e04b491afce4c642784ca6dccdc7ce2ac52b5f89fab645273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Cyclic AMP - metabolism</topic><topic>Gastric Acid - metabolism</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Histamie H 2 receptor</topic><topic>Histamine - pharmacology</topic><topic>Histamine Antagonists</topic><topic>Isolated gastric glands</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Parietal cells</topic><topic>Parietal Cells, Gastric - drug effects</topic><topic>Parietal Cells, Gastric - metabolism</topic><topic>Parietal Cells, Gastric - ultrastructure</topic><topic>Ultrastructure</topic><topic>Vasoactive intestinal peptide</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anteunis, A.</creatorcontrib><creatorcontrib>Gespach, C.</creatorcontrib><creatorcontrib>Astesano, A.</creatorcontrib><creatorcontrib>Emami, S.</creatorcontrib><creatorcontrib>Robineaux, R.</creatorcontrib><creatorcontrib>Rosselin, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anteunis, A.</au><au>Gespach, C.</au><au>Astesano, A.</au><au>Emami, S.</au><au>Robineaux, R.</au><au>Rosselin, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VIP inhibits histamine-induced ultrastructural changes related to acid secretion by parietal cells</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1984-03</date><risdate>1984</risdate><volume>5</volume><issue>2</issue><spage>277</spage><epage>283</epage><pages>277-283</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>We have studied the
in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation
in vivo or
in vitro on gastric mucosa preparations. In contrast, VIP incubation did not produce the ultrastructural changes related to gastric acid secretion, in resting parietal cells. Pretreatment of the glands by VIP resulted in a remarkable suppression of the histamine effect, since the parietal cells assumed an almost resting state. The data (1) indicate that the parietal cells in isolated gastric glands of the guinea pig retain
in vitro the capacity to undergo the ultrastructural changes that are related to acid secretion
in vivo after histamine or cAMP and (2) suggest that VIP is an inhibitor of histamine-induced gastric acid secretion in the guinea pig. It is proposed that VIP could act directly on the parietal cell
via cAMP-phosphodiesterase activation, or indirectly
via gastric somatostatin and/or prostaglandin secretions, inhibiting the H
2 receptor-cAMP system of the parietal cell.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6089130</pmid><doi>10.1016/0196-9781(84)90219-5</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1984-03, Vol.5 (2), p.277-283 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cyclic AMP - metabolism Gastric Acid - metabolism Guinea pig Guinea Pigs Histamie H 2 receptor Histamine - pharmacology Histamine Antagonists Isolated gastric glands Male Microscopy, Electron Parietal cells Parietal Cells, Gastric - drug effects Parietal Cells, Gastric - metabolism Parietal Cells, Gastric - ultrastructure Ultrastructure Vasoactive intestinal peptide Vasoactive Intestinal Peptide - pharmacology |
| title | VIP inhibits histamine-induced ultrastructural changes related to acid secretion by parietal cells |
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