Immunological status of mice with long-standing allogeneic or xenogeneic neonatal heart grafts
Adult mice were thymectomized and given 1 X 10(8) allogeneic or xenogeneic spleen cells i.v. On the day following cell injection, the mice were treated with 200 mg/kg cyclophosphamide (Cy) i.p. Of the CBA mice treated according to this protocol, 87% accepted heterotopically transplanted C57BL/6 neon...
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| Veröffentlicht in: | Transplantation 1984-09, Vol.38 (3), p.267-272 |
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| container_title | Transplantation |
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| creator | CHERNYAKHOVSKAYA, I. YU PRIGOZHINA, T. B NAGURSKAYA, E. V FONTALIN, L. N |
| description | Adult mice were thymectomized and given 1 X 10(8) allogeneic or xenogeneic spleen cells i.v. On the day following cell injection, the mice were treated with 200 mg/kg cyclophosphamide (Cy) i.p. Of the CBA mice treated according to this protocol, 87% accepted heterotopically transplanted C57BL/6 neonatal heart grafts and 61% accepted August rat heart grafts. Electrical activity of the grafts could be recorded in the majority of recipients for more than 5 months. Graft acceptance in most cases was specific. Some recipients with long standing rat heart grafts produced antirat hemagglutinins, but were negative for lymphocytotoxins. The absence of xenoantibodies correlated with specific unresponsiveness in the mixed lymphocyte culture (MLC) response. |
| doi_str_mv | 10.1097/00007890-198409000-00014 |
| format | Article |
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YU ; PRIGOZHINA, T. B ; NAGURSKAYA, E. V ; FONTALIN, L. N</creator><creatorcontrib>CHERNYAKHOVSKAYA, I. YU ; PRIGOZHINA, T. B ; NAGURSKAYA, E. V ; FONTALIN, L. N</creatorcontrib><description>Adult mice were thymectomized and given 1 X 10(8) allogeneic or xenogeneic spleen cells i.v. On the day following cell injection, the mice were treated with 200 mg/kg cyclophosphamide (Cy) i.p. Of the CBA mice treated according to this protocol, 87% accepted heterotopically transplanted C57BL/6 neonatal heart grafts and 61% accepted August rat heart grafts. Electrical activity of the grafts could be recorded in the majority of recipients for more than 5 months. Graft acceptance in most cases was specific. Some recipients with long standing rat heart grafts produced antirat hemagglutinins, but were negative for lymphocytotoxins. The absence of xenoantibodies correlated with specific unresponsiveness in the mixed lymphocyte culture (MLC) response.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-198409000-00014</identifier><identifier>PMID: 6382715</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Animals, Newborn - immunology ; Biological and medical sciences ; Graft Survival ; Heart Transplantation ; Immune Tolerance ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Rats ; Rats, Inbred Strains ; Spleen - cytology ; Spleen - transplantation ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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The absence of xenoantibodies correlated with specific unresponsiveness in the mixed lymphocyte culture (MLC) response.</description><subject>Animals</subject><subject>Animals, Newborn - immunology</subject><subject>Biological and medical sciences</subject><subject>Graft Survival</subject><subject>Heart Transplantation</subject><subject>Immune Tolerance</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spleen - cytology</subject><subject>Spleen - transplantation</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Thymectomy</subject><subject>Time Factors</subject><subject>Transplantation, Heterologous</subject><subject>Transplantation, Homologous</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LxDAQhoMo67r6E4QcxFs1X03Soyx-LCx40ashTdNupU3XJEX990a3u1cDkzC8z0yGeQGAGN1gVIhblI6QBcpwIRkqUpalwOwIzHFOWcaRRMdgjhDDGaZUnIKzEN4TklMhZmDGqSQC53Pwtur70Q3d0LRGdzBEHccAhxr2rbHws40b2A2uyZLgqtY1UHeJtc62Bg4eflm3z5wdnI6px8ZqH2HjdR3DOTipdRfsxfQuwOvD_cvyKVs_P66Wd-vMMIJiVhqkC1NIVHJmqNVGkCrnnOsSGyIRZZXAWqeLlLUxhPKSYMoIsRVDNK8lXYDrXd-tHz5GG6Lq22Bs1-k01hiUxISSIsH_gZhRQSnjCZQ70PghBG9rtfVtr_23wkj9eqD2HqiDB-rPg1R6Of0xlr2tDoXT0pN-Nek6pKXXXjvThgMmZZ4zLOkPxuyPMQ</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>CHERNYAKHOVSKAYA, I. YU</creator><creator>PRIGOZHINA, T. 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Graft diseases</topic><topic>Surgery of the heart</topic><topic>Thymectomy</topic><topic>Time Factors</topic><topic>Transplantation, Heterologous</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHERNYAKHOVSKAYA, I. YU</creatorcontrib><creatorcontrib>PRIGOZHINA, T. B</creatorcontrib><creatorcontrib>NAGURSKAYA, E. V</creatorcontrib><creatorcontrib>FONTALIN, L. 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N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological status of mice with long-standing allogeneic or xenogeneic neonatal heart grafts</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1984-09</date><risdate>1984</risdate><volume>38</volume><issue>3</issue><spage>267</spage><epage>272</epage><pages>267-272</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Adult mice were thymectomized and given 1 X 10(8) allogeneic or xenogeneic spleen cells i.v. On the day following cell injection, the mice were treated with 200 mg/kg cyclophosphamide (Cy) i.p. Of the CBA mice treated according to this protocol, 87% accepted heterotopically transplanted C57BL/6 neonatal heart grafts and 61% accepted August rat heart grafts. Electrical activity of the grafts could be recorded in the majority of recipients for more than 5 months. Graft acceptance in most cases was specific. Some recipients with long standing rat heart grafts produced antirat hemagglutinins, but were negative for lymphocytotoxins. The absence of xenoantibodies correlated with specific unresponsiveness in the mixed lymphocyte culture (MLC) response.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>6382715</pmid><doi>10.1097/00007890-198409000-00014</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1984-09, Vol.38 (3), p.267-272 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Animals, Newborn - immunology Biological and medical sciences Graft Survival Heart Transplantation Immune Tolerance Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Rats Rats, Inbred Strains Spleen - cytology Spleen - transplantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Thymectomy Time Factors Transplantation, Heterologous Transplantation, Homologous |
| title | Immunological status of mice with long-standing allogeneic or xenogeneic neonatal heart grafts |
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